STRUCTURAL STUDY OF HLA-DQ2 AND AN ASSOCIATED COMPLEX

HLA-DQ2 及相关复合物的结构研究

基本信息

  • 批准号:
    8362031
  • 负责人:
  • 金额:
    $ 0.38万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2011
  • 资助国家:
    美国
  • 起止时间:
    2011-03-01 至 2012-02-29
  • 项目状态:
    已结题

项目摘要

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. This study is aimed at understanding the mechanism of HLA-DQ2 interaction with other molecules. The human major histocompatibility complex (MHC), encoded on chromosome 6, is associated with susceptibility to many immunopathological diseases. One of the diseases with the strongest association with particular MHC alleles is celiac disease, for which there is also mechanistic insight into the basis for the human leukocyte antigen (HLA) association. Celiac disease is caused by an inappropriate intestinal immune response to wheat gluten (consisting of the gliadin and glutenin subcomponents) and the related proteins of rye and barley. Patients with celiac disease have gluten-reactive CD4+ T cells in their small intestinal mucosa, but healthy controls do not. Most patients with celiac disease carry the HLA-DQ2 variant DQ2.5, which is encoded by the DQA1*0501 and DQB1*0201 genes of the DR3-DQ2 haplotype. Most of the few remaining patients express HLA-DQ8. The gluten-reactive T cells of patients with celiac disease recognize a diverse set of gluten epitopes presented in context of DQ2.5 or DQ8 MHC molecules but not in the context of other MHC class II molecules expressed by the patients. 'Preferential' presentation of gluten peptides by the DQ2.5 and DQ8 molecules thus seems to explain the association of HLA with celiac disease.
这个子项目是利用这些资源的众多研究子项目之一

项目成果

期刊论文数量(0)
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会议论文数量(0)
专利数量(0)

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IRIMPAN I MATHEWS其他文献

IRIMPAN I MATHEWS的其他文献

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{{ truncateString('IRIMPAN I MATHEWS', 18)}}的其他基金

PREVENTING RADIATION DECAY IN PROTEIN CRYSTALS
防止蛋白质晶体的辐射衰变
  • 批准号:
    8362093
  • 财政年份:
    2011
  • 资助金额:
    $ 0.38万
  • 项目类别:
STRUCTURAL STUDY OF BACTERIAL TOXINS
细菌毒素的结构研究
  • 批准号:
    8362107
  • 财政年份:
    2011
  • 资助金额:
    $ 0.38万
  • 项目类别:
FUNCTIONAL STUDY OF ADP-GLUCOSE PYROPHOSPHORYLASE
ADP-葡萄糖焦磷酸酶的功能研究
  • 批准号:
    8362108
  • 财政年份:
    2011
  • 资助金额:
    $ 0.38万
  • 项目类别:
MECHANISTIC STUDY OF CLC CHLORIDE-TRANSPORT PROTEINS
CLC 氯离子转运蛋白的机理研究
  • 批准号:
    8170014
  • 财政年份:
    2010
  • 资助金额:
    $ 0.38万
  • 项目类别:
STRUCTURAL STUDY OF BACTERIAL TOXINS
细菌毒素的结构研究
  • 批准号:
    8170013
  • 财政年份:
    2010
  • 资助金额:
    $ 0.38万
  • 项目类别:
STUDY OF RADIATION DECAY OF PROTEIN CRYSTALS
蛋白质晶体的辐射衰变研究
  • 批准号:
    8170007
  • 财政年份:
    2010
  • 资助金额:
    $ 0.38万
  • 项目类别:
A TRANSFERASE IN DISORAZOLE SYNTHASE
二甲拉唑合成酶中的转移酶
  • 批准号:
    8169903
  • 财政年份:
    2010
  • 资助金额:
    $ 0.38万
  • 项目类别:
AUTOMATED CRYSTAL QUEUING FOR DATA COLLECTION
用于数据收集的自动水晶排队
  • 批准号:
    8170005
  • 财政年份:
    2010
  • 资助金额:
    $ 0.38万
  • 项目类别:
STUDY OF RADIATION DECAY OF PROTEIN CRYSTALS
蛋白质晶体的辐射衰变研究
  • 批准号:
    7954295
  • 财政年份:
    2009
  • 资助金额:
    $ 0.38万
  • 项目类别:
PURE UNDER CARBON DIOXIDE
纯净低于二氧化碳
  • 批准号:
    7954300
  • 财政年份:
    2009
  • 资助金额:
    $ 0.38万
  • 项目类别:

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