Adolescent Social Phobia and Neurophysiological Function

青少年社交恐惧症与神经生理功能

• 批准号: 6617116
• 负责人: Christopher Stephen Monk
• 金额: $ 14.1万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-09-30 至 2007-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6617116
• 关键词: adolescence (12-20); anxiety; behavioral /social science research tag; bioimaging /biomedical imaging; brain mapping; face expression; fear; functional magnetic resonance imaging; human subject; middle childhood (6-11); neuropsychological tests; neuropsychology; patient oriented research; phobias; social adjustment

DESCRIPTION (provided by applicant): The goal of this Research Career Award is to develop the applicant's ability to conduct independent translationally oriented clinical research. The applicant is trained in experimental methodology, child psychology and neuroscience. This background enables the applicant to critically review the relevant literature and develop methodological procedures based on neuroscience models that can be adapted to study brain function in children. This grant would provide the training and mentoring necessary for the applicant to use these methods and theories to begin to reveal the neural correlates of developmental psychopathology. The applicant will be mentored in child psychiatry, psychiatric diagnostic procedures and in the use of adapting neuroimaging procedures for the study of psychiatric disorders. Animal research provides an effective pathophysiological model for anxiety. Using fear provoking paradigms, animal model approaches delineate a neural circuit that includes the amygdala and the orbito-frontal cortex in anxiety-related behaviors. Research in adults with anxiety disorders documents perturbations in the same regions in response to fear provoking stimuli, particularly emotionally evocative faces. However, very little work has been conducted to document comparable perturbations in adolescents with anxiety. The research objective for the present proposal is to use animal models of anxiety as a guide to reveal the neurophysiological and behavioral correlates of adolescent social phobia. Specifically, healthy adolescents and those with social phobia will be presented with fear provoking stimuli (emotional faces), while brain activation is measured with functional magnetic resonance imaging. Such work will help to reveal the neurophysiological correlates of adolescent social phobia. The long-term goal is to identify neurobiological and behavioral events that underlie the development of childhood anxiety disorders.

描述（由申请人提供）：该研究职业奖的目标是培养申请人进行独立的转化型临床研究的能力。申请人接受过实验方法、儿童心理学和神经科学方面的培训。这一背景使申请人能够批判性地审查相关文献，并开发基于神经科学模型的方法程序，这些模型可适用于研究儿童的大脑功能。这笔赠款将为申请人提供必要的培训和指导，以使用这些方法和理论来开始揭示发展精神病理学的神经相关性。申请人将接受儿童精神病学、精神病诊断程序以及使用神经影像学程序进行精神疾病研究方面的指导。 动物研究为焦虑提供了有效的病理生理学模型。使用引发恐惧的范例，动物模型方法描绘了一个神经回路，其中包括与焦虑相关的行为中的杏仁核和眶额皮质。对患有焦虑症的成年人进行的研究记录了同一区域对引起恐惧的刺激（尤其是令人情绪激动的面孔）的反应。然而，很少有工作来记录焦虑青少年的类似困扰。本提案的研究目标是使用焦虑动物模型作为指导，揭示青少年社交恐惧症的神经生理学和行为相关性。具体来说，健康的青少年和患有社交恐惧症的人将受到引起恐惧的刺激（情绪面孔），同时通过功能磁共振成像测量大脑激活情况。此类工作将有助于揭示青少年社交恐惧症的神经生理学相关性。长期目标是确定导致儿童焦虑症发展的神经生物学和行为事件。