2010 Cold Spring Harbor Laboratory Symposium On Quantitative Biology: Nuclear Org

描述（由申请人提供）：斯图尔特，大卫冷泉港实验室会议第75届定量生物学核组织和功能年度研讨会2010年6月2日至7日冷泉港定量生物学研讨会每年6月初在纽约冷泉港的冷泉港实验室举行。他们汇集了来自世界各地的大约300-400名科学家，展示和评估生物研究快速发展领域的新数据和想法。每年选定的一个专题似乎处于需要进行全面和深入审查的阶段。研讨会总是寻求把研究工作者从国外，以及美国，以确保方案的广度和深度，并利用它们的具体贡献。他们还寻求为优秀的年轻科学家，包括研究生和博士后研究员，提供参与和与更资深的科学家交流的机会。研讨会还寻求妇女和少数民族科学家的参与。研讨会汇集了使用各种方法的科学家，例如，遗传学、生物化学、分子生物学、细胞生物学和结构研究，以分析所讨论领域的问题。领先的链档案使视频记录的会谈立即提供给那些谁参加了同事，而座谈会的会议记录由实验室出版，从而提供给更广泛的观众比科学家谁参加会议。在研讨会期间对主要科学家进行的深入访谈提供了当前研究状况的另一种快照。年度研讨会将继续计划，以进一步推动生物医学科学的进步。该提案要求为2010年期间提供支持，以涵盖第75届冷泉港研讨会，该研讨会将侧重于“核组织和功能”，并反映了对细胞核的描述性细胞生物学方法与对核过程的机制驱动方法之间的日益趋同，这些方法现在正在阐明过程之间的联系和动态，以更好地建立小区的主控制中心的结构和功能组织如何操作。特别是，本申请寻求联邦支持初级参与者，包括选定的研讨会研究员，积极介绍他们的最新工作在这个历史性的时刻，以及一些受邀发言人谁形成的核心会议。 公共卫生相关性：细胞核是细胞的运作总部，构成我们遗传物质的DNA和染色体都在那里。细胞核具有明确的外围或膜，包括蛋白质、核酸和小分子在内的物质必须通过这些外围或膜通过门状孔进出细胞核。越来越清楚的是，在细胞核内，一个复杂而动态的结构有助于决定基因何时以及如何打开和关闭。包括加速老化在内的人类疾病现在被理解为涉及这些结构或机制中的一些畸变。本次研讨会将讨论细胞核的动态组织和功能，以及我们对这些系统的理解如何有助于预防或治疗这些疾病。

DESCRIPTION (provided by applicant): Stewart, David Cold Spring Harbor Laboratory Conference 75th Annual Symposium on Quantitative Biology Nuclear Organization and Function June 2 - 7, 2010 The Cold Spring Harbor Symposia on Quantitative Biology are held yearly at the beginning of June at the Cold Spring Harbor Laboratory, Cold Spring Harbor, New York. They bring together approximately 300-400 scientists from all over the world to present and evaluate new data and ideas in rapidly moving areas of biological research. Each year, a topic is chosen that seems to be at a stage where general and intensive scrutiny and review is needed. The Symposia always seek to bring research workers from abroad, as well as the U.S., so as to ensure the wide scope and depth of the program and to take advantage of their specific contributions. They also seek to provide outstanding younger scientists, both graduate students and post-doctoral fellows, with an opportunity to participate and communicate with more senior scientists. The Symposia also seek to have participation from women and minority scientists. The Symposia bring together scientists who use a variety of approaches, e.g., genetics, biochemistry, molecular biology, cell biology, and structural studies, to analyze problems in the area under discussion. The Leading Strand archive makes video recordings of the talks immediately available to colleagues of those who attended, while the proceedings of the Symposia are published by the Laboratory and thus made available to a wider audience than the scientists who attend the meeting. In-depth interviews with leading scientists undertaken during the Symposium provide an alternative snapshot of the state of current research. The annual Symposia will continue to be planned to further the progress of advancements in biomedical science. This proposal request support for the period 2010 to cover the 75th Cold Spring Harbor Symposium which will focus on "Nuclear Organization and Function" and reflects the growing convergence between descriptive cell biological approaches to the nucleus and mechanism-driven approaches to nuclear processes that is now shedding light on the connections and dynamics between processes, to better establish how the structural and functional organization of the primary control center of the cell operates. In particular, this application seeks federal support for junior participants including selected Symposium Fellows to actively present their latest work at this historic occasion, as well as some of the invited speakers who form the core of the meeting. PUBLIC HEALTH RELEVANCE: The nucleus is the operational headquarters of the cell, where the DNA and chromosome that make up our genetic material are housed. The nucleus has a well defined periphery or membrane through which materials including proteins, nucleic acids and small molecules have to traffic into and out the nucleus through gate-like pores. It is becoming increasingly clear that inside the nucleus, a complicated and dynamic architecture helps to determines when and how genes are turned on and off. Human diseases including accelerated aging are now understood to involve aberrations in some of these structures or mechanisms. This Symposium will address the dynamic organization and function of the nucleus, and how advances in our understanding of these systems may help in preventing or treating these diseases.