2010 Biopolymers Gordon Research Conference

描述（由申请人提供）：申请资金用于2010年生物聚合物戈登研究会议的部分支持。这个会议有着悠久而杰出的历史，它服务于科学界，专注于理解生物聚合物（蛋白质、RNA、DNA）的基本物理化学性质，包括它们的结构、折叠、动力学、稳定性和相互作用。2010年生物聚合物GRC特别关注支持少数民族和妇女的参与。会议的主要目标是提高我们对生物聚合物基本特性的理解，以及这些特性与其生物学功能之间的关系。本次会议的具体目的是将生物聚合物领域的领导者与初级科学家、博士后和学生聚集在一起，在为期五天的会议中讨论当前阐明生物聚合物及其复合物的结构、功能和折叠的方法。该提案的意义在于生物聚合物戈登会议在促进应用广泛技术来理解许多不同系统的科学家之间的跨学科互动方面发挥的独特作用。这种类型的定期跨学科会议通过促进解决问题的不同方法的整合，不可避免地支持科学的进步。最重要的是，戈登研究会议的形式，其中大量的时间分配给非正式和正式的讨论，是理想的促进互动，这是跨学科科学的关键先驱。此外，生物聚合物GRC通过推进对生物大分子基本特性的理解，将直接有利于不同领域的生物医学研究。在为2010年会议选择主题和发言人时，征求了科学界成员的意见。组织者还采纳了针对2008年计划提出的建议。除了主题会议外，2010年的日程安排还包括以下常规会议：RNA的结构、折叠与动力学作用于核酸的分子机器；3. 结合、变构和动力学；4. 从出生到死亡的蛋白质；5. 设计生物聚合物；6. 膜蛋白：结构、折叠与功能7. 折叠和展开，有序和无序，以及8。淀粉样蛋白（错误折叠致死）。

DESCRIPTION (provided by applicant): Funds are requested for partial support of the 2010 Biopolymers Gordon Research Conference. This conference has a long and distinguished history of serving the segment of the scientific community that is focused on understanding fundamental physical-chemical properties of biopolymers (proteins, RNA, DNA), including their structures, folding, dynamics, stability, and interactions. The 2010 Biopolymers GRC is particularly interested in supporting the participation of minorities and women. The broad goals of the conference are to improve our understanding of the fundamental properties of biopolymers and the relationship of these properties to their biological function. The specific aims of this meeting are to assemble leaders in the biopolymers field with junior scientists, postdocs and students in a five-day conference to discuss current approaches to elucidating the structures, function and folding of biopolymers and their complexes. The significance of the proposal is the unique role that the Biopolymers Gordon Conference plays in fostering interdisciplinary interactions among scientists who apply a breadth of techniques to understanding a number of distinct systems. Regular interdisciplinary meetings of this type inevitably support advances in science by promoting integration of distinct approaches to solving problems. Most importantly, the format of the Gordon Research Conference, in which much time is allotted to informal and formal discussion, is ideal for fostering the interactions that are critical precursors to interdisciplinary science. Furthermore, the Biopolymers GRC, by advancing understanding of the fundamental properties of biological macromolecules will directly benefit biomedical research across diverse fields. In choosing topics and speakers for the 2010 meeting, input was sought from members of science community. The organizers have also incorporated suggestions offered in response to the 2008 program. In addition to a keynote session, the 2010 schedule includes the following regular sessions: 1. RNA structure, folding and dynamics 2. Molecular Machines Acting on Nucleic Acids; 3. Binding, Allostery and Dynamics; 4. Proteins from Birth to Death; 5. Biopolymers by Design; 6. Membrane Proteins: Structure, Folding and Function; 7. Folding and Unfolding, Order and Disorder, and 8. Amyloid (Death by Misfolding). PUBLIC HEALTH RELEVANCE: Biopolymers (proteins, RNA, DNA) are central to biological processes including signal transduction, metabolism and gene expression. Since defects in biopolymers are implicated in many human diseases, they are drug targets and are increasingly utilized as therapeutic agents themselves. The 2010 Biopolymers Gordon Research Conference will feature discussion of recent advances in understanding the structure, stability and dynamics of biopolymers as well as engineering of biopolymers for new function.