Neuromedical Core

神经医学核心(NMC)的总体目标是提供全面的临床和 实验室评估、科学咨询以及指导、培训和社区教育 神经艾滋病。在本供资期间，国家管理委员会协助了79个研究项目，其中包括观察性项目。 队列研究、临床病理调查、影像研究、临床试验和国际研究 由加州大学圣地亚哥分校和许多其他机构的合作调查人员执行。HNRC的合作 调查人员发现了NMC产生的数据，包括神经诊断配方、抗逆转录病毒 (ARV)治疗信息、HIV疾病分期信息、病毒载量和各种其他临床 实验室测量对其数据分析和出版至关重要。 认识到要保持活力和科学相关性，就必须不断适应 HNRC研究企业不断变化的需求及其许多负责人的科学议程 调查人员和合作者，我们建议从两个方面加强NMC在这次更新中的作用。首先，我们将 增加一个药理学部分，重点是抗逆转录病毒药物对CMS的渗透。第二，我们将 整合以前由细胞免疫学和流体核心执行的功能。新组建的 NMC由三个协作单元组成，每个协作单元包含公共资源(设备、 用品)和每天互动的工作人员：一个临床单位；一个病人来源的样本单位；以及一个 药理与生物标记物单位。核心将有助于回答的科学问题的例子有 1)共病原体和共病如丙型肝炎病毒在神经艾滋病中的作用是什么 (丙型肝炎病毒)和药物滥用？2)脑脊液(CSF)是否提供了一个有用的窗口来评估 神经艾滋病的病毒-宿主相互作用和分子发病机制？3)中枢神经系统在病毒中的作用 进化、适应与抗逆转录病毒耐药性的发生？4)宿主遗传学如何影响HIV 神经发病机制？ 通过在项目开发的所有级别协助广泛不同学科的调查人员，从 研究执行、分析、解释和传播的假设概念化， NMC鼓励应用多种科学观点，并促进跨学科 合作与协调。我们将与神经成像、神经行为、 以神经病毒学和神经生物学为核心，进一步促进跨学科目标。除了支持 在研究绩效方面，NMC还增强和延伸了研究的有效性和公开性 与心理健康和艾滋病毒/艾滋病有关的新发现对健康的影响。

The over-arching objectives of the Neuromedical Core (NMC) are to provide comprehensive clinical and laboratory evaluations, scientific consultation, and mentorship, training, and community education in NeuroAIDS. In the current funding period the NMC facilitated 79 research projects including observational cohort studies, clinical-pathological investigations, imaging studies, clinical trials and international research performed by collaborating investigators at UCSD and many other institutions. The HNRC's collaborating investigators find data generated by the NMC, including neurological diagnostic formulations, antiretroviral (ARV) treatment information, HIV disease staging information, viral loads and a variety of other clinical laboratory measurements, to be essential for their data analyses and publications. Recognizing that maintaining vitality and scientific relevance necessitates continual adaptation to the changing needs of the HNRC research enterprise and the scientific agendas of its many principal investigators and collaborators, we propose to enhance the NMC in this renewal in two ways. First, we will add a pharmacology component that will focus on ARV drug penetration into the CMS. Second, we will incorporate functions previously carried out by the Cellular Immunology and Fluids Core. The newly-organized NMC is made up of three cooperative units, each comprising common resources (equipment, supplies) and staff that interact on a daily basis: a Clinical Unit; a Patient-Derived Sample Unit; and a Pharmacology & Biomarker Unit. Examples of scientific questions the Core will facilitate answering are 1) What is the contributory role in neuroAIDS of co-pathogens and comorbidities such as hepatitis C virus (HCV) and substance abuse? 2) Does cerebrospinal fluid (CSF) provide a useful window to evaluate virus-host interactions and molecular pathogenesis in neuroAIDS? 3) What is the role of the CNS in viral evolution, adaptation and the occurrence of ARV drug resistance? 4) How do host genetics influence HIV neuropathogenesis? By assisting investigators in widely diverging disciplines at all levels of project development, from conceptualization of hypotheses to study implementation, analysis, interpretation and dissemination, the NMC encourages the application of multiple scientific perspectives and stimulates interdisciplinary collaboration and coordination. We will collaborate closely with the Neuroimaging, Neurobehavioral, Neurovirology and Neurobiology Cores to further stimulate transdisciplinary aims. In addition to supporting the performance of research research, the NMC also enhances and extends the effectiveness and public health impact of new findings related to mental health and HIV/AIDS.