Neurobehavior Core

神经行为(NB)核心是对资源、科学和领导力的补充和扩展 HNRC的目标是提高地方、国家和社区卫生服务的有效性和公共卫生影响 国际神经艾滋病研究。在前一个供资期间取得的成就的基础上，国家工作队 核心目的是提供：1)个人神经心理(NP)测量的表现分数，以及 临床和客观地得出NP功能的全球和领域特定评级；2)全球和领域特定 使用经过验证的临床和精算方法确定个体参与者的NP变化； 3)HIV相关神经认知障碍的共识诊断；4)认知和认知障碍的自我评估 日常生活中遇到的神经精神疾病和相关困难；5)当前和终生 情绪史和与物质相关的诊断；6)基于实验室的日常功能测量 能力，包括药物管理、工作相关能力和汽车驾驶；以及7)技术 协助、培训、认证、咨询和职业发展指导。世界银行的科学目标 NB的核心包括：1)提高关于神经行为影响的性质和程度的科学知识 2)审查艾滋病毒和老龄化对老年人和青少年的影响 前瞻记忆及相关的日常功能问题；3)促进发展 和实施有关神经行为影响的国内和国际研究工作 艾滋病毒和疾病是共同因素。创新之处包括：1)运用认知范式 神经心理学解释HIV认知缺陷的组成过程，这可能会改善 艾滋病毒相关神经认知障碍的检测和鉴别诊断；和2)继续 开发和验证与文化相关的神经行为工具，包括生成 少数群体和国际人口的规范性标准。总而言之，NB核心增强了 HNRC的资源、科学和临床相关性，通过关注与 艾滋病毒对认知、情感和适应功能的影响，这进一步增强了跨学科 重点关注艾滋病毒感染的生物(例如，神经病理)后果的科学核心的目标。

The Neurobehavioral (NB) Core complements and expands the resource, scientific, and leadership objectives of the HNRC in improving the effectiveness and public health impact of local, national, and international neuroAIDS research. Building on its accomplishments during the prior funding period, the NB Core aims to provide: 1) Performance scores on individual neuropsychological (NP) measures, as well as clinically and objectively derived global and domain-specific ratings of NP functioning; 2) global and domainspecific determinations of NP change in individual participants using validated clinical and actuarial methods; 3) consensus diagnoses of HIV-associated neurocognitive disorders; 4) self-assessment of cognitive and neuropsychiatric complaints and related difficulties experienced in everyday life; 5) current and lifetime history of mood and substance-related diagnoses; 6) laboratory-based measures of everyday functioning abilities, including medication management, work-related abilities and automobile driving; and 7) technical assistance, training, certification, consultation, and career development mentoring. The scientific aims of the NB Core include: 1) Advancing scientific knowledge on the nature and extent of the neurobehavioral effects of HIV disease in older adults and adolescents; 2) examining the impact of HIV and aging specifically on prospective memory and associated problems in everyday functioning; and 3) facilitating the development and implementation of national and international research efforts regarding the neurobehavioral effects of HIV and disease co-factors. Innovations include: 1) Utilization of paradigms derived from cognitive neuropsychology to elucidate the component processes of cognitive deficits in HIV, which may improve the detection and differential diagnosis of HIV-associated neurocognitive disorders; and 2) Continued development and validation of culturally relevant neurobehavioral instruments, including the generation of normative standards for minority and international populations. In summary, the NB Core enhances the resource, scientific, and clinical relevance of the HNRC by focusing on scientific questions related to the impact of HIV on cognitive, affective, and adaptive functions, which further augments the transdisciplinary aims of scientific Cores that focus on the biologic (e.g., neuropathological) consequences of HIV infection.