RENAL CYTOCHROME P450 EPOXYGENASE IN DIABETIC METABOLIC SYNDROME

糖尿病代谢综合征中的肾细胞色素 P450 环氧合酶

• 批准号: 8166169
• 负责人: Xueying Zhao
• 金额: $ 8.79万
• 依托单位: MOREHOUSE SCHOOL OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-06-01 至 2011-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8166169
• 关键词: Computer Retrieval of Information on Scientific Projects Database; Cytochrome P450; Development; Diabetic Nephropathy; Epithelial; Functional disorder; Funding; Goals; Grant; Injury; Institution; Kidney; Metabolic syndrome; Research; Research Personnel; Resources; Source; United States National Institutes of Health; diabetic; kidney vascular structure; research study

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Specific Aims The overall goal of this project remains the same and is to elucidate the regulatory mechanism(s) and functional consequences of cytochorme P450 (CYP) epoxygenase metabolites (EETs) in the development and progression of vascular and renal dysfunction related to diabetic metabolic syndrome. Experiments performed over the project period have resulted in significant progress on the three Specific Aims. In addition, we have expanded our recent studies to determine glomerular epithelial injury in progressive diabetic nephropathy.

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 具体目标 本项目的总体目标保持不变，旨在阐明细胞色素P450（CYP）表氧化酶代谢物（E132）在糖尿病代谢综合征相关血管和肾功能障碍的发生和进展中的调节机制和功能后果。在项目期间进行的实验在三个具体目标方面取得了重大进展。此外，我们扩大了我们最近的研究，以确定肾小球上皮损伤的进展性糖尿病肾病。