Supporting New Faculty Recruitment Through BioMedical Research Core Center

通过生物医学研究核心中心支持新教师招聘

• 批准号: 7936145
• 负责人: David H Ingbar
• 金额: $ 54.11万
• 依托单位: UNIVERSITY OF MINNESOTA
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-09-30 至 2012-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7936145
• 关键词: Agmatine; Area; Basic Science; Biomedical Research; Clinical; Clinical Trials; Communicable Diseases; Complement; Critical Care; Cystic Fibrosis; Dimensions; Disease; Doctor of Philosophy; Environment; Faculty; Fellowship; Funding; Grant; Growth; Haemophilus Infections; Health; Health Sciences; Home environment; Hypersensitivity; Individual; Infection; Injury; Lung; Lung Inflammation; Medicine; Mentorship; Microbial Biofilms; Microbiology; Minnesota; Pathogenesis; Pediatrics; Physicians; Polyamines; Postdoctoral Fellow; Pseudomonas Infections; Public Health; Recruitment Activity; Research; Respiratory Tract Infections; Role; Scientist; Sleep; Students; Training; Translational Research; Universities; career; career development; catalyst; clinical care; cystic fibrosis patients; injury and repair; innovation; interest; lung injury; medical schools; meetings; member; microbial; pathogen; programs; ranpirnase; success

DESCRIPTION (provided by applicant): The University of Minnesota Pulmonary, Allergy, Critical Care & Sleep (PACCS) Division has been systematically recruiting additional physician scientists focused on lung injury and repair to join the tenure track faculty. Our faculty met and identified a significant gap in our faculty research interest profile in this area - respiratory infections. This area is not only of great importance as a public health issue in the US and worldwide, it is also an area with outstanding multi-disciplinary, collaborative scientific opportunities at the University of Minnesota. Within the PACCS Division, among our NIH-funded PIs, there are 7 faculty with expertise in lung inflammation and injury. In addition, there are three academically strong Centers and programs pertinent to our proposed recruit, providing a dynamic research environment to promote scientific growth and career development. The Center for Infectious Disease, Microbiology & Translational Research brings together faculty from the Medicine, Pediatrics and Microbiology Departments in interdisciplinary translational research on microbial pathogenesis. The Center for Lung Science and Health provides a home for faculty and students from across the Academic Health Center and larger University with interests related to lung health and disease. Finally, the University of Minnesota has an internationally renowned Cystic Fibrosis program. While this program is outstanding in clinical care and clinical trials activity, the basic research component is less strong. Thus a major recruitment target area of the PACCS Division is for a physician-scientist with research focused on respiratory infections, particularly with relevance to lung injury in Cystic Fibrosis. Our proposed P30 recruit, Bryan Williams MD, PhD is completing his fourth year of Pulmonary, Critical Care & CF fellowship at Vanderbilt University. His research focus is on host-pathogen interactions in respiratory infections, specifically exploring the role of a polyamine precursor, agmatine, that is important in Pseudomonas infections and in biofilm formation. He obtained his Microbiology PhD under the mentorship of Dr. Arnie Smith studying Hemophilus infections and his post-doctoral fellowship research has been supervised by Dr. Timothy Blackwell. Dr Williams' research relates directly to his clinical interest in CF-related lung dise disease, enabling convergence of his research and clinical program. The recruitment of Bryan Willliams MD, PhD will add the new dimension of expertise in respiratory infections to the PACCS Divisional research It will greatly augment basic research in the Cystic Fibrosis Center program and will provide a research bridge between the Center for Lung Science and Health and the Center for Infectious Disease, Microbiology Translational Research. Dr Williams's research brings an innovative approach to understanding and decreasing Pseudomonas infection in CF patients.

描述(由申请人提供)：明尼苏达大学肺、过敏、重症监护和睡眠(PACCS)分部一直在系统地招募更多专注于肺损伤和修复的内科科学家加入终身教职。我们的教员会面并确定了我们教员在这一领域--呼吸道感染--的研究兴趣方面的一个重大差距。这一领域不仅对美国和全世界的公共卫生问题非常重要，而且在明尼苏达大学也是一个拥有杰出的多学科、协作科学机会的领域。在PACCS部门，在我们NIH资助的PIs中，有7名教员拥有肺部炎症和损伤方面的专业知识。此外，我们有三个学术实力雄厚的中心和项目与我们建议的招聘相关，提供了一个充满活力的研究环境，以促进科学成长和职业发展。传染病、微生物学和翻译研究中心汇集了医学、儿科和微生物学系的教员，对微生物的发病机制进行跨学科的翻译研究。肺科学与健康中心为学术健康中心和更大的大学中对肺部健康和疾病感兴趣的教职员工和学生提供了一个家。最后，明尼苏达大学有一个国际知名的囊性纤维化项目。虽然这一计划在临床护理和临床试验活动中表现突出，但基础研究部分不那么强大。因此，PACCS司的主要招聘目标领域是一名内科科学家，其研究重点是呼吸道感染，特别是与囊性纤维化的肺损伤相关的研究。我们推荐的P30新人，布莱恩·威廉姆斯医学博士，即将完成他在范德比尔特大学的肺、重症护理和循环研究的第四个年头。他的研究重点是呼吸道感染中宿主与病原体的相互作用，特别是探索多胺前体--胍丁胺在假单胞菌感染和生物被膜形成中的重要作用。他在Arnie Smith博士的指导下获得了微生物学博士学位，研究嗜血杆菌感染，他的博士后研究一直由Timothy Blackwell博士指导。威廉姆斯博士的研究直接关系到他对CF相关肺病的临床兴趣，使他的研究和临床计划得以融合。 Bryan Willliams博士的招聘将为PACCS部门的研究增加呼吸道感染专业知识的新维度。它将极大地加强囊性纤维化中心计划的基础研究，并将在肺科学与健康中心和传染病微生物学翻译研究中心之间建立研究桥梁。威廉姆斯博士的研究为了解和减少CF患者的假单胞菌感染提供了一种创新的方法。