STRUCTURAL STUDY OF BACTERIAL TOXINS

细菌毒素的结构研究

• 批准号: 8170013
• 负责人: IRIMPAN I MATHEWS
• 金额: $ 0.34万
• 依托单位: STANFORD UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-05-01 至 2011-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8170013
• 关键词: Bacterial Toxins; Computer Retrieval of Information on Scientific Projects Database; Funding; Grant; Institution; Pharmaceutical Preparations; Research; Research Personnel; Resources; Safety; Source; Toxin; United States National Institutes of Health; Work; prevent

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Bacterial toxins cause various pathological effects. The current study proposes to investigate the effect of few known bacterial toxins. The primary aim is to develop potential drugs to treat or prevent toxin related illness. The preliminary studies have generated few potential targets and the structural study is aimed at understanding the mechanism. Due to safety concern, we will be working on genetically modified forms which are inactivated and nontoxic.

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 细菌毒素引起各种病理效应。目前的研究建议调查少数已知细菌毒素的影响。主要目的是开发潜在的药物来治疗或预防与毒素有关的疾病。初步研究产生了一些潜在的目标和结构研究的目的是了解机制。出于安全考虑，我们将致力于基因改造的形式，这是灭活和无毒。