National Trends in Brain Health: a Follow-Up Study of CIND and Dementia in the US

描述（由申请人提供）：我们建议通过执行一项新的老龄化，人口统计和记忆研究（ADAMS 2010）来研究美国认知障碍和痴呆流行的趋势，该研究使用与2001-2003年nia资助的原始研究相似的方法。这项新研究将利用原始亚当斯研究团队,建立国家实地亚当斯的基础设施及其母公司对退休人员健康研究(小时),和过去8年的教训亚当斯努力创造一个独特的公共数据资源,可以通过多学科的研究小组研究了流行,原因,和认知障碍和痴呆的后果,改变他们在21世纪的第一个十年。该项目的具体目标是：1)对1000名年龄在100 - 70岁的HRS受访者进行家庭认知临床评估，并建立正常、认知障碍无痴呆（CIND）或痴呆的共识诊断；2)向研究界提供关于ADAMS 2010子样本的数据集，其中包含来自家庭评估的信息，这些信息可以与HRS之前和未来的所有HRS浪潮相关联，包括HRS生物标志物数据、HRS物理测量、医疗保险管理数据、HRS死者访谈和国家死亡指数；3)利用ADAMS 2010数据，利用ADAMS中CIND和痴呆的“金标准”临床诊断与HRS的核心调查指标认知和身体功能之间的交叉行走，推导出评估年龄在bb0 ~ 70岁的所有HRS被调查者CIND和痴呆的统计模型。该模型可用于未来的HRS波，以经济有效地跟踪美国人口的认知健康。拟议的ADAMS 2010，与最初的ADAMS和正在进行的HRS一起，将提供第一个具有全国代表性的数据，以评估美国CIND和痴呆的患病率和趋势。鉴于CIND和痴呆症对个人、家庭和社会的广泛影响，以及预计未来几十年老年痴呆症患者数量的大幅增长，拟议的项目将创建一套前所未有的具有全国代表性的数据，以支持有关痴呆症患病率、风险因素和结果的关键问题的多学科研究，这确实是一个“重大机遇”。

DESCRIPTION (provided by applicant): We propose to study US trends in the prevalence of cognitive impairment and dementia by performing a new Aging, Demographics, and Memory Study (ADAMS 2010) that uses a similar methodology to that employed for the original NIA-funded study performed in 2001-2003. This new study will leverage the original ADAMS research team, the established national fieldwork infrastructure of the ADAMS and its parent Health and Retirement Study (HRS), and the lessons learned from the past 8 years of ADAMS work to create a unique publicly-available data resource that can be used by multi-disciplinary research teams to study the prevalence, causes, and consequences of cognitive impairment and dementia, and changes in them over the first decade of the 21st century. The specific aims of the project are to: 1) Conduct in-home clinical assessments of cognition in a sub-sample of 1000 HRS respondents age > 70, and establish a consensus diagnosis of normal, cognitive impairment without dementia (CIND), or dementia; 2) Provide to the research community a data set on the ADAMS 2010 sub-sample that contains information from the in- home assessments which can be linked to all prior and future waves of the HRS, including HRS biomarker data, HRS physical measures, Medicare administrative data, the HRS decedent interview, and the National Death Index; and 3) Use ADAMS 2010 data to derive a statistical model for assessing CIND and dementia for all HRS respondents age > 70, utilizing the cross- walk between the "gold-standard" clinical diagnoses of CIND and dementia in the ADAMS and the core HRS survey measures of cognition and physical function. This model can then be used with future HRS waves to cost-effectively track population cognitive health in the US. The proposed ADAMS 2010, in conjunction with the original ADAMS and the on-going HRS, will provide the first nationally representative data to assess the prevalence and trends of CIND and dementia in the US. Given the wide-ranging impact of CIND and dementia on individuals, families, and society, and the projected large growth in the number of older adults with dementia in the coming decades, the proposed project to create an unprecedented set of nationally-representative data that can support multi-disciplinary research on key questions regarding dementia prevalence, risk factors and outcomes is truly a "Grand Opportunity." PUBLIC HEALTH RELEVANCE: Cognitive impairment and dementia are extremely common among older adults and result in disability that generates significant costs and burdens for families, the health care system, and public programs such as Medicare, Medicaid, and Social Security. The proposed research will collect data that will lead to a better understanding of trends in the prevalence, causes, and outcomes of dementia in the US and will, therefore, have major public health and public policy implications as we now enter the period of the most rapid growth of the elderly population in our history.