2010 Cold Spring Harbor Laboratory Symposium On Quantitative Biology: Nuclear Org

2010年冷泉港实验室定量生物学研讨会：核组织

• 批准号: 7914886
• 负责人: DAVID J. STEWART
• 金额: $ 1万
• 依托单位: COLD SPRING HARBOR LABORATORY
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-04-01 至 2011-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7914886
• 关键词: Address; Aging; Architecture; Archives; Area; Biochemistry; Biological; Biology; Cell Nucleus; Cells; Cellular biology; Chromosomes; DNA; Data; Disease; Ensure; Genes; Genetic; Genetic Materials; Housing; Interview; Laboratories; Light; Membrane; Minority; Molecular Biology; New York; Nuclear; Nucleic Acids; Participant; Postdoctoral Fellow; Process; Proteins; Publishing; Request for Proposals; Research; Science; Scientist; Senior Scientist; Staging; Structure; System; Video Recording; Woman; Work; biological research; graduate student; human disease; meetings; prevent; programs; public health relevance; small molecule; symposium; trafficking

DESCRIPTION (provided by applicant): Stewart, David Cold Spring Harbor Laboratory Conference 75th Annual Symposium on Quantitative Biology Nuclear Organization and Function June 2 - 7, 2010 The Cold Spring Harbor Symposia on Quantitative Biology are held yearly at the beginning of June at the Cold Spring Harbor Laboratory, Cold Spring Harbor, New York. They bring together approximately 300-400 scientists from all over the world to present and evaluate new data and ideas in rapidly moving areas of biological research. Each year, a topic is chosen that seems to be at a stage where general and intensive scrutiny and review is needed. The Symposia always seek to bring research workers from abroad, as well as the U.S., so as to ensure the wide scope and depth of the program and to take advantage of their specific contributions. They also seek to provide outstanding younger scientists, both graduate students and post-doctoral fellows, with an opportunity to participate and communicate with more senior scientists. The Symposia also seek to have participation from women and minority scientists. The Symposia bring together scientists who use a variety of approaches, e.g., genetics, biochemistry, molecular biology, cell biology, and structural studies, to analyze problems in the area under discussion. The Leading Strand archive makes video recordings of the talks immediately available to colleagues of those who attended, while the proceedings of the Symposia are published by the Laboratory and thus made available to a wider audience than the scientists who attend the meeting. In-depth interviews with leading scientists undertaken during the Symposium provide an alternative snapshot of the state of current research. The annual Symposia will continue to be planned to further the progress of advancements in biomedical science. This proposal request support for the period 2010 to cover the 75th Cold Spring Harbor Symposium which will focus on "Nuclear Organization and Function" and reflects the growing convergence between descriptive cell biological approaches to the nucleus and mechanism-driven approaches to nuclear processes that is now shedding light on the connections and dynamics between processes, to better establish how the structural and functional organization of the primary control center of the cell operates. In particular, this application seeks federal support for junior participants including selected Symposium Fellows to actively present their latest work at this historic occasion, as well as some of the invited speakers who form the core of the meeting. PUBLIC HEALTH RELEVANCE: The nucleus is the operational headquarters of the cell, where the DNA and chromosome that make up our genetic material are housed. The nucleus has a well defined periphery or membrane through which materials including proteins, nucleic acids and small molecules have to traffic into and out the nucleus through gate-like pores. It is becoming increasingly clear that inside the nucleus, a complicated and dynamic architecture helps to determines when and how genes are turned on and off. Human diseases including accelerated aging are now understood to involve aberrations in some of these structures or mechanisms. This Symposium will address the dynamic organization and function of the nucleus, and how advances in our understanding of these systems may help in preventing or treating these diseases.

描述（由申请人提供）：Stewart， David冷泉港实验室会议第75届定量生物学核组织与功能年度研讨会2010年6月2 - 7日冷泉港定量生物学研讨会每年6月初在纽约冷泉港冷泉港实验室举行。他们汇集了来自世界各地的大约300-400名科学家，展示和评估快速发展的生物研究领域的新数据和想法。每年都会选择一个似乎处于需要全面和深入审查和审查阶段的主题。研讨会一直寻求从国外和美国引进研究工作者，以确保项目的广泛性和深度，并利用他们的具体贡献。他们还寻求为优秀的年轻科学家（包括研究生和博士后）提供参与和与更资深的科学家交流的机会。研讨会还寻求妇女和少数族裔科学家的参与。研讨会汇集了使用各种方法的科学家，例如遗传学，生物化学，分子生物学，细胞生物学和结构研究，来分析讨论领域的问题。Leading Strand档案馆将会议的视频记录立即提供给与会者的同事，而研讨会的会议记录则由实验室出版，从而提供给比参加会议的科学家更广泛的受众。在研讨会期间对主要科学家进行的深入访谈提供了当前研究状况的另一种快照。将继续计划年度专题讨论会，以进一步推动生物医学科学的进步。本提案要求在2010年期间支持第75届冷泉港研讨会，该研讨会将重点关注“核组织和功能”，并反映了描述细胞核的细胞生物学方法与机制驱动的核过程方法之间的日益融合，这些方法现在正在阐明过程之间的联系和动态。为了更好地确定细胞主要控制中心的结构和功能组织是如何运作的。特别地，本申请寻求联邦政府对年轻参与者的支持，包括选定的研讨会研究员，在这个历史性的时刻积极展示他们的最新作品，以及一些被邀请的演讲者，他们构成了会议的核心。