MECHANISTIC STUDY OF CLC CHLORIDE-TRANSPORT PROTEINS

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目及 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 CLC氯转运蛋白广泛表达。CLC蛋白在神经元、肌肉、心血管和上皮功能中发挥核心作用。 由于这些重要的生理作用，许多是治疗人类疾病的潜在药物靶点。 这些蛋白质的缺陷是人类肾脏和骨骼疾病、血压调节紊乱和癫痫的原因。Maduke实验室的研究涉及电生理学，结构和生物化学方法的组合。 目前的研究利用结构信息来了解CLC抑制的机制。 研究将包括抑制剂。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. CLC chloride-transport proteins are expressed ubiquitously. CLC proteins play central roles in neuronal, muscular, cardiovascular, and epithelial function. Because of these vital physiological roles, many are potential drug targets for treating human disease. Defects in these proteins are responsible for human diseases of kidney and bone, for disorders of blood-pressure regulation, and for epilepsy. Research in the Maduke lab involves a combination of electrophysiological, structural, and biochemical methods. The current study utilizes structural information to understand the mechanism of CLC inhibition. Studies will include inhibitors.