WHCOHH: Harmful algal bloom dynamics and epigenetic mechanism of toxin action

WHCOHH：有害藻华动态和毒素作用的表观遗传机制

• 批准号: 9116202
• 负责人: JOHN J STEGEMAN
• 金额: $ 44.3万
• 依托单位: WOODS HOLE OCEANOGRAPHIC INSTITUTION
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-09-24 至 2018-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9116202
• 关键词: Address; Adult; Advisory Committees; Affect; Archives; Area; Biological Models; Communication; Community Health Education; Community Outreach; Data; Development; Dinophyceae; Ensure; Epigenetic Process; Evaluation; Exposure to; Fostering; Goals; Grant; Information Dissemination; Life; Link; Maine; Marine Toxins; Mission; Modeling; Monitor; National Institute of Environmental Health Sciences; Neurotoxins; Organism; Performance; Physiological; Policies; Population Dynamics; Process; Production; Public Health; Reporting; Research; Research Personnel; Resources; Risk; Sampling; Societies; Structure; System; Technology; Toxin; harmful algal blooms; improved; insight; meetings; member; novel; predictive modeling; programs; public health relevance; toxicant; web page

DESCRIPTION (provided by applicant) This Program Project application will employ novel remote sampling technologies to achieve new insights into the population dynamics of known and emerging HAB threats, and to address critical mechanisms of toxin action, linking developmental exposures to adult consequences. The Center will be overseen and guided by the Director and Deputy Director. The aims of the Administrative Core are to: 1) Facilitate communication, planning, integration and interaction among Center members, so that the goals and scientific objectives of the Center are achieved. 2) Provide and maintain an administrative structure to oversee and monitor the financial aspects of the Center, including grants management. 3) Establish a structure that will support effective communication and planning with contribution from all Center investigators, through an Internal Advisory Committee. 4) Establish an External Advisory Committee, which will review the Center programs and advise the Director and Deputy Director. 5) Implement evaluation mechanisms, utilizing both Internal and External Advisory Committees. 6) Establish and maintain public and private web pages for the dissemination of information and for data transfer and communication 7) Pursue interactions between the WHCOHH and other OHH Centers, as well as with other EHS Centers, in order to expand the reach and impact of the Center, and potentially to engage collaborators on research issues relevant to the Center mission and themes. 8) Encourage the involvement of Center investigators in community outreach and education efforts. 9) Prepare and deliver the required reports to the NSF and the NIEHS. 10) Organize COHH meetings as required. 11) Ensure compliance with data submission and archiving policies.

描述（由申请人提供） 该计划项目应用将采用新型远程采样技术，以实现对已知和新出现的有害藻华威胁的种群动态的新见解，并解决毒素作用的关键机制，将发育暴露与成人后果联系起来。中心将由主任和副主任监督和指导。行政核心的目标是：1）促进中心成员之间的沟通，规划，整合和互动，从而实现中心的目标和科学目标。2)提供和维持一个行政结构，以监督和监测中心的财务方面，包括赠款管理。3)通过内部咨询委员会建立一个结构，支持所有中心研究者的有效沟通和规划。 4)设立外部咨询委员会，负责审查中心的方案，并向主任和副主任提出建议。 5)利用内部和外部咨询委员会实施评价机制。 6)建立和维护公共和私人网页，用于信息传播以及数据传输和交流7）寻求WHCOHH与其他OHH中心以及其他EHS中心之间的互动，以扩大中心的覆盖范围和影响，并可能就与中心使命和主题相关的研究问题与合作者进行合作。 8)鼓励中心调查人员参与社区外展和教育工作。 9)准备并向NSF和NIEHS提交所需的报告。 10)根据需要组织COHH会议。11)确保遵守数据提交和归档政策。

项目成果

Metabolic arsenal of giant viruses: Host hijack or self-use?

• DOI: 10.7554/elife.78674
• 发表时间: 2022-07-08
• 期刊: ELIFE
• 影响因子: 7.7
• 作者: Belhaouari, Djamal Brahim;De Souza, Gabriel Augusto Pires;Lamb, David C.;Kelly, Steven L.;Goldstone, Jared, V;Stegeman, John J.;Colson, Philippe;La Scola, Bernard;Aherfi, Sarah
• 通讯作者: Aherfi, Sarah

Characterization of a Virally Encoded Flavodoxin That Can Drive Bacterial Cytochrome P450 Monooxygenase Activity.

• DOI: 10.3390/biom12081107
• 发表时间: 2022-08-11
• 期刊: Biomolecules
• 影响因子: 5.5

Differential cellular responses associated with oxidative stress and cell fate decision under nitrate and phosphate limitations in Thalassiosira pseudonana: Comparative proteomics.

假微型海链藻硝酸盐和磷酸盐限制下与氧化应激和细胞命运决定相关的差异细胞反应：比较蛋白质组学

• DOI: 10.1371/journal.pone.0184849
• 发表时间: 2017
• 期刊: PloS one
• 影响因子: 3.7
• 作者: Lin Q;Liang JR;Huang QQ;Luo CS;Anderson DM;Bowler C;Chen CP;Li XS;Gao YH
• 通讯作者: Gao YH

Developmental exposure to low concentrations of two brominated flame retardants, BDE-47 and BDE-99, causes life-long behavioral alterations in zebrafish.

• DOI: 10.1016/j.neuro.2017.09.007
• 发表时间: 2018-05
• 期刊: Neurotoxicology
• 影响因子: 3.4
• 作者: Glazer L;Wells CN;Drastal M;Odamah KA;Galat RE;Behl M;Levin ED
• 通讯作者: Levin ED

The effect of the toxic dinoflagellate Alexandrium fundyense on the fitness of the calanoid copepod Calanus finmarchicus.

有毒甲藻亚历山大藻对桡足类 Calanus finmarchicus 适应性的影响。

• DOI: 10.1016/j.hal.2015.11.003
• 发表时间: 2016
• 期刊: Harmful algae
• 影响因子: 6.6
• 作者: Roncalli,Vittoria;Turner,JeffersonT;Kulis,David;Anderson,DonaldM;Lenz,PetraH
• 通讯作者: Lenz,PetraH