Supporting New Faculty Recruitment Through BioMedical Research Core Center

描述（由申请人提供）：明尼苏达大学肺、过敏、重症监护和睡眠（PACCS）部门正在系统地招募更多专注于肺损伤和修复的内科科学家加入终身教职员工。我们的教师会面并确定了我们的教师研究兴趣在这一领域的重大差距-呼吸道感染。这一领域不仅是美国和世界范围内非常重要的公共卫生问题，而且在明尼苏达大学也是一个具有杰出的多学科合作科学机会的领域。在PACCS部门，在美国国立卫生研究院资助的pi中，有7名教师在肺部炎症和损伤方面具有专业知识。此外，有三个学术实力雄厚的中心和项目与我们建议的招聘相关，提供一个充满活力的研究环境，以促进科学成长和职业发展。传染病、微生物学和转化研究中心汇集了医学、儿科和微生物学系的教师，进行微生物发病机制的跨学科转化研究。肺科学与健康中心为来自学术健康中心和大型大学的教师和学生提供了一个与肺部健康和疾病相关的兴趣的家。最后，明尼苏达大学有一个国际知名的囊性纤维化项目。虽然该项目在临床护理和临床试验活动方面表现突出，但基础研究部分不太强大。因此，PACCS部门的主要招聘目标领域是研究呼吸道感染，特别是与囊性纤维化肺损伤相关的内科科学家。我们推荐的P30新兵Bryan Williams医学博士正在范德比尔特大学完成他第四年的肺部，重症监护和CF奖学金。他的研究重点是呼吸道感染中的宿主-病原体相互作用，特别是探索多胺前体agmatine的作用，这在假单胞菌感染和生物膜形成中很重要。他在Arnie Smith博士的指导下获得微生物学博士学位，研究血友病感染，他的博士后研究由Timothy Blackwell博士监督。Williams博士的研究与他对cf相关肺部疾病的临床兴趣直接相关，使他的研究和临床项目得以融合。

DESCRIPTION (provided by applicant): The University of Minnesota Pulmonary, Allergy, Critical Care & Sleep (PACCS) Division has been systematically recruiting additional physician scientists focused on lung injury and repair to join the tenure track faculty. Our faculty met and identified a significant gap in our faculty research interest profile in this area - respiratory infections. This area is not only of great importance as a public health issue in the US and worldwide, it is also an area with outstanding multi-disciplinary, collaborative scientific opportunities at the University of Minnesota. Within the PACCS Division, among our NIH-funded PIs, there are 7 faculty with expertise in lung inflammation and injury. In addition, there are three academically strong Centers and programs pertinent to our proposed recruit, providing a dynamic research environment to promote scientific growth and career development. The Center for Infectious Disease, Microbiology & Translational Research brings together faculty from the Medicine, Pediatrics and Microbiology Departments in interdisciplinary translational research on microbial pathogenesis. The Center for Lung Science and Health provides a home for faculty and students from across the Academic Health Center and larger University with interests related to lung health and disease. Finally, the University of Minnesota has an internationally renowned Cystic Fibrosis program. While this program is outstanding in clinical care and clinical trials activity, the basic research component is less strong. Thus a major recruitment target area of the PACCS Division is for a physician-scientist with research focused on respiratory infections, particularly with relevance to lung injury in Cystic Fibrosis. Our proposed P30 recruit, Bryan Williams MD, PhD is completing his fourth year of Pulmonary, Critical Care & CF fellowship at Vanderbilt University. His research focus is on host-pathogen interactions in respiratory infections, specifically exploring the role of a polyamine precursor, agmatine, that is important in Pseudomonas infections and in biofilm formation. He obtained his Microbiology PhD under the mentorship of Dr. Arnie Smith studying Hemophilus infections and his post-doctoral fellowship research has been supervised by Dr. Timothy Blackwell. Dr Williams' research relates directly to his clinical interest in CF-related lung dise disease, enabling convergence of his research and clinical program. The recruitment of Bryan Willliams MD, PhD will add the new dimension of expertise in respiratory infections to the PACCS Divisional research It will greatly augment basic research in the Cystic Fibrosis Center program and will provide a research bridge between the Center for Lung Science and Health and the Center for Infectious Disease, Microbiology Translational Research. Dr Williams's research brings an innovative approach to understanding and decreasing Pseudomonas infection in CF patients.