Clinical System for Measurement of Oral Crest Height Change in Dental Radiographs

牙科射线照片中口腔嵴高度变化测量的临床系统

• 批准号: 7745541
• 负责人: Alan Michael Walczak
• 金额: $ 9.97万
• 依托单位: IMAGINATION SOFTWARE CORPORATION
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-09-01 至 2011-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7745541
• 关键词: Address; Algorithms; Automation; Bone Diseases; Caring; Clinical; Computer Assisted; Computer software; Coupled; Data; Dental; Dental Care; Dental Enamel; Dental General Practice; Dental Offices; Dentists; Development; Diagnosis; Disease; Electronics; Ensure; Eye; General Practitioners; Goals; Healthcare; Height; Image; Image Analysis; Jaw; Literature; Location; Manuals; Marketing; Measurement; Measures; Methodology; Methods; Monitor; Oral; Oral cavity; Oral health; Patient Care; Patients; Penetration; Periodontal Diseases; Phase; Reproducibility; Research; Site; Speed; Staging; Structure; Sum; System; Techniques; Technology; Time; Tooth Loss; Tooth structure; Translations; Visit; Work; alveolar bone; base; bone; bone health; graphical user interface; image processing; image registration; improved; innovation; interest; meetings; public health relevance; tool; user-friendly

DESCRIPTION (provided by applicant): Alveolar bone height correlates well with subsequent tooth loss. In research settings, manual measurements of bone height from digitized images of radiographs have shown a precision of about 0.5 mm which can be improved further by using image processing and registration techniques. Based on these data, we believe that bone height change can be measured reliably from dental radiographs and that dental care would improve if these measurements were brought into the dental office. But translation of these techniques will require a "system" which is well-suited to the normal work flow of the dental office. The goal of this proposal is the development and implementation of a reliable, sensitive, easy to use, rapid system for measurement of alveolar bone height change which will be accepted and desired in the general practitioner's office. Simply stated, our goal is to develop the system that general practitioners will want and that they will view as an essential part of their patient care capabilities. To achieve this goal, we are proposing innovative approaches to address issues which have obstructed translation of crest height measurements in oral radiographs into general dental practice. (1) For single radiographs, we will use manual indication of the cemento-enamel junction (CEJ) and crest-tooth junction, but we will use image analysis to refine and improve the accuracy of these indications, thereby also removing the onus of careful placement of points. (2) When two or more radiographs are compared for assessment of bone height change, (a) we will automatically register the CEJ and crest-tooth junctions in the radiographs to further improve the accuracy of the change measurements and (b) we will automatically determine and correct for jaw angulation. (3) We will package these techniques in a simple, easy to use, and quick graphical user interface. Our ultimate goal (after completion of Phase 2) is to perform automated full-mouth (64 sites) analysis based on the methodology developed in Phase 1 (for a single site) in less than one minute per patient. All past methods for measuring bone height are not simple, accurate, and rapid enough for use in the dental office; our proposed product meets these criteria. This complete system, prototyped in Phase 1 and completed in Phase 2, will provide the general practitioner with the means to assess bone height change for every patient, for each site, in an easy and rapid manner. As a result, diagnosis of destructive periodontal disease will be available without negative effects on normal clinical work flow or patient comfort. This system will result in a new first line of defense in the diagnosis and treatment of destructive periodontal disease, giving the general practitioner the ability to detect and treat the disease at an earlier stage. Thus, we expect our system to be adapted easily into dental practice and achieve strong market penetration, which (coupled with accurate, precise, and reliable data) means improved dental care for millions of patients. PUBLIC HEALTH RELEVANCE: Alveolar bone height correlates well with subsequent tooth loss. The goal of this proposal is the development and implementation of a reliable, sensitive, easy to use, rapid system for measurement of alveolar bone height change for the general practitioner's office. This system will consist of methods for measurement of crest height in single images, measurement of crest height change in two or more images, and a simple, easy to use, software interface. This complete system will provide the general practitioner with the means to assess bone height change for every patient, for each site, in a rapid manner. This system will result in a new first line of defense in the diagnosis of periodontal disease and its activity that has the ability to monitor all patients who visit the dental office, thus giving the general practitioner the ability to detect and treat the disease at an earlier stage.

描述（由申请人提供）：牙槽骨高度与随后的牙齿脱落密切相关。在研究环境中，从射线照片的数字化图像手动测量骨高度已经显示出约0.5mm的精度，其可以通过使用图像处理和配准技术进一步提高。基于这些数据，我们相信，骨高度的变化可以可靠地测量从牙科X光片，牙齿护理会改善，如果这些测量被带到牙科诊所。但是，这些技术的翻译将需要一个“系统”，这是非常适合牙科诊所的正常工作流程。本提案的目标是开发和实施一种可靠、灵敏、易于使用、快速的牙槽骨高度变化测量系统，该系统将被全科医生办公室接受和期望。简单地说，我们的目标是开发全科医生想要的系统，他们将视之为他们的病人护理能力的重要组成部分。为了实现这一目标，我们提出了创新的方法，以解决问题，阻碍翻译的波峰高度测量口腔X光片到一般的牙科实践。(1)对于单次X线片，我们将使用牙骨质-釉质结合部（CEJ）和牙顶-牙齿结合部的手动指示，但我们将使用图像分析来细化和提高这些指示的准确性，从而也消除了仔细放置点的责任。(2)当比较两张或多张X线片以评估骨高度变化时，（a）我们将自动配准X线片中的CEJ和牙顶-牙齿连接处，以进一步提高变化测量的准确性，（B）我们将自动确定并校正颌骨成角。(3)我们将把这些技术打包到一个简单、易用、快速的图形用户界面中。我们的最终目标（第2阶段完成后）是根据第1阶段开发的方法（针对单个部位），在每位患者不到一分钟的时间内进行全口（64个部位）自动分析。所有过去用于测量骨高度的方法对于牙科诊所来说都不够简单、准确和快速;我们提出的产品符合这些标准。这个完整的系统，原型在第1阶段，并在第2阶段完成，将提供全科医生的手段，以评估骨高度的变化，为每一个病人，为每个网站，在一个简单和快速的方式。因此，破坏性牙周病的诊断将是可用的，而不会对正常的临床工作流程或患者的舒适度产生负面影响。该系统将在破坏性牙周病的诊断和治疗中形成新的第一道防线，使全科医生能够在早期阶段检测和治疗疾病。因此，我们希望我们的系统能够很容易地适应牙科实践，并实现强大的市场渗透，这（加上准确，精确和可靠的数据）意味着改善数百万患者的牙科护理。 公共卫生相关性：牙槽骨高度与随后的牙齿脱落密切相关。本提案的目标是为全科医生办公室开发和实施一种可靠、灵敏、易于使用、快速测量牙槽骨高度变化的系统。该系统将包括在单个图像中测量波峰高度的方法、在两个或更多个图像中测量波峰高度变化的方法以及简单易用的软件界面。这个完整的系统将为全科医生提供快速评估每个患者每个部位骨高度变化的方法。该系统将成为牙周病诊断及其活动的新的第一道防线，能够监测所有访问牙科诊所的患者，从而使全科医生能够在早期阶段检测和治疗疾病。