权益分类	功能权益	普通用户	{{item.name}}会员
{{category.name}}	{{benefitItem.name}}

Implantable Microsystems for Human Neuroprosthesis

用于人体神经假体的植入式微系统

基本信息

批准号：
8116598
负责人：
JOHN P DONOGHUE
金额：
$ 130.04万
依托单位：
BROWN UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2007
资助国家：
美国
起止时间：
2007-06-01 至 2014-05-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8116598
关键词：
Abdomen Achievement Algorithms Animal Experimentation Animal Model Animal Testing Animals Applications Grants Architecture Bionics Brain Calibration Chest Clinical Clinical Trials Communication Complex Coupled Cybernetics Data Development Devices Diagnostic Electrodes Engineering FPS-FES Oncogene Feedback Fiber Fiber Optics Figs - dietary Film Future General Hospitals Goals Grant Head Human Human Development Implant Institutional Review Boards Learning Light Limb structure Link Massachusetts Measurement Measures Microelectrodes Miniaturization Monitor Monkeys Motor Cortex Movement Muscle Nerve Nervous system structure Neurology Neurons Neurosciences Operative Surgical Procedures Output Pacemakers Paralysed Pathway interactions Patients Pattern Performance Persons Polymers Preclinical Testing Principal Investigator Process Prosthesis Protocols documentation Quadriplegia Real-Time Systems Regulatory Pathway Research Research Infrastructure Research Personnel Role Running Safety Scheme Secure Self-Help Devices Signal Transduction Source Speed Spinal Cord Staging Stream System Technology Telemetry Testing Tissues Toxicology Universities Validation Vision Wireless Technology base biomaterial compatibility commercialization computer science computerized data processing data exchange design experience flexibility implantation in vivo meetings microsystems miniaturize neural prosthesis neuroprosthesis neurosurgery neurotechnology novel operation optical fiber pilot trial pre-clinical programs prototype relating to nervous system response restoration seal sensor skills spatiotemporal subcutaneous transmission process

项目摘要

DESCRIPTION (provided by applicant): This BRP grant application describes a pioneering, integrated lightweight neuromotor prosthetic microsystem (NMP) for paralyzed humans: NMPs use neural activity as a direct output to machines that run assistive devices. To meet this goal we have assembled an interdisciplinary team that combines leaders in neuroscience (Donoghue) and engineering (Nurmikko), with support from computer science (Black) at Brown University and neurology/neurosurgery at Brown and at Massachusetts General Hospital (Hochberg); experts in NMP design, development, manufacturing and commercialization from Cybernetics, Inc. (CKI), a neurotechnology company; and experts in neural prosthesis development and human application at the Cleveland FES center/Case Western University (H. Peckham/R. Kirsch). We will develop an integrated and implantable microelectronic neurosensor system that features on-chip signal processing and wide bandwidth transcutaneous wireless transmission capabilities. The high performance microsystem incorporates cutting-edge ultralow power microelectronics and is designed to be technologically flexible and modular, to enable scaling to increasingly complex neural signal extraction and manipulation. Its components imbed adaptive processors for automated calibration and set-up which exploit neural decoding algorithms, currently being developed at Brown, to provide a stable, multipurpose output signal. The microsystem implant will be first tested in animal models (motor cortex of monkeys) to establish efficacy, biocompatibility and biostability. We will input learning acquired from ongoing and future human trial patients with the present percutaneous cabling system to establish principles of human NMP operation for adapting the implantable microsystem design, the role of learning in NMP use, and the limits of human NMP control. We will pursue the federal regulatory pathways to gain approval for the NMP microsystem while developing the assistive technology for human patients. The end goal of this BRP grant is to achieve the implantation and testing of the new microsystem chronically in a human patient. t ' The ultimate vision and guiding light for this BRP proposal is to develop the technological infrastructure to achieve a longer term goal, namely system is the restoration of semi-autonomous, closed-loop, distributed- feedback control of a limb that has lost spinal cord connection to the motor cortex.

描述（由申请人提供）：此BRP资助申请描述了一种用于瘫痪人类的开创性集成轻型神经运动假肢微系统（NMP）：NMP使用神经活动作为运行辅助设备的机器的直接输出。为了实现这一目标，我们组建了一个跨学科团队，该团队结合了神经科学（Donoghue）和工程（Nurmikko）的领导者，并得到了布朗大学计算机科学（Black）和布朗大学神经病学/神经外科以及马萨诸塞州综合医院（Hochberg）的支持;来自Cybernetics，Inc.的NMP设计、开发、制造和商业化专家。(CKI)一家神经技术公司;以及克利夫兰FES中心/凯斯西大学（H。佩卡姆河Kirsch）。我们将开发一个集成的和可植入的微电子神经传感器系统，具有片上信号处理和宽带经皮无线传输能力。高性能微系统采用了先进的超低功耗微电子技术，设计具有技术灵活性和模块化，可扩展到日益复杂的神经信号提取和操作。它的组件嵌入自适应处理器，用于自动校准和设置，利用布朗目前正在开发的神经解码算法，提供稳定的多用途输出信号。微系统植入物将首先在动物模型（猴子的运动皮质）中进行测试，以确定有效性、生物相容性和生物稳定性。我们将输入从正在进行的和未来的人体试验患者与目前的经皮电缆系统获得的学习，以建立人类NMP操作的原则，以适应植入式微系统设计，学习在NMP使用中的作用，以及人类NMP控制的局限性。我们将寻求联邦监管途径，以获得对NMP微系统的批准，同时为人类患者开发辅助技术。这项BRP资助的最终目标是实现新的微系统在人类患者中的长期植入和测试。该BRP提案的最终愿景和指路明灯是开发技术基础设施以实现更长期的目标，即系统是对已经失去脊髓连接到运动皮层的肢体的半自主、闭环、分布反馈控制的恢复。

项目成果

期刊论文数量（12）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Integrated device for optical stimulation and spatiotemporal electrical recording of neural activity in light-sensitized brain tissue.

DOI：
10.1088/1741-2560/6/5/055007
发表时间：
2009-10
期刊：
Journal of neural engineering
影响因子：
4
作者：
Zhang J;Laiwalla F;Kim JA;Urabe H;Van Wagenen R;Song YK;Connors BW;Zhang F;Deisseroth K;Nurmikko AV
通讯作者：
Nurmikko AV

Active microelectronic neurosensor arrays for implantable brain communication interfaces.

DOI：
10.1109/tnsre.2009.2024310
发表时间：
2009-08
期刊：
IEEE transactions on neural systems and rehabilitation engineering : a publication of the IEEE Engineering in Medicine and Biology Society
影响因子：
0
作者：
Song YK;Borton DA;Park S;Patterson WR;Bull CW;Laiwalla F;Mislow J;Simeral JD;Donoghue JP;Nurmikko AV
通讯作者：
Nurmikko AV

Polymeric packaging for fully implantable wireless neural microsensors.

用于完全植入式无线神经微传感器的聚合物封装。