Visual/Spatial Properties of Posterior Parietal Neurons

后顶叶神经元的视觉/空间特性

• 批准号: 7811905
• 负责人: RICHARD A ANDERSEN
• 金额: $ 75.14万
• 依托单位: CALIFORNIA INSTITUTE OF TECHNOLOGY
• 依托单位国家: 美国
• 财政年份: 1994
• 资助国家: 美国
• 起止时间: 1994-03-01 至 2012-09-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7811905
• 关键词: Area; Attention; Behavior; Behavioral; Brain; Cognitive; Contralateral; Coupled; Cues; Data; Data Analyses; Decision Making; Diagnosis; Disease; Employee; Engineering; Equipment; Evaluation; Event; Exhibits; Eye; Functional Imaging; Functional Magnetic Resonance Imaging; Funding; Goals; Grant; Hand; Human; Individual; Joystick; Knowledge; Left; Lip structure; Location; Magnetic Resonance Imaging; Methodology; Methods; Modeling; Monkeys; Motor; Motor output; Movement; Neurons; Parietal; Parietal Lobe; Patients; Population; Positioning Attribute; Postdoctoral Fellow; Primates; Process; Property; Public Health; Recovery; Research; Rewards; Role; Saccades; Schedule; Sensory; Signal Transduction; Staging; Stroke; Techniques; Testing; Time; Traumatic Brain Injury; United States National Institutes of Health; Upper arm; Variant; Visual; Visual Cortex; Visuospatial; base; eye hand coordination; flexibility; insight; memory encoding; nervous system disorder; neuromechanism; neurophysiology; new technology; nonhuman primate; novel; parent grant; preference; prospective; public health relevance; relating to nervous system; research study; response; segregation; therapy design; virtual; visual motor

DESCRIPTION (provided by applicant): This Competitive Revision is submitted in response to the notice NOT-OD-09-058: NIH Announces the Availability of Recovery Act Funds for Competitive Revision Applications. This application expands the scope and the methodology of the parent grant "Visual/Spatial Properties of Posterior Parietal Neurons" to include two additional research aims. Most of the current knowledge about neural mechanisms underlying eye-hand coordination and selection of movement plans has been derived from electrophysiological recordings in non-human primates, and more recently from fMRI experiments in humans. In order to be able to integrate those findings, it is necessary to study both species by means of the same method, especially because results from the two techniques have not always led to the same conclusions. The current grant revision aims to elucidate the discrepancy between monkey and human studies concerning the degree of overlap between hand and eye signals within the frontoparietal network. Specifically, we will investigate how spatial and effector choices are represented in the monkey brain by applying event-related fMRI while monkeys are choosing either between spatial target positions (i.e. left vs. right) or between different effectors (i.e. eye vs. hand). In addition, we will expand ongoing neurophysiological experiments by investigating how spatial choice preferences originating either from internal or external factors are represented by different areas in the brain. This revision adheres to the goals of the Recovery Act. It will entail retaining a current senior postdoc employee, hiring a new postdoc, a new technician, and a new part-time RF engineer. It will invest in the new technology essential to expand the goals of the project, by acquiring advanced MR-compatible equipment from domestic companies. PUBLIC HEALTH RELEVANCE: The results of the proposed studies can be used to help design therapies for patients suffering from damage to frontal and parietal cortex from strokes and traumatic brain injuries. Application of functional imaging in monkeys, as routinely is done in human patients and healthy subjects, will facilitate the understanding of normal cortical functions and deficits that result from neurological diseases, and can guide the diagnoses and treatments for these diseases

描述（由申请人提供）：本竞争性修订版是为了响应通知NOT-OD-09-058：NIH宣布恢复法案资金可用于竞争性修订申请而提交的。此应用程序扩展的范围和方法的母基金“后顶叶神经元的视觉/空间特性”，包括两个额外的研究目标。目前关于眼手协调和运动计划选择的神经机制的知识大多来自非人类灵长类动物的电生理记录，最近来自人类的fMRI实验。为了能够整合这些发现，有必要通过相同的方法研究这两个物种，特别是因为这两种技术的结果并不总是得出相同的结论。目前的拨款修订旨在阐明猴子和人类研究之间的差异，这些研究涉及额顶叶网络中手和眼信号之间的重叠程度。具体来说，我们将研究如何空间和效应器的选择是通过应用事件相关的功能磁共振成像在猴子的大脑中表示，而猴子选择空间目标位置之间（即左与右）或不同的效应器之间（即眼睛与手）。此外，我们将扩大正在进行的神经生理学实验，研究如何空间选择偏好起源于内部或外部因素是由大脑中的不同区域。这一修订符合《复苏法》的目标。这将需要保留目前的高级博士后员工，雇用一名新的博士后，一名新的技术人员和一名新的兼职RF工程师。它将通过从国内公司购买先进的MR兼容设备，投资于扩大项目目标所必需的新技术。 公共卫生相关性：拟议研究的结果可用于帮助设计中风和创伤性脑损伤导致额叶和顶叶皮层受损的患者的治疗方法。功能成像在猴中的应用，正如在人类患者和健康受试者中所做的常规工作一样，将有助于了解正常皮层功能和神经系统疾病引起的缺陷，并可指导这些疾病的诊断和治疗