Immune Tolerance Network: Systemic lupus erythematosus (SLE)

免疫耐受网络：系统性红斑狼疮 (SLE)

• 批准号: 8730011
• 负责人: JEFFREY BLUESTONE
• 金额: $ 204.04万
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-09-30 至 2014-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8730011
• 关键词: Autoimmune Diseases; Biological Assay; Clinical Research; Conduct Clinical Trials; Human; Immune Tolerance; Immune response; Immune system; Lupus; Maintenance; Measures; Monitor; Systemic Lupus Erythematosus; laboratory facility; novel; prevent; research clinical testing

The Immune Tolerance Network is dedicated to the clinical evaluation of novel tolerance-inducing therapies that will ¿re-educate¿ the immune system to eliminate injurious immune responses. The ITN is conducting clinical trials in autoimmune diseases such as systemic lupus rythematosus (SLE). In addition, to understand the underlying mechanisms of action of the candidate therapies and to monitor tolerance, the ITN has established state of the art core laboratory facilities to conduct integrated mechanistic studies and clinical research to develop and evaluate markers and assays to measure induction, maintenance, and loss of tolerance in humans.

免疫耐受网络致力于新型耐受诱导疗法的临床评估，这些疗法将“再教育”免疫系统以消除有害的免疫反应。ITN正在进行自身免疫性疾病如系统性红斑狼疮（SLE）的临床试验。此外，为了了解候选疗法的潜在作用机制并监测耐受性，ITN建立了最先进的核心实验室设施，进行综合机制研究和临床研究，以开发和评估标志物和检测方法，以测量人类耐受性的诱导、维持和丧失。