Development of a Brief Screener for Research in Autism Spectrum Disorders

描述（由申请人提供）：本申请题为“自闭症谱系障碍研究的简要筛选器的开发”，涉及广泛的挑战领域（04）临床研究，04-MH-101* 自闭症：解决挑战。该提案旨在开发一种基于社会沟通问卷（SCQ：Rutter，Bailey，& Lord，2003）和自闭症诊断访谈-修订版（ADI-R; Rutter，LeCouteur & Lord，2003）中的问题的研究筛选工具，可以更有效和更实际地用于自闭症谱系障碍（ASD）的研究。新开发的措施将是ADI研究筛选问卷，这是一个简短的父母报告工具，旨在识别2至18岁儿童的ASD。新措施的开发和验证将涉及来自美国多个地点的两个非常大的儿童群体，现有数据来自对ASD儿童的2293项评估，对非ASD诊断儿童的792项评估，以及600名ASD儿童的典型发展兄弟姐妹将构成测量发展样本的基础。将从正在进行的研究和专业诊断诊所招募1340名ASD参与者，510名非ASD诊断参与者和200名ASD儿童的典型发展兄弟姐妹的单独样本，以验证新开发的措施。对这两个独立样本的数据分析将产生一种新的工具，可用于快速确定ASD研究的潜在参与者。快速准确区分ASD儿童与其他发育障碍儿童的措施的可用性对于病因学和流行病学研究工作将是非常宝贵的，因为它将显着减少目前指定研究参与者为患有或未患有ASD所需的时间和费用。开发自闭症谱系障碍研究的简要筛选器该项目将导致开发一种新的筛选仪器，可用于自闭症谱系障碍（ASD）的研究。由于需要识别大量的参与者进行遗传学研究和其他ASD原因的调查，研究人员需要一种方法来快速筛查大量儿童并识别那些极有可能诊断为ASD的儿童。该项目将为研究人员提供快速选择潜在参与者的能力，以便他们能够更有效地对ASD的原因进行调查。

DESCRIPTION (provided by applicant): This application entitled "Development of a Brief Screener for Research in Autism Spectrum Disorders" addresses broad challenge area (04) Clinical Research, 04-MH-101* Autism: Addressing the challenge. The proposal aims to develop a research screening instrument based on questions from the Social Communication Questionnaire (SCQ: Rutter, Bailey, & Lord, 2003) and the Autism Diagnostic Interview- Revised (ADI-R; Rutter, LeCouteur & Lord, 2003) that can be more effectively and practically employed in research studies of autism spectrum disorders (ASD). The newly developed measure will be the ADI Research Screening Questionnaire, a brief parent-report instrument that is designed to identify ASD in children ages 2 to 18 years. Development and validation of the new measure will involve two very large groups of children from multiple sites across the U.S. Existing data from a total of 2293 assessments of children with ASD, 792 assessments of children with non-ASD diagnoses, and 600 typically developing siblings of children with ASD will form the basis of the Measure Development sample. A separate sample of 1340 participants with ASD, 510 participants with non-ASD diagnoses, and 200 typically developing siblings of children with ASD will be recruited from ongoing research studies and specialty diagnostic clinics to validate the newly developed measure. Analyses of data from these two independent samples will result in a new instrument that can be used to rapidly ascertain potential participants for ASD research. The availability of a measure that quickly and accurately differentiates children with ASD from children with other developmental disorders will be invaluable to etiological and epidemiological research efforts, as it will significantly reduce the time and expense that is currently required to designate study participants as either having or not having ASD. Development of a Brief Screener for Research in Autism Spectrum Disorders This project will result in the development of a new screening instrument that can be used for research studies of autism spectrum disorders (ASD). Because of the need to identify large numbers of participants for genetics studies and other investigations of the causes of ASD, researchers require a way to rapidly screen large numbers of children and identify those who are highly likely to have a diagnosis of ASD. This project will provide researchers with the ability to quickly select potential participants so that they can more effectively carry out their investigations into the causes of ASD.