Expanding a National Resource for Genetic Research in Behavioral & Health Science

扩大行为遗传学研究的国家资源

• 批准号: 8047500
• 负责人: DAVID R. WEIR
• 金额: $ 568.31万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-09-30 至 2014-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8047500
• 关键词: African American; Aging; American; Applied Genetics; Award; Behavior; Behavioral; Behavioral Genetics; Behavioral Sciences; Biological Markers; Biomedical Research; Cardiovascular system; Characteristics; Cognition; Cognitive; Collection; Communities; Consent; Country; DNA; Data; Databases; Disease; Economics; Elderly; Enrollment; Family; Future; Genes; Genetic; Genetic Databases; Genetic Research; Genetic Risk; Genome; Genomics; Genotype; Health; Health Sciences; Health behavior; Heart; Hispanic Americans; Hispanics; Individual; Inherited; International; Interview; Life; Link; Longitudinal Studies; Measurement; Mental Health; Methodology; Minority; Monitor; Older Population; Participant; Phenotype; Physical Function; Process; Publications; Qualifying; Recruitment Activity; Research; Research Personnel; Resources; Respondent; Retirement; Risk Factors; Saliva; Sampling; Science; Scientist; Security; Single Nucleotide Polymorphism; Sleep Disorders; Social Behavior; Social Functioning; Social Network; Support System; Time; Work; abstracting; aging gene; behavioral health; data sharing; database of Genotypes and Phenotypes; genetic analysis; genetic resource; genetic technology; genome wide association study; mortality; psychologic; sex; social

DESCRIPTION (provided by applicant): This project will utilize high-throughput genetic technologies in a major longitudinal behavioral study and renew the biomedical research community by building scientific partnerships for the integration of behavioral and genetic science. The 7,000 individual participants to be genotyped will be added to a database of 13,000 being constructed under an earlier ARRA project. The Health and Retirement Study (HRS), begun in 1992, sets the standard for data-sharing and dissemination, with over 1,000 publications by over 1,000 different authors and co-authors. Its rich measurement across domains of health, psychological characteristics, social networks, and economic status and behavior creates an unparalleled body of phenotypic data observed over time that can now be paired with a rich genotypic characterization of a million SNPs using the Illumina Omni1-quad beadchip. Valuable as a replication sample for many established GWA studies, this resource, building on a study already widely known in behavioral aging research, will revolutionize research on behavioral science as one of the first large-scale studies to combine genetics with behavioral phenotypes, creating a platform for discovery. Specifically, this project aims to conduct genotyping through the Center for Inherited Disease Research (CIDR) on approximately 7,000 samples derived from saliva; to make the genotype data available through dbGaP with a limited array of phenotypes; to maintain a process for sharing genotype and broader phenotype data more widely in the research community; and to conduct a limited set of association studies with established phenotypes of cardiovascular health and cognition to demonstrate the potential of the data resource and serve as examples for future studies. The data and data-sharing mechanisms will be integrated into the ongoing HRS at the conclusion of this project. PUBLIC HEALTH RELEVANCE: This project will conduct genetic analysis on 16,000 individual participants in an ongoing longitudinal study of older Americans, and create mechanisms by which qualified researchers anywhere in the country can access the data for scientific analysis of health and behavior in the older population. It will conduct demonstration studies of genetic factors in cardiovascular health and in cognition.

描述（由申请人提供）：该项目将利用高通量遗传技术进行主要的纵向行为研究，并通过建立行为和遗传科学整合的科学伙伴关系来更新生物医学研究社区。7，000名参与者将被添加到一个由13，000人组成的数据库中，该数据库是根据早期的ARRA项目建立的。健康与退休研究（HRS）始于1992年，为数据共享和传播设定了标准，由1，000多名不同的作者和合著者发表了1，000多篇出版物。它在健康、心理特征、社交网络以及经济状况和行为等领域的丰富测量创建了一个无与伦比的表型数据库，随着时间的推移观察到的表型数据库现在可以与使用Illumina Omni 1-quad微珠芯片的一百万个SNP的丰富基因型表征配对。作为许多既定的GWA研究的复制样本，这一资源是建立在行为老化研究中已经广为人知的研究基础上的，它将彻底改变行为科学研究，成为将遗传学与行为表型联合收割机结合起来的首批大规模研究之一，为发现创造一个平台。具体而言，该项目旨在通过遗传疾病研究中心对约7 000份唾液样本进行基因分型;通过dbGaP提供有限表型的基因型数据;保持在研究界更广泛地分享基因型和更广泛表型数据的进程;并进行有限的一组与心血管健康和认知的既定表型的关联研究，以证明数据资源的潜力，并作为未来研究的例子。在该项目结束时，数据和数据共享机制将被纳入正在进行的人力资源系统。 公共卫生相关性：该项目将对正在进行的美国老年人纵向研究中的16，000名个体参与者进行遗传分析，并建立机制，使全国任何地方的合格研究人员都可以访问数据，对老年人的健康和行为进行科学分析。它将对心血管健康和认知方面的遗传因素进行示范研究。