Immune tolerance network: liver transplantation
Immune tolerance network: liver transplantation
批准号:
8522028
负责人:
JEFFREY BLUESTONE
金额:
$334.6万
依托单位国家:
美国
项目类别:
财政年份:
2001
资助国家:
美国
项目状态:
已结题
起止时间:
2001-09-30 至 2014-04-30
中文摘要
免疫耐受网络致力于新型耐受诱导疗法的临床评估,这些疗法将“再教育”免疫系统以消除有害的免疫反应和移植物排斥反应。ITN开展临床试验,包括新的肝移植耐受诱导疗法和预防移植排斥反应。此外,为了了解候选疗法的潜在作用机制并监测耐受性,ITN建立了最先进的核心实验室设施,以进行综合机制研究,并开发和评估标记物和测定方法,以测量人类耐受性的诱导、维持和丧失。
英文摘要
The Immune Tolerance Network is dedicated to the clinical evaluation of novel tolerance-inducing therapies that will ¿re-educate¿ the immune system to eliminate injurious immune responses and graft rejection. The ITN conducts clinical trials that include novel tolerance-inducing therapies for liver transplantation and the prevention of graft rejection. In addition, to understand the underlying mechanisms of action of the candidate therapies and to monitor tolerance, the ITN has established state of the art core laboratory facilities to conduct integrated mechanistic studies, and to develop and evaluate markers and assays to measure induction, maintenance, and loss of tolerance in humans.
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批准号:8348615
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项目类别:
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负责人:JEFFREY BLUESTONE
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批准号:8339403
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批准号:8730009
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资助金额:$350.85万
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批准号:8730011
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资助金额:$532.49万
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负责人:JEFFREY BLUESTONE
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依托单位:--
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批准号:8751932
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资助金额:$241.36万
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负责人:JEFFREY BLUESTONE
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批准号:8522030
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资助金额:$167.3万
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负责人:JEFFREY BLUESTONE
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批准号:8147309
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项目类别:
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资助金额:$60.69万
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财政年份:2001
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负责人:JEFFREY BLUESTONE
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批准号:8147303
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项目类别:
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资助金额:$30.35万
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财政年份:2001
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依托单位:
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批准号:8147305
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项目类别:
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资助金额:$30.35万
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财政年份:2001
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负责人:JEFFREY BLUESTONE
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依托单位:
Immune Tolerance Network: Food Allergy
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批准号:8147300
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项目类别:
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资助金额:$455.2万
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财政年份:2001
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负责人:JEFFREY BLUESTONE
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依托单位:
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批准号:8339401
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项目类别:
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资助金额:$393.27万
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财政年份:2001
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负责人:JEFFREY BLUESTONE
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依托单位:
Immune Tolerance Network: Systemic lupus erythematosus (SLE)
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批准号:8522029
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项目类别:
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资助金额:$167.3万
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财政年份:2001
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负责人:JEFFREY BLUESTONE
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依托单位:
Immune tolerance network: Islet cell transplantation
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批准号:8730016
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项目类别:
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资助金额:$37.32万
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财政年份:2001
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负责人:JEFFREY BLUESTONE
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依托单位:--
Immune Tolerance Network: Type 1 diabetes
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批准号:8522026
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项目类别:
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资助金额:$1171.09万
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财政年份:2001
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负责人:JEFFREY BLUESTONE
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依托单位:
Immune Tolerance Network: Type 1 diabetes
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批准号:8147301
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项目类别:
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资助金额:$1256.93万
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财政年份:2001
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负责人:JEFFREY BLUESTONE
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依托单位:
Immune tolerance network: Autoimmune diseases: Vasculitis
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批准号:8147304
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项目类别:
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资助金额:$30.35万
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财政年份:2001
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负责人:JEFFREY BLUESTONE
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依托单位:
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批准号:8339410
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项目类别:
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资助金额:$786.54万
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财政年份:2001
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负责人:JEFFREY BLUESTONE
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依托单位:
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资助金额:$501.9万
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财政年份:2001
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负责人:JEFFREY BLUESTONE
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依托单位:
Immune tolerance network: liver transplantation
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批准号:8730010
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项目类别:
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财政年份:2001
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负责人:JEFFREY BLUESTONE
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依托单位:--
海外基金