Immune tolerance network: kidney transplantation

免疫耐受网络：肾移植

• 批准号: 8522030
• 负责人: JEFFREY BLUESTONE
• 金额: $ 167.3万
• 依托单位: CALIFORNIA UNIV SAN FRANC
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-09-30 至 2014-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8522030
• 关键词: Biological Assay; Clinical Research; Conduct Clinical Trials; Graft Rejection; Human; Immune Tolerance; Immune response; Immune system; Kidney Transplantation; Maintenance; Measures; Monitor; Outcome; Prevention; improved; laboratory facility; novel; prevent; research clinical testing

The Immune Tolerance Network is dedicated to the clinical evaluation of novel tolerance-inducing therapies that will ¿re-educate¿ the immune system to eliminate injurious immune responses and graft rejection. The ITN conducts clinical trials that include novel tolerance-inducing therapies for kidney transplantation and the prevention of graft rejection. In addition, to understand the underlying mechanisms of action of the candidate therapies and to monitor tolerance, the ITN has established state of the art core laboratory facilities to conduct integrated mechanistic studies, and to develop and evaluate markers and assays to measure induction, maintenance, and loss of tolerance in humans. The Immune Tolerance Network conducts clinical trials and clinical research to prevent graft rejection and improve outcomes in kidney transplantation.

免疫耐受网络致力于新的耐受诱导疗法的临床评估，这些疗法将重新教育免疫系统以消除有害的免疫反应和移植排斥反应。ITN进行的临床试验包括新的诱导肾移植耐受的疗法和预防移植排斥。此外，为了了解候选疗法的潜在作用机制并监测耐受性，ITN建立了最先进的核心实验室设施，以进行综合机制研究，并开发和评价标记物和测定法，以测量人类耐受性的诱导、维持和丧失。 免疫耐受网络进行临床试验和临床研究，以防止移植排斥反应和改善肾移植的结果。