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Immune tolerance network: liver transplantation

Immune tolerance network: liver transplantation
免疫耐受网络：肝移植
批准号：
8730010
负责人：
JEFFREY BLUESTONE
金额：
$114.46万
依托单位：
--
依托单位国家：
美国
项目类别：
财政年份：
2001
资助国家：
美国
项目状态：
已结题
起止时间：
2001-09-30 至 2014-04-30
来源：
https://reporter.nih.gov/project-details/8730010
关键词：
Biological AssayClinical ResearchConduct Clinical TrialsGraft RejectionHumanImmune ToleranceImmune responseImmune systemMaintenanceMeasuresMonitorOutcomePreventionimprovedlaboratory facilityliver transplantationnovelpreventresearch clinical testing

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中文摘要
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英文摘要
The Immune Tolerance Network is dedicated to the clinical evaluation of novel tolerance-inducing therapies that will ¿re-educate¿ the immune system to eliminate injurious immune responses and graft rejection. The ITN conducts clinical trials that include novel tolerance-inducing therapies for liver transplantation and the prevention of graft rejection. In addition, to understand the underlying mechanisms of action of the candidate therapies and to monitor tolerance, the ITN has established state of the art core laboratory facilities to conduct integrated mechanistic studies, and to develop and evaluate markers and assays to measure induction, maintenance, and loss of tolerance in humans.
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