NMR Imaging and Spectroscopy

描述（由申请人提供）：明尼苏达大学磁共振研究中心是一个跨部门和跨学科的研究实验室，在过去的十三年里被资助为生物技术研究资源（BTRR）。BTRR的核心研究重点是开发和改进高磁共振成像和光谱学的方法和技术，并提供最先进的仪器、专业知识和基础设施，使美国和国外几家机构的教师、学员和工作人员能够利用这些独特的高磁场（4至16.4特斯拉）能力开展基础和应用生物医学研究。本申请的总体目标是寻求对生物医学技术研究资源的持续支持，以追求新的方法和技术发展，并保持具有其他地方不易获得的独特仪器和专业知识的国家研究资源。核心项目的一个中心和主要目标是开发技术，利用高磁场提供的独特优势，如高信噪比，与血液相关的敏感性效应增加，用于成像脑功能，更长的T1s用于测量组织灌注，同时获得人体器官功能，灌注，氧气提取，代谢和解剖等方面的无创信息。提高化学位移分辨率，以改进神经化学物质的检测，并使用生物活性原子的磁性同位素，如O-17，由于其低回旋磁比，在低磁场下不易获得。这些技术已经并将继续用于支持NIH资助的神经科学、脑功能测绘、脑代谢、代谢紊乱、心脏病理学和生物能量学等领域的大型研究人员。

DESCRIPTION (provided by applicant): Center for Magnetic Resonance Research at the University of Minnesota is an interdepartmental and interdisciplinary research laboratory that has been funded as a Biotechnology Research Resource (BTRR) during the last thirteen years. The central research focus of this BTRR is development and improvement of methodologies and technologies for high magnetic resonance (MR) imaging and spectroscopy, and providing state-of-the-art instrumentation, expertise and infrastructure to enable the faculty, trainees and staff of several institutions in the USA and abroad to carry out basic and applied biomedical research that utilizes these unique high magnetic field (4 to 16.4 Tesla) capabilities. The general aim of this application is to seek continued support for this Biomedical Technology Research Resource so as to pursue new methodological and technical developments and maintain a National Research Resource with unique instrumentation and expertise that is not readily available elsewhere. A central and primary aim of the Core projects is to develop techniques for obtaining simultaneous information on aspects of organ function, perfusion, oxygen extraction, metabolism, and anatomy in humans non-invasively, using the unique advantages provided by high magnetic fields, such as the high signal-to-noise ratio, increased susceptibility effects associated with blood for imaging brain function, longer T1s for measurement of tissue perfusion, increased chemical-shift resolution for improved detection of neurochemicals, and the use of magnetic isotopes of biologically active atoms, such as O-17, which are not accessible easily at low magnetic fields due to their low gyromagnetic ratio. These techniques have been and will continue to be utilized to support a large community of NIH funded researchers working in neurosciences, functional brain mapping, brain metabolism, metabolic disorders, and cardiac pathology and bioenergetics. Overview of the Program: This is a m