National Trends in Brain Health: a Follow-Up Study of CIND and Dementia in the US

脑健康的全国趋势：美国 CIND 和痴呆症的后续研究

• 批准号: 7853012
• 负责人: DAVID R. WEIR
• 金额: $ 62.55万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-09-30 至 2011-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7853012
• 关键词: Age; Alzheimer' s Disease; Behavior; Behavioral; Biological; Biological Markers; Blood Pressure; Brain; C-reactive protein; Cessation of life; Child; Cholesterol; Chronic Disease; Clinical assessments; Cognition; Cognitive; Communities; Consensus; Data; Data Set; Decision Making; Dementia; Demographic Aging; Diagnosis; Economics; Elderly; Family; Family health status; Follow-Up Studies; Funding; Future; Genetic; Glycosylated hemoglobin A; Gold; Growth; Health; Health Care Costs; Healthcare Systems; Home environment; Impaired cognition; Individual; Interview; Lead; Learning; Link; Marketing; Measures; Medical; Medical Economics; Medicare; Medicare/Medicaid; Memory; Methodology; Modeling; Outcome; Parents; Performance; Physical Function; Population; Prevalence; Prevalence Study; Public Health; Public Policy; Recording of previous events; Research; Research Infrastructure; Resources; Respondent; Retirement; Risk; Risk Factors; Role; Sampling; Severities; Social Security; Societies; Speed; Spouses; Statistical Models; Surveys; Vascular Dementia; Walking; Work; base; caregiving; clinical Diagnosis; cost; disability; economic outcome; indexing; policy implication; programs; public health relevance; rapid growth; social; trend; waist circumference

DESCRIPTION (provided by applicant): We propose to study US trends in the prevalence of cognitive impairment and dementia by performing a new Aging, Demographics, and Memory Study (ADAMS 2010) that uses a similar methodology to that employed for the original NIA-funded study performed in 2001-2003. This new study will leverage the original ADAMS research team, the established national fieldwork infrastructure of the ADAMS and its parent Health and Retirement Study (HRS), and the lessons learned from the past 8 years of ADAMS work to create a unique publicly-available data resource that can be used by multi-disciplinary research teams to study the prevalence, causes, and consequences of cognitive impairment and dementia, and changes in them over the first decade of the 21st century. The specific aims of the project are to: 1) Conduct in-home clinical assessments of cognition in a sub-sample of 1000 HRS respondents age > 70, and establish a consensus diagnosis of normal, cognitive impairment without dementia (CIND), or dementia; 2) Provide to the research community a data set on the ADAMS 2010 sub-sample that contains information from the in- home assessments which can be linked to all prior and future waves of the HRS, including HRS biomarker data, HRS physical measures, Medicare administrative data, the HRS decedent interview, and the National Death Index; and 3) Use ADAMS 2010 data to derive a statistical model for assessing CIND and dementia for all HRS respondents age > 70, utilizing the cross- walk between the "gold-standard" clinical diagnoses of CIND and dementia in the ADAMS and the core HRS survey measures of cognition and physical function. This model can then be used with future HRS waves to cost-effectively track population cognitive health in the US. The proposed ADAMS 2010, in conjunction with the original ADAMS and the on-going HRS, will provide the first nationally representative data to assess the prevalence and trends of CIND and dementia in the US. Given the wide-ranging impact of CIND and dementia on individuals, families, and society, and the projected large growth in the number of older adults with dementia in the coming decades, the proposed project to create an unprecedented set of nationally-representative data that can support multi-disciplinary research on key questions regarding dementia prevalence, risk factors and outcomes is truly a "Grand Opportunity." PUBLIC HEALTH RELEVANCE: Cognitive impairment and dementia are extremely common among older adults and result in disability that generates significant costs and burdens for families, the health care system, and public programs such as Medicare, Medicaid, and Social Security. The proposed research will collect data that will lead to a better understanding of trends in the prevalence, causes, and outcomes of dementia in the US and will, therefore, have major public health and public policy implications as we now enter the period of the most rapid growth of the elderly population in our history.

描述(由申请人提供)：我们建议通过进行一项新的老龄化、人口统计和记忆研究(ADAMS 2010)来研究美国认知障碍和痴呆症的流行趋势，该研究使用的方法与2001-2003年由NIA资助的原始研究采用的方法类似。这项新的研究将利用最初的ADAMS研究团队、ADAMS及其母公司健康和退休研究(HRS)建立的国家实地工作基础设施，以及从过去8年的亚当斯工作中吸取的教训，创建一个独特的公开可用的数据资源，可供多学科研究团队使用，以研究认知障碍和痴呆症的患病率、原因和后果，以及它们在21世纪第一个十年的变化。该项目的具体目标是：1)在1000名70岁的HRS受访者中进行认知的家庭临床评估，并建立对正常的、非痴呆症(CIND)或痴呆症的认知损害的共识诊断；2)向研究界提供关于ADAMS 2010年子样本的数据集，其中包含来自家庭评估的信息，这些信息可以与HRS之前和未来的所有HRS浪潮相关联，包括HRS生物标记物数据、HRS物理测量、医疗保险管理数据、HRS死者访谈和国家死亡指数；3)使用ADAMS 2010年的数据，利用ADAMS中对CIND和痴呆症的“黄金标准”临床诊断与核心HRS认知和身体功能调查测量之间的交叉，得出一个统计模型，用于评估所有70岁的HRS受访者的CIND和痴呆症。然后，该模型可以与未来的HRS波一起使用，以经济高效的方式跟踪美国人口的认知健康。拟议的ADAMS 2010，连同最初的ADAMS和正在进行的HRS，将提供第一个具有全国代表性的数据，以评估CIND和痴呆症在美国的患病率和趋势。鉴于CIND和痴呆症对个人、家庭和社会的广泛影响，以及预计未来几十年患痴呆症的老年人数量将大幅增长，拟议中的项目创建一组史无前例的具有全国代表性的数据，可以支持关于痴呆症患病率、风险因素和结果的关键问题的多学科研究，这确实是一个“巨大的机遇”。 与公共健康相关：认知障碍和痴呆症在老年人中非常常见，并会导致残疾，这会给家庭、医疗保健系统以及联邦医疗保险、医疗补助和社会保障等公共项目带来巨大的成本和负担。拟议中的研究将收集数据，这些数据将有助于更好地了解美国痴呆症的患病率、原因和后果的趋势，因此，随着我们进入历史上老年人口增长最快的时期，这项研究将对公共卫生和公共政策产生重大影响。