Expanding a National Resource for Genetic Research in Behavioral & Health Science

扩大行为遗传学研究的国家资源

• 批准号: 8142281
• 负责人: DAVID R. WEIR
• 金额: $ 32.05万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-09-30 至 2013-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8142281
• 关键词: Expanding; National; Resource; Genetic; Research

Abstract This project will utilize high-throughput genetic technologies in a major longitudinal behavioral study and renew the biomedical research community by building scientific partnerships for the integration of behavioral and genetic science. The 7,000 individual participants to be genotyped will be added to a database of 13,000 being constructed under an earlier ARRA project. The Health and Retirement Study (HRS), begun in 1992, sets the standard for data-sharing and dissemination, with over 1,000 publications by over 1,000 different authors and co-authors. Its rich measurement across domains of health, psychological characteristics, social networks, and economic status and behavior creates an unparalleled body of phenotypic data observed over time that can now be paired with a rich genotypic characterization of a million SNPs using the Illumina Omni1-quad beadchip. Valuable as a replication sample for many established GWA studies, this resource, building on a study already widely known in behavioral aging research, will revolutionize research on behavioral science as one of the first large-scale studies to combine genetics with behavioral phenotypes, creating a platform for discovery. Specifically, this project aims to conduct genotyping through the Center for Inherited Disease Research (CIDR) on approximately 7,000 samples derived from saliva; to make the genotype data available through dbGaP with a limited array of phenotypes; to maintain a process for sharing genotype and broader phenotype data more widely in the research community; and to conduct a limited set of association studies with established phenotypes of cardiovascular health and cognition to demonstrate the potential of the data resource and serve as examples for future studies. The data and data-sharing mechanisms will be integrated into the ongoing HRS at the conclusion of this project.

摘要 该项目将利用高通量遗传技术在一个主要的纵向行为 通过建立科学伙伴关系，研究和更新生物医学研究界， 行为科学和遗传科学的结合。将对7,000名个体参与者进行基因分型 将被添加到一个13,000人的数据库中，该数据库是在早期的ARRA项目下建造的。的 健康和退休研究（HRS），始于1992年，为数据共享和 1，000多名不同作者和合著者发表了1，000多篇出版物。其 在健康、心理特征、社交网络和 经济地位和行为创造了一个无与伦比的表型数据体， 时间，现在可以配对与丰富的基因型表征的一百万个SNP使用 Illumina Omni1-quad beadchip。作为许多已建立的GWA的复制样本很有价值 研究，这个资源，建立在一个已经在行为老化研究中广为人知的研究基础上， 将彻底改变行为科学的研究，作为第一个大规模的研究之一， 联合收割机将遗传学与行为表型结合起来，创造一个发现的平台。 具体而言，该项目旨在通过遗传疾病中心进行基因分型 研究（CIDR）对约7,000份唾液样本进行分析， 通过dbGaP获得的表型阵列有限的数据;维护一个过程， 在研究界更广泛地分享基因型和更广泛的表型数据;以及 对已确定的心血管疾病表型进行有限的关联研究， 健康和认知，以展示数据资源的潜力，并作为例子 为将来的研究。数据和数据共享机制将纳入正在进行的 HRS在该项目结束时。

项目成果

Genome-wide association meta-analysis in Chinese and European individuals identifies ten new loci associated with systemic lupus erythematosus.

中国和欧洲个体的全基因组关联荟萃分析确定了与系统性红斑狼疮相关的十个新位点

• DOI: 10.1038/ng.3603
• 发表时间: 2016-08
• 期刊: Nature genetics
• 影响因子: 30.8
• 作者: Morris DL;Sheng Y;Zhang Y;Wang YF;Zhu Z;Tombleson P;Chen L;Cunninghame Graham DS;Bentham J;Roberts AL;Chen R;Zuo X;Wang T;Wen L;Yang C;Liu L;Yang L;Li F;Huang Y;Yin X;Yang S;Rönnblom L;Fürnrohr BG;Voll RE;Schett G;Costedoat-Chalumeau N;Gaffney PM;Lau YL;Zhang X;Yang W;Cui Y;Vyse TJ
• 通讯作者: Vyse TJ

The Bell Curve Revisited: Testing Controversial Hypotheses with Molecular Genetic Data.

• DOI: 10.15195/v3.a23
• 发表时间: 2016-07
• 期刊: Sociological science
• 影响因子: 3.4
• 作者: Conley D;Domingue B
• 通讯作者: Domingue B