1/2 Development of a Screening Interview for Research Studies of ASD
1/2 开发 ASD 研究筛选访谈
基本信息
- 批准号:7940793
- 负责人:
- 金额:$ 66.51万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2009
- 资助国家:美国
- 起止时间:2009-09-30 至 2012-08-31
- 项目状态:已结题
- 来源:
- 关键词:AddressAdolescentAdultAdvisory CommitteesAgeAge of OnsetAlgorithmsAmerican Psychological AssociationAnxietyAnxiety DisordersAppointmentAreaAttention deficit hyperactivity disorderAuthorshipAutistic DisorderBehaviorBehavioralBrainChildClinicClinicalClinical ResearchCollectionCommunicationCommunication impairmentCommunitiesDataData CollectionData SetDatabasesDecision MakingDevelopmentDevice or Instrument DevelopmentDiagnosisDiagnosticDiagnostic and Statistical ManualDisciplineDiseaseDoctor of PhilosophyDown SyndromeEffectivenessElectronic MailEligibility DeterminationEnsureEtiologyEvaluationExhibitsFaceFacultyFamilyFellowshipFetal Alcohol SyndromeFollow-Up StudiesFoundationsFragile X SyndromeFundingGeneticGenetic screening methodGrowth and Development functionHousingHumanIndividualInfantIntellectual functioning disabilityInterventionInterviewInvestigationJointsKnowledgeLanguageLanguage DelaysLeadLeadershipLocationLongitudinal StudiesMeasuresMedical centerMethodsMichiganNational Institute of Mental HealthNational Institute on Deafness and Other Communication DisordersNew YorkPaperParentsParticipantPatientsPediatric HospitalsPediatricsPersonsPhenotypePhysiciansPopulationPositioning AttributePostdoctoral FellowPreschool ChildPrincipal InvestigatorProbabilityProblem behaviorProceduresPropertyPsychiatryPsychologyQualifyingQuestionnairesRandomized Controlled TrialsRecommendationRecordsRecruitment ActivityReportingResearchResearch DesignResearch Ethics CommitteesResearch PersonnelResearch Project GrantsResourcesRiskRoleSamplingSchool-Age PopulationScreening procedureSensitivity and SpecificityServicesSiteSourceSpecial EducationSpecificitySpeedStudentsSubgroupSymptomsTeleconferencesTelephoneTestingTimeToddlerTrainingTravelTriageUnited States Health Resources and Services AdministrationUnited States National Institutes of HealthUniversitiesValidationVisitWalkingWisconsinWorkautism spectrum disorderbaseclinical Diagnosisconflict resolutionexperiencegraduate studentinstrumentinterestmedical specialtiesmeetingsnew technologyphrasesprofessorprogramspublic health relevancerepositoryresearch studyresponseservice interventionsocialsocial communicationteachertertiary carevirtual
项目摘要
DESCRIPTION (provided by applicant): To enhance participant recruitment efforts for genetics studies and other large- scale etiological research efforts, there is a need for an instrument that can be practically and efficiently employed in research studies of autism spectrum disorders (ASD). The current proposal aims to develop a research screening instrument that is based on questions from the Autism Diagnostic Interview-Revised (ADI-R; Rutter et al., 2003), but that is substantially shorter and easier to administer. The newly developed ADI Research Screening Interview will be appropriate for use in person or on the telephone. Development of the ADI Research Screening Interview will involve two large samples of children with ASD and non-ASD diagnoses. Existing data from a total of 979 assessments of children with ASD and 257 assessments of children with non-ASD diagnoses will be used to develop the instrument. A separate group of approximately 180 participants with ASD and 240 with non-ASD diagnoses will be recruited from ongoing research studies and specialty diagnostic clinics to test the new measure. Given recent findings that children with certain non-ASD diagnoses are often misclassified by ASD screening and diagnostic measures (e.g., Towbin et al., 2005; Bishop, et al., 2007), a particular strength of this proposal is the recruitment of children with targeted non-ASD diagnoses, including intellectual disability (ID), attention deficit hyperactivity disorder (ADHD), anxiety disorder, and an early developmental risk group. With the advent of new technologies making genetic testing more accessible and less expensive, researchers are increasingly calling for a way to rapidly screen large populations for ASD first, and then carry out more intensive phenotyping after genetic tests are analyzed. The availability of a diagnostic screening instrument with high levels of sensitivity and specificity will dramatically reduce the time and expense that is currently required to determine diagnostic status of ASD research participants. The option of administering the screening protocol by telephone will facilitate access to more diverse participant populations for whom travel may be less feasible and who are traditionally under-represented in ASD research.
PUBLIC HEALTH RELEVANCE: This proposal will result in the development of a new screening instrument to identify children with autism spectrum disorders (ASD). Several investigations are currently underway in order to better understand the causes of ASD. Many of these studies require very large numbers of participants; however, current methods for identifying participants for such studies are often expensive and time-consuming and require intensive training. To address these issues, we aim to create a short parent interview that can be administered on the telephone to quickly identify potential participants for ASD research. This new instrument will facilitate research into ASD etiology by increasing the speed and effectiveness of participant recruitment efforts. In addition, such an instrument may have other practical uses clinically. In communities where the wait for an ASD evaluation is extremely long or there are no local resources for diagnostic evaluations, an efficient screening instrument that could be administered by phone might help triage children in need of further evaluation and/or be used to qualify children for certain intervention services pending a more complete diagnostic evaluation at a later time.
描述(由申请人提供):为了加强遗传学研究和其他大规模病因学研究的参与者招募工作,需要一种可以实际有效地用于自闭症谱系障碍(ASD)研究的工具。目前的提案旨在开发一种研究筛选工具,该工具基于自闭症诊断访谈-修订版(ADI-R; Rutter et al.,2003年),但这是大大缩短,更容易管理。新开发的ADI研究筛选面试适合亲自或通过电话进行。 ADI研究筛选访谈的开发将涉及ASD和非ASD诊断儿童的两个大样本。来自979名ASD儿童评估和257名非ASD诊断儿童评估的现有数据将用于开发该工具。另一组约180名ASD患者和240名非ASD诊断患者将从正在进行的研究和专业诊断诊所招募,以测试新措施。鉴于最近的发现,患有某些非ASD诊断的儿童经常被ASD筛查和诊断措施(例如,Towbin等人,2005; Bishop等人,2007年),该提案的一个特别优势是招募有针对性的非ASD诊断的儿童,包括智力残疾(ID),注意力缺陷多动障碍(ADHD),焦虑症和早期发育风险组。 随着新技术的出现,使基因检测更容易获得和更便宜,研究人员越来越多地呼吁一种方法,首先快速筛选ASD的大群体,然后在基因检测分析后进行更密集的表型分析。具有高水平的灵敏度和特异性的诊断筛查仪器的可用性将大大减少目前确定ASD研究参与者的诊断状态所需的时间和费用。通过电话管理筛选方案的选择将有助于获得更多样化的参与者人群,对他们来说,旅行可能不太可行,并且传统上在ASD研究中代表性不足。
公共卫生相关性:该提案将导致开发一种新的筛查工具,以识别自闭症谱系障碍(ASD)儿童。目前正在进行一些调查,以更好地了解ASD的原因。许多这些研究需要非常大量的参与者,然而,目前的方法来确定参与者的研究往往是昂贵的,耗时的,需要密集的培训。为了解决这些问题,我们的目标是创建一个简短的家长访谈,可以在电话上管理,以快速识别ASD研究的潜在参与者。这种新的工具将通过提高参与者招募工作的速度和有效性来促进ASD病因学的研究。此外,这种仪器在临床上可能有其他实际用途。在ASD评估等待时间极长或没有本地资源进行诊断评估的社区,可以通过电话管理的有效筛查工具可能有助于对需要进一步评估的儿童进行分类和/或用于使儿童有资格获得某些干预服务,以等待稍后进行更完整的诊断评估。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Christopher Stephen Monk其他文献
Christopher Stephen Monk的其他文献
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{{ truncateString('Christopher Stephen Monk', 18)}}的其他基金
Effects of poverty on affective development: A multi-level, longitudinal study
贫困对情感发展的影响:多层次、纵向研究
- 批准号:
9075688 - 财政年份:2015
- 资助金额:
$ 66.51万 - 项目类别:
Effects of poverty on affective development: A multi-level, longitudinal study
贫困对情感发展的影响:多层次、纵向研究
- 批准号:
8904276 - 财政年份:2014
- 资助金额:
$ 66.51万 - 项目类别:
Effects of poverty on affective development: A multi-level, longitudinal study
贫困对情感发展的影响:多层次、纵向研究
- 批准号:
8690209 - 财政年份:2014
- 资助金额:
$ 66.51万 - 项目类别:
Effects of poverty on affective development: A multi-level, longitudinal study
贫困对情感发展的影响:多层次、纵向研究
- 批准号:
9064843 - 财政年份:2014
- 资助金额:
$ 66.51万 - 项目类别:
Brain Markers of Anxiety Disorders and SSRI Treatment in Children and Adolescents
儿童和青少年焦虑症的脑标志物和 SSRI 治疗
- 批准号:
7991966 - 财政年份:2010
- 资助金额:
$ 66.51万 - 项目类别:
Brain Markers of Anxiety Disorders and SSRI Treatment in Children and Adolescents
儿童和青少年焦虑症的脑标志物和 SSRI 治疗
- 批准号:
8240081 - 财政年份:2010
- 资助金额:
$ 66.51万 - 项目类别:
Brain Markers of Anxiety Disorders and SSRI Treatment in Children and Adolescents
儿童和青少年焦虑症的脑标志物和 SSRI 治疗
- 批准号:
8433431 - 财政年份:2010
- 资助金额:
$ 66.51万 - 项目类别:
Brain Markers of Anxiety Disorders and SSRI Treatment in Children and Adolescents
儿童和青少年焦虑症的脑标志物和 SSRI 治疗
- 批准号:
8102062 - 财政年份:2010
- 资助金额:
$ 66.51万 - 项目类别:
Development of a Brief Screener for Research in Autism Spectrum Disorders
开发用于自闭症谱系障碍研究的简短筛选器
- 批准号:
7940917 - 财政年份:2009
- 资助金额:
$ 66.51万 - 项目类别:
Adolescent Social Phobia and Neurophysiological Function
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- 批准号:
6617116 - 财政年份:2005
- 资助金额:
$ 66.51万 - 项目类别:
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