Linguistic and NonLinguistic Functions of Frontal Cortex

额叶皮层的语言和非语言功能

• 批准号: 7849895
• 负责人: SHARON L THOMPSONSCHILL
• 金额: $ 27.85万
• 依托单位: UNIVERSITY OF PENNSYLVANIA
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-07-17 至 2012-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7849895
• 关键词: Accounting; Address; Affect; Area; Brain region; Broca' s area; Cognitive; Complement component C1s; Comprehension; Conflict (Psychology); Dependence; Development; Disease; Face; Faculty; Familiarity; Functional Magnetic Resonance Imaging; Grant; Human; Impairment; Inferior frontal gyrus; Investigation; Language; Language Disorders; Lead; Left; Lesion; Linguistics; Link; Literature; Memory impairment; Mental disorders; Methods; Nature; Operative Surgical Procedures; Paint; Physiological; Prefrontal Cortex; Process; Progress Reports; Research; Research Personnel; Research Support; Resolution; Rest; Retrieval; Role; Semantics; Short-Term Memory; Specificity; Structure; Testing; Transcranial magnetic stimulation; base; brain behavior; cognitive control; frontal lobe; information processing; interdisciplinary approach; language processing; meetings; millimeter; neurophysiology; neuropsychological; phonology; programs; relating to nervous system; syntax; theories; tool

DESCRIPTION (provided by applicant): What is the relationship between the human faculty for language and the many other, nonlinguistic cognitive abilities we possess? For the past decade, our research team has explored this important question by focusing on a place (quite literally) where linguistic and nonlinguistic processes seem to "meet": Broca's area. Long described of as the seat of some linguistic specialization, Broca's area may have more in common with the rest of prefrontal cortex than is typically thought. Motivated by an extensive literature on the regulatory functions of prefrontal cortex, we have developed a framework for considering the role of Broca's area - a part of prefrontal cortex - in language processing. We argue that Broca's area functions to bias competitive interactions among representations of many types (including semantic, phonological, and syntactic). As such, the relationship between Broca's area and linguistic function cannot be captured by studying a single domain (such as syntax) but rather requires the broad, interdisciplinary approach represented in our research program and exemplified by the divergent expertise of our research team. In the coming years of this research program, we hope to continue our multi-method investigations of linguistic and nonlinguistic functions of prefrontal cortex. The major aims of the research plans outlined in the current proposal are as follows: (1) to continue our investigations of the role of LIFG in language processing; (2) to better characterize the role of LIFG in working memory; (3) to evaluate the relation between working memory, language, and cognitive control and the nature of their dependence on LIFG; and, (4) to develop new tools for inferring causal structure-function relations. This research program has relevance to disorders of mental health (specifically, attentional disorders) and to disorders of language, by virtue of the fact that it highlights the important links between these two seemingly disparate functions.

描述（由申请人提供）：人类的语言能力和我们拥有的许多其他非语言认知能力之间的关系是什么？在过去的十年里，我们的研究团队通过关注语言和非语言过程似乎“相遇”的地方来探索这个重要的问题：布罗卡区。布罗卡区长期以来被描述为某些语言专门化的所在地，它与前额叶皮层的其他部分可能比通常认为的更相似。受大量关于前额叶皮层调节功能的文献的启发，我们已经开发了一个框架来考虑Broca区-前额叶皮层的一部分-在语言处理中的作用。我们认为，布罗卡区的功能，以偏见竞争的相互作用之间的代表性的许多类型（包括语义，语音和句法）。因此，布洛卡区和语言功能之间的关系无法通过研究单个领域（例如语法）来捕捉，而是需要我们的研究计划中所代表的广泛的跨学科方法，并以我们研究团队的不同专业知识为例。在未来几年的研究计划中，我们希望继续我们的多方法研究的语言和非语言功能的前额叶皮层。本研究计划的主要目标是：（1）继续研究LIFG在语言加工中的作用;（2）更好地描述LIFG在工作记忆中的作用;（3）评价工作记忆、语言和认知控制之间的关系以及它们对LIFG的依赖性;（4）进一步研究LIFG在工作记忆中的作用。（4）开发新的工具来推断因果结构-功能关系。这项研究计划与精神健康障碍（特别是注意力障碍）和语言障碍有关，因为它突出了这两种看似不同的功能之间的重要联系。