Implantable Microsystems for Human Neuroprosthesis

用于人体神经假体的植入式微系统

• 批准号: 7849598
• 负责人: JOHN P DONOGHUE
• 金额: $ 131.47万
• 依托单位: BROWN UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-06-01 至 2012-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7849598
• 关键词: Abdomen; Achievement; Algorithms; Animal Experimentation; Animal Model; Animal Testing; Animals; Applications Grants; Architecture; Arts; Bionics; Brain; Calibration; Chest; Clinical; Clinical Trials; Communication; Complex; Coupled; Cybernetics; Data; Development; Devices; Diagnostic; Electrodes; Engineering; FPS-FES Oncogene; Feedback; Fiber; Fiber Optics; Figs - dietary; Film; Future; General Hospitals; Goals; Grant; Head; Human; Human Development; Implant; Learning; Light; Limb structure; Link; Massachusetts; Measurement; Measures; Microelectrodes; Miniaturization; Monitor; Monkeys; Motor Cortex; Movement; Muscle; Nerve; Nervous system structure; Neurology; Neurons; Neurosciences; Operative Surgical Procedures; Output; Pacemakers; Paralysed; Pathway interactions; Patients; Pattern; Performance; Persons; Polymers; Preclinical Testing; Principal Investigator; Process; Prosthesis; Protocols documentation; Quadriplegia; Real-Time Systems; Regulatory Pathway; Research; Research Ethics Committees; Research Infrastructure; Research Personnel; Role; Running; Safety; Scheme; Secure; Self-Help Devices; Signal Transduction; Source; Speed; Spinal Cord; Staging; Stream; System; Technology; Telemetry; Testing; Tissues; Toxicology; Universities; Validation; Vision; Wireless Technology; base; biomaterial compatibility; commercialization; computer science; computerized data processing; data exchange; design; experience; flexibility; implantation; in vivo; meetings; microsystems; miniaturize; neural prosthesis; neuroprosthesis; neurosurgery; neurotechnology; novel; operation; optical fiber; pilot trial; pre-clinical; programs; prototype; relating to nervous system; response; restoration; seal; sensor; skills; spatiotemporal; subcutaneous; transmission process

DESCRIPTION (provided by applicant): This BRP grant application describes a pioneering, integrated lightweight neuromotor prosthetic microsystem (NMP) for paralyzed humans: NMPs use neural activity as a direct output to machines that run assistive devices. To meet this goal we have assembled an interdisciplinary team that combines leaders in neuroscience (Donoghue) and engineering (Nurmikko), with support from computer science (Black) at Brown University and neurology/neurosurgery at Brown and at Massachusetts General Hospital (Hochberg); experts in NMP design, development, manufacturing and commercialization from Cybernetics, Inc. (CKI), a neurotechnology company; and experts in neural prosthesis development and human application at the Cleveland FES center/Case Western University (H. Peckham/R. Kirsch). We will develop an integrated and implantable microelectronic neurosensor system that features on-chip signal processing and wide bandwidth transcutaneous wireless transmission capabilities. The high performance microsystem incorporates cutting-edge ultralow power microelectronics and is designed to be technologically flexible and modular, to enable scaling to increasingly complex neural signal extraction and manipulation. Its components imbed adaptive processors for automated calibration and set-up which exploit neural decoding algorithms, currently being developed at Brown, to provide a stable, multipurpose output signal. The microsystem implant will be first tested in animal models (motor cortex of monkeys) to establish efficacy, biocompatibility and biostability. We will input learning acquired from ongoing and future human trial patients with the present percutaneous cabling system to establish principles of human NMP operation for adapting the implantable microsystem design, the role of learning in NMP use, and the limits of human NMP control. We will pursue the federal regulatory pathways to gain approval for the NMP microsystem while developing the assistive technology for human patients. The end goal of this BRP grant is to achieve the implantation and testing of the new microsystem chronically in a human patient. t ' The ultimate vision and guiding light for this BRP proposal is to develop the technological infrastructure to achieve a longer term goal, namely system is the restoration of semi-autonomous, closed-loop, distributed- feedback control of a limb that has lost spinal cord connection to the motor cortex.

描述（由申请人提供）：此 BRP 拨款申请描述了一种用于瘫痪人类的开创性集成轻型神经运动假肢微系统 (NMP)：NMP 使用神经活动作为运行辅助设备的机器的直接输出。为了实现这一目标，我们组建了一个跨学科团队，由神经科学 (Donoghue) 和工程学 (Nurmikko) 的领导者组成，并得到布朗大学计算机科学 (Black) 以及布朗大学和马萨诸塞州总医院 (Hochberg) 神经病学/神经外科 (Hochberg) 的支持；来自神经技术公司 Cyber​​netics, Inc. (CKI) 的 NMP 设计、开发、制造和商业化专家；克利夫兰 FES 中心/凯斯西储大学 (H. Peckham/R. Kirsch) 的神经假体开发和人体应用专家。我们将开发一种集成的、可植入的微电子神经传感器系统，具有片上信号处理和宽带宽经皮无线传输功能。该高性能微系统采用了尖端的超低功耗微电子技术，其设计具有技术灵活性和模块化特点，能够扩展到日益复杂的神经信号提取和操作。其组件嵌入了用于自动校准和设置的自适应处理器，该处理器利用布朗目前正在开发的神经解码算法来提供稳定的多用途输出信号。该微系统植入物将首先在动物模型（猴子运动皮层）中进行测试，以确定功效、生物相容性和生物稳定性。我们将使用现有的经皮布线系统输入从正在进行的和未来的人体试验患者获得的学习成果，以建立人体 NMP 操作的原则，以适应植入式微系统设计、学习在 NMP 使用中的作用以及人体 NMP 控制的限制。我们将寻求联邦监管途径来获得 NMP 微系统的批准，同时为人类患者开发辅助技术。 BRP 资助的最终目标是实现新微系统在人类患者体内的长期植入和测试。该 BRP 提案的最终愿景和指导思想是开发技术基础设施以实现长期目标，即系统恢复对失去脊髓与运动皮层连接的肢体的半自主、闭环、分布式反馈控制。