New Frontiers in Skeletal Research: Bone, Fat and Brain Connections

骨骼研究的新前沿：骨骼、脂肪和大脑的联系

• 批准号: 7674331
• 负责人: CLIFFORD JAMES ROSEN
• 金额: $ 3.5万
• 依托单位: AMERICAN SOCIETY FOR BONE & MINERAL RES
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-04-06 至 2010-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7674331
• 关键词: Adipocytes; Adipose tissue; American; Anorexia Nervosa; Area; Biological Neural Networks; Body Weight; Brain; Cell Nucleus; Clinical Research; Collaborations; Complex; Cushing Syndrome; Diabetes Mellitus; Discipline; Disease; Endocrinology; Energy Metabolism; Fatty acid glycerol esters; Future; Goals; HIV; Hematology; Hormones; Human; Hypothalamic structure; Insulin; Investigation; Knowledge; Lead; Link; Metabolic; Metabolic syndrome; Metabolism; Minerals; Molecular; Molecular and Cellular Biology; Mus; Neuraxis; Neurology; Neuropeptides; Obesity; Pathway interactions; Physiology; Production; Radiology Specialty; Reproduction; Research; Research Personnel; Role; Schizophrenia; Science; Seminal; Signal Transduction; Skeleton; Societies; Therapeutic Agents; Time; Translating; United States National Institutes of Health; bone; bone mass; bone metabolism; cytokine; frontier; genetic epidemiology; islet; meetings; neurophysiology; novel; novel therapeutics; posters; programs; repository; skeletal; symposium; tool

DESCRIPTION (provided by applicant): The last decade has seen a plethora of investigations delineating the role of the central nervous system in regulating metabolism, reproduction and skeletal turnover. Seminal discoveries in mice but often-confirmed in humans have defined the interactions that link metabolism of adipose tissue with skeletal remodeling through neural networks emanating from nuclei in the hypothalamus. Diseases such as Cushing's syndrome and anorexia nervosa, as well as prevalent disorders such as type 1 or 2 diabetes, obesity and more generally the metabolic syndrome, have illustrated the intimate relationship between the control of body weight and of bone mass. Adverse metabolic effects of commonly used therapeutic agents for treating a wide spectrum of diseases from HIV to schizophrenia reinforce the importance of understanding how body weight and bone mass are regulated through neural networks. Most recently, the delineation of a discrete signal from bone to islet and fat cells, modulating both insulin production and sensitivity, provides compelling evidence of an intimate and critical relationship, whose molecular details are only beginning to emerge, between bone and energy metabolisms. This emerging aspect of endocrinology spans a wide spectrum of disciplines including metabolism, bone physiology, and neurology, and it requires tools of cellular and molecular biology, genetics, epidemiology, radiology, hematology, and neurophysiology to be fully explored. As such, it is appropriate to convene a meeting in which these advances can be considered within the context of both formal talks by leading experts from various disciplines and informal discussions in the format of questions and answers as well as poster presentations. Since this scientific field has evolved quickly and dramatically, the importance of drawing young investigators to a multi-disciplinary meeting and providing them with opportunities for further investigations will be emphasized. The proposed meeting will also serve as an important step towards translating new knowledge into new therapeutic concepts. In addition, this meeting will identify key questions for future research. The American Society for Bone and Mineral Research is the premier society for the study and advancement of basic and clinical research in disorders relating to the skeleton. The considerations described above make it abundantly clear that now is a perfect time for the Society to propose this meeting. Our long-term goal is to advance the science by developing a forum for establishing the necessary collaborations across disciplines. It should also provide NIH with novel ideas about programs worthy of support in future years and lead to a vibrant exchange of ideas and a definition of vital pathways for future advances in research and treatment.

描述（由申请人提供）：在过去的十年中，有大量的研究描述了中枢神经系统在调节代谢、生殖和骨骼周转中的作用。在小鼠中的发现，但经常在人类中得到证实，已经定义了脂肪组织代谢与骨骼重塑之间的相互作用，这种相互作用是通过下丘脑核团发出的神经网络实现的。诸如库欣综合征和神经性厌食症的疾病，以及诸如1型或2型糖尿病、肥胖症和更普遍的代谢综合征的流行疾病，已经说明了体重控制和骨量控制之间的密切关系。用于治疗从HIV到精神分裂症的广泛疾病的常用治疗药物的不良代谢作用加强了了解体重和骨量如何通过神经网络调节的重要性。最近，从骨骼到胰岛和脂肪细胞的离散信号的描绘，调节胰岛素的产生和敏感性，提供了令人信服的证据，证明骨骼和能量代谢之间存在密切和关键的关系，其分子细节才刚刚开始出现。内分泌学的这一新兴方面跨越了包括代谢、骨生理学和神经学在内的广泛学科，并且它需要细胞和分子生物学、遗传学、流行病学、放射学、血液学和神经生理学的工具来充分探索。因此，应当召开一次会议，在各学科主要专家的正式会谈和问答形式的非正式讨论以及海报展示的范围内审议这些进展。由于这一科学领域的发展迅速，戏剧性的，吸引年轻的研究人员参加多学科会议，并为他们提供进一步调查的机会的重要性将得到强调。拟议的会议也将成为将新知识转化为新的治疗概念的重要一步。此外，本次会议将确定未来研究的关键问题。美国骨与矿物质研究学会是研究和促进骨骼相关疾病基础和临床研究的首要学会。上述考虑充分表明，现在是协会提议举行这次会议的最佳时机。我们的长期目标是通过开发一个论坛来建立跨学科的必要合作，从而推动科学发展。它还应该为NIH提供有关未来几年值得支持的项目的新想法，并导致充满活力的思想交流和对未来研究和治疗进展的重要途径的定义。