Immune tolerance network: Rheumatoid arthritis

免疫耐受网络：类风湿性关节炎

• 批准号: 8147303
• 负责人: JEFFREY BLUESTONE
• 金额: $ 30.35万
• 依托单位: UNIVERSITY OF SAN FRANCISCO
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-09-30 至 2014-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8147303
• 关键词: Arts; Autoimmune Diseases; Biological Assay; Clinical Research; Conduct Clinical Trials; Human; Immune Tolerance; Immune response; Immune system; Maintenance; Measures; Monitor; Rheumatoid Arthritis; laboratory facility; novel; prevent; research clinical testing

The Immune Tolerance Network is dedicated to the clinical evaluation of novel tolerance-inducing therapies that will ¿re-educate¿ the immune system to eliminate injurious immune responses. The ITN is conducting clinical trials in autoimmune diseases such as rheumatoid arthritis. In addition, to understand the underlying mechanisms of action of the candidate therapies and to monitor tolerance, the ITN has established state of the art core laboratory facilities to conduct integrated mechanistic studies and clinical research to develop and evaluate markers and assays to measure induction, maintenance, and loss of tolerance in humans.

免疫耐受网络致力于新的耐受诱导疗法的临床评估，这些疗法将重新教育免疫系统以消除有害的免疫反应。ITN正在进行类风湿性关节炎等自身免疫性疾病的临床试验。此外，为了了解候选疗法的潜在作用机制并监测耐受性，ITN建立了最先进的核心实验室设施，以进行综合机制研究和临床研究，开发和评价标记物和测定法，以测量人类耐受性的诱导、维持和丧失。