Creating a National Resource for Genetic Research in Behavioral & Health Sciences

描述(由申请人提供)：由于基因分型成本的下降、全基因组关联研究的统计方法的发展以及在一项主要的多学科公共使用的老龄化纵向研究中创建了一个关于16,000名参与者的大量遗传物质储存库，创造了一个重大的科学进步机会。健康和退休研究(HRS)始于1992年，为数据共享和传播设定了标准，1000多名不同的作者和合著者发表了1000多份出版物。它在健康、心理特征、社会网络以及经济状况和行为等领域的丰富测量创造了一个无与伦比的表型数据体系，这些数据现在可以与使用Illumina 1M SNP芯片的丰富的基因特征相匹配。作为许多已建立的GWA研究的复制样本，该资源以行为衰老研究中已广为人知的研究为基础，将彻底改变行为科学的研究，将其作为将遗传学与行为表型相结合的首批大规模研究之一，为发现创造一个平台。 具体地说，该项目的目标是通过遗传病研究中心(CIDR)对大约16,000个来自唾液的样本进行基因分型；通过DBGaP提供有限表型的基因数据；创建一个在研究界更广泛地共享基因和更广泛的表型数据的程序；并与已建立的心血管健康和认知表型进行有限的相关性研究，以展示数据资源的潜力，并作为未来研究的范例。在本项目结束时，数据和数据共享机制将纳入正在进行的人力资源报告。 公共卫生相关性：该项目将对正在进行的美国老年人纵向研究中的16,000名个体参与者进行基因分析，并创建机制，使全国各地合格的研究人员能够访问数据，对老年人的健康和行为进行科学分析。它将对心血管健康和认知方面的遗传因素进行示范研究。

DESCRIPTION (provided by applicant): A Grand Opportunity for scientific advance has been created by the confluence of falling costs of genotyping, the development of statistical methods for genome-wide association studies (GWAS), and the creation of a substantial repository of genetic material on 16,000 participants in a major multi-disciplinary public-use longitudinal study of aging. The Health and Retirement Study (HRS), begun in 1992, sets the standard for data-sharing and dissemination, with over 1,000 publications by over 1,000 different authors and co-authors. Its rich measurement across domains of health, psychological characteristics, social networks, and economic status and behavior creates an unparalleled body of phenotypic data observed over time that can now be paired with a rich genotypic characterization using the Illumina 1m SNP chip. Valuable as a replication sample for many established GWA studies, this resource, building on a study already widely known in behavioral aging research, will revolutionize research on behavioral science as one of the first large-scale studies to combine genetics with behavioral phenotypes, creating a platform for discovery. Specifically, this project aims to conduct genotyping through the Center for Inherited Disease Research (CIDR) on approximately 16,000 samples derived from saliva; to make the genotype data available through dbGap with a limited array of phenotypes; to create a process for sharing genotype and broader phenotype data more widely in the research community; and to conduct a limited set of association studies with established phenotypes of cardiovascular health and cognition to demonstrate the potential of the data resource and serve as examples for future studies. The data and data-sharing mechanisms will be integrated into the ongoing HRS at the conclusion of this project. PUBLIC HEALTH RELEVANCE: This project will conduct genetic analysis on 16,000 individual participants in an ongoing longitudinal study of older Americans, and create mechanisms by which qualified researchers anywhere in the country can access the data for scientific analysis of health and behavior in the older population. It will conduct demonstration studies of genetic factors in cardiovascular health and in cognition.