10th International Symposium on Cytochrome P450 Biodiversity and Biotechnology

第十届细胞色素P450生物多样性与生物技术国际研讨会

• 批准号: 8008659
• 负责人: JOHN J STEGEMAN
• 金额: $ 0.5万
• 依托单位: WOODS HOLE OCEANOGRAPHIC INSTITUTION
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-09-01 至 2011-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8008659
• 关键词: Address; Animal Model; Area; Bacteria; Biodiversity; Biomedical Engineering; Bioremediations; Biotechnology; Catalytic Domain; Chemicals; Coupled; Cytochrome P450; Drug Metabolic Detoxication; Engineering; Enzyme Gene; Enzymes; Evolution; Exposure to; Fostering; Funding; Gene Proteins; Genes; Goals; Insecta; International; Knowledge; Pathway interactions; Pharmaceutical Preparations; Plants; Postdoctoral Fellow; Process; Research; Risk Assessment; Role; Scientist; Structural Protein; Structure; Students; System; Toxicology; Training; Xenobiotic Metabolism; Xenobiotics; Zebrafish; graduate student; insight; meetings; microbial; novel; plant fungi; public health relevance; remediation; response; symposium

DESCRIPTION (provided by applicant): This application is for funding for graduate students and post-docs to attend the 10th International Symposium on Cytochrome P450 Biodiversity and Biotechnology. This meeting deals with aspects of evolution, structure, function, and application of cytochrome P450 genes and enzymes, emphasizing CYPs in bacteria, fungi, plants, and non-mammalian animal models. The rapidly increasing number of crystal structures coupled with the huge number of CYP sequences (now in excess of 12,000), makes it possible to look at structural evolution from the sequence as well as tertiary structural perspective, with a greater understanding than possible before. Protein structural studies consider function of CYP enzymes in synthesis of bioactive compounds, and in the metabolism of xenobiotic chemicals and endogenous compounds. This meeting also includes engineering of CYP genes, to generate enzymes with novel functions as well as to gain insights into catalytic mechanisms with xenobiotic and endogenous substrates. The application of information and engineered systems in bioremediation, risk assessment and ecological processes is also addressed. The meeting includes responses of each taxonomic group to xenobiotic exposure, and the role of CYP genes and proteins in adaptation and response to that exposure. This will include important non-mammalian animal models used in toxicology, such as zebrafish and others. PUBLIC HEALTH RELEVANCE: This application is for funds to provide support for graduate students and post-doctoral students to participate in the 10th International Symposium on Cytochrome P450 Biodiversity and Biotechnology. This meeting will provide a critical forum for discussions on cytochrome P450 (CYP) genes and proteins a wide range of microbial, fungal, insect, plant and some vertebrate species. The overall goal of this 10th symposium is to foster a synthesis of understanding of cytochrome P450 (CYP) structural and functional evolution, and new directions in application this knowledge in environmental assessment, remediation, and synthesis of new potential drugs. The goals will be accomplished by providing a mechanism for garnering new ideas and input from outstanding scientists that represent a very diverse background of expertise and training, at the forefront of research on CYP genes. Sessions in this meeting include evolutionary and mechanistic comparisons among available P450 structures, functional comparisons among microbial, insect and plant P450s in synthetic and detoxification pathways, as well as bioengineering of P450 catalytic sites for technological and environmental applications. Participation of graduate students and post-doctoral students is important for a continued vitality in this important area of research.

描述（由申请人提供）：本申请是为研究生和博士后参加第10届细胞色素P450生物多样性和生物技术国际研讨会提供资金。本次会议涉及细胞色素P450基因和酶的进化，结构，功能和应用方面，强调细菌，真菌，植物和非哺乳动物模型中的CYP。晶体结构数量的迅速增加，加上大量的层序（现在超过12，000个），使得有可能从层序和三级结构的角度来看待结构演化，比以前有更好的理解。蛋白质结构的研究考虑了生物活性化合物的合成中，以及外源性化学物质和内源性化合物的代谢中的酶的功能。本次会议还包括工程的生物合成基因，以产生新的功能酶，以及深入了解催化机制与外源性和内源性底物。信息和工程系统在生物修复，风险评估和生态过程中的应用也得到了解决。会议包括每个分类群体对外源性暴露的反应，以及生物素基因和蛋白质在适应和对这种暴露的反应中的作用。这将包括毒理学中使用的重要非哺乳动物模型，如斑马鱼等。 公共卫生关系：本申请为资助研究生和博士后参加第十届细胞色素P450生物多样性和生物技术国际研讨会提供资金。这次会议将提供一个重要的论坛，讨论细胞色素P450（CYP450）基因和蛋白质的广泛的微生物，真菌，昆虫，植物和一些脊椎动物物种。第10届研讨会的总体目标是促进对细胞色素P450（CYP450）结构和功能进化的综合理解，以及将这些知识应用于环境评估，修复和合成新的潜在药物的新方向。这些目标将通过提供一个机制来实现，以便从代表着非常多样化的专业知识和培训背景的杰出科学家那里获得新的想法和投入，这些科学家处于基因研究的最前沿。会议内容包括现有P450结构之间的进化和机制比较，微生物、昆虫和植物P450在合成和解毒途径中的功能比较，以及P450催化位点在技术和环境应用中的生物工程。研究生和博士后学生的参与对于这一重要研究领域的持续活力至关重要。