Health and Retirement Study Yrs 23-28

描述（由申请人提供）：这是一份针对健康与退休研究（HRS）合作协议第23-28年的竞争性延续提案，以响应NIA RFA #AG-12-001。我们建议继续在前两个更新周期中制定的稳态设计上收集核心数据，并在前一个周期中建立的旋转半样本设计上收集生物标志物和物理性能指标。 HRS为研究老龄化的健康、经济和人口统计学的科学和政策研究人员提供了一个独特的、丰富的、具有全国代表性的纵向数据集。它提供了一个研究数据库，可以同时支持美国50岁以上人口的横截面描述，在相当长的一段时间内对给定队列的纵向研究以及对跨队列趋势的研究。HRS项目创建了一个超出核心调查数据的数据系统。这一扩展数据系统的一个组成部分包括与行政数据的链接，包括社会保障收入和福利记录、医疗保险使用和诊断记录、雇主养老金记录和国家死亡指数。我们计划扩大这些联系，包括医疗补助记录，链接到退伍军人管理局的数据，并从最低数据集的养老院居民的信息。另一个组成部分是来自同意的受访者的全基因组基因分型数据，这些数据将在下一个更新周期开始时在dbGaP中提供。 HRS提供公共使用数据，旨在让美国科学界的全部力量和创造力来应对人口老龄化的挑战。HRS正在通过研究者发起的研究对老龄化研究产生重大影响，该研究使用HRS作为研究人员或授权机构的免费投入。1,000多名不同作者和合著者发表的1,000多篇同行评审期刊出版物以及200多篇博士论文都是基于HRS发表的。

DESCRIPTION (provided by applicant): This is a competing continuation proposal for Years 23-28 of the Health and Retirement Study (HRS) cooperative agreement, in response to NIA RFA #AG-12-001. We propose to continue core data collection on the steady-state design laid out in the two previous renewal cycles, and collect biomarkers and measures of physical performance in in-person interviews on the rotating half-sample design established in the previous cycle. HRS provides a uniquely rich, nationally representative longitudinal dataset for the community of scientific and policy researchers who study the health, economics and demography of aging. It provides a research data base that can simultaneously support cross-sectional descriptions of the U.S. population over the age of fifty, longitudinal studies of a given cohort over a substantia period of time and research on cross-cohort trends. The HRS project creates a data system extending beyond the core survey data. One component of this extended data system consists of linkages to administrative data, including Social Security earnings and benefit records, Medicare utilization and diagnostic records, employer pension records, and the National Death Index. We plan to expand these linkages to include Medicaid records, links to Veteran's Administration data, and information on nursing home residents from the Minimum Data Set. Another component is genome-wide genotyping data from consenting respondents that will be available in dbGaP by the start of this next renewal cycle. The HRS provides public use data designed to allow the full power and creativity of America's scientific community to address the challenges of an aging population. The HRS is making a significant impact on research on aging through investigator-initiated research which uses the HRS as an input without charge to researchers or granting agencies. Over 1,000 peer-reviewed journal publications by over 1,000 different authors and co-authors and over 200 doctoral dissertations have appeared based on the HRS.