STRUCTURAL STUDY OF BACTERIAL TOXINS

细菌毒素的结构研究

• 批准号: 8362107
• 负责人: IRIMPAN I MATHEWS
• 金额: $ 0.38万
• 依托单位: STANFORD UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-03-01 至 2012-02-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8362107
• 关键词: Bacterial Toxins; Funding; Grant; National Center for Research Resources; Pharmaceutical Preparations; Principal Investigator; Radiation; Research; Research Infrastructure; Resources; Safety; Source; Toxin; United States National Institutes of Health; Work; cost; prevent; structural biology

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. Bacterial toxins cause various pathological effects. The current study proposes to investigate the effect of few known bacterial toxins. The primary aim is to develop potential drugs to treat or prevent toxin related illness. The preliminary studies have generated few potential targets and the structural study is aimed at understanding the mechanism. Due to safety concern, we will be working on genetically modified forms which are inactivated and nontoxic.

该副本是利用资源的众多研究子项目之一 由NIH/NCRR资助的中心赠款提供。对该子弹的主要支持 而且，副投影的主要研究员可能是其他来源提供的 包括其他NIH来源。 列出的总费用可能 代表subproject使用的中心基础架构的估计量， NCRR赠款不直接向子弹或副本人员提供的直接资金。 细菌毒素会引起各种病理作用。当前的研究建议研究很少有已知细菌毒素的作用。主要目的是开发潜在的药物来治疗或预防毒素相关疾病。初步研究产生了很少的潜在目标，结构研究旨在理解该机制。由于安全问题，我们将致力于灭活和无毒的转基因形式。