University of California, Irvine Cancer Center Support Grant

加州大学欧文分校癌症中心支持补助金

• 批准号: 7923066
• 负责人: FRANK L. MEYSKENS
• 金额: $ 6.18万
• 依托单位: UNIVERSITY OF CALIFORNIA-IRVINE
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-09-11 至 2012-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7923066
• 关键词: Area; Biology; Biometry; Breast; California; Cancer Center; Cancer Center Support Grant; Cancer Control; Cancer Control Research; Cancer Model; Cervical Melanoma; Chemoprevention; Clinical; Clinical Research; Comprehensive Cancer Center; County; DNA Damage; Developmental Biology; Diagnosis; Division of Basic Sciences; Epidemiologic Studies; Funding; Genotype; Goals; Growth Factor; Investigation; Laboratories; Malignant Neoplasms; Malignant neoplasm of prostate; Mass Spectrum Analysis; Molecular Biology; Mutation; Nature; Optics; Oranges; Oxidative Stress; Participant; Peer Review; Phenotype; Pilot Projects; Population; Population Sciences; Prevention; Prevention strategy; Process; Prostate; Protein Microchips; Proteins; Reporting; Research; Research Activity; Resource Sharing; Screening for cancer; Signal Transduction; Societies; Spectrum Analysis; Stem Cell Research; Stem cells; Students; Supportive care; Therapeutic; Tissues; Training; Training and Education; Transgenic Mice; Translating; Translations; Universities; University of California Irvine Cancer Center; anticancer research; base; biobehavior; cancer initiation; cancer risk; cancer therapy; carcinogenesis; in vivo; interest; malignant breast neoplasm; member; multidisciplinary; oncology; programs; response; science education; socioeconomics; tumor; tumor progression; viral carcinogenesis; working group

DESCRIPTION (provided by applicant): The University of California, Irvine Comprehensive Cancer Center is the only NCI-designated Comprehensive Cancer Center in Orange County and is a matrix-type organization. The Cancer Center serves approximately three million people in Orange County. The research goals of the Cancer Center are: 1) To contribute to the understanding of basic mechanisms that underlie the phenotype and genotype of cancer; 2) To facilitate the translation of laboratory and epidemiologic research into hypothesis-driven clinical prevention and treatment studies; 3) To conduct clinical prevention trials, whenever possible emanating from research generated in the Center; 4) To define cancer risk in the diverse socioeconomic and multicultural society served by the Center and to develop research strategies to facilitate the prevention and early detection of cancer in these populations; and 5) To utilize the extensive education and training opportunities available at all levels as a major translational vehicle and to encourage activities that promote interdisciplinary, multidisciplinary, and transdisciplinary research. The Center is organized into four major Divisions: Basic Sciences, Clinical Research, Cancer Control & Population Sciences, and Education & Training. The Divisions interact through seven research programs: Carcinogenesis, Developmental Biology, Growth Factors & Signaling, Onco-lmaging & Spectroscopy, Population Sciences, Structural Molecular Biology, and Translational Oncology. The Center provides centralized support for Program functions through ten Shared Resource Facilities: Biobehavioral, Biostatistics, Clinical Research Office, DMA Sequencing, DMA & Protein MicroArray, Experimental Tissue, In-Vivo Functional Onco-lmaging, Optical Biology, Protein Mass Spectrometry, and Transgenic Mouse. The Education & Training Division facilitates integration of students into basic, clinical, and cancer control research activities in the various programs and accordingly enhances the translational capabilities of the Center. The 143 full Members of the Center are currently supported by $11,909,249 in direct NCI funds. Of the overall direct total of cancer-related funding ($36,214,529), $30,665,383 is peer-reviewed and $5,549,146 is non-peer-reviewed. Cancer Center Members entered 202 participants on prevention, therapeutic, and supportive care trials in the 2006-07 reporting year.

描述（申请人提供）：加州大学欧文综合癌症中心是奥兰治县唯一一家NCI指定的综合癌症中心，是一个矩阵型组织。癌症中心为奥兰治县大约 300 万人提供服务。癌症中心的研究目标是： 1) 有助于理解癌症表型和基因型的基本机制； 2）促进实验室和流行病学研究转化为假设驱动的临床预防和治疗研究； 3) 尽可能根据中心的研究开展临床预防试验； 4) 确定中心服务的多元化社会经济和多元文化社会中的癌症风险，并制定研究策略以促进这些人群中癌症的预防和早期发现； 5) 利用各级提供的广泛教育和培训机会作为主要的转化工具，并鼓励促进跨学科、多学科和跨学科研究的活动。 该中心分为四个主要部门：基础科学、临床研究、癌症控制与人口科学以及教育与培训。这些部门通过七个研究项目进行互动：癌发生、发育生物学、生长因子和信号传导、肿瘤成像和光谱学、人口科学、结构分子生物学和转化肿瘤学。该中心通过十个共享资源设施为项目功能提供集中支持：生物行为、生物统计学、临床研究办公室、DMA 测序、DMA 和蛋白质微阵列、实验组织、体内功能性肿瘤成像、光学生物学、蛋白质质谱和转基因小鼠。教育培训部促进学生融入各个项目的基础、临床和癌症控制研究活动，从而增强中心的转化能力。 该中心的 143 名正式会员目前获得 11,909,249 美元的 NCI 直接资金支持。在癌症相关资金的直接总额（36,214,529 美元）中，30,665,383 美元经过同行评审，5,549,146 美元未经同行评审。癌症中心成员在 2006-07 报告年度招募了 202 名参与者参加预防、治疗和支持性护理试验。