Biomedical Research Informatics for Global Health Training (BRIGHT) Program

描述(由申请者提供)：生物医学研究信息学促进全球健康培训(BREAT)计划是为了在巴西的中低收入环境中建设能力而开发的。在之前的资助期间，我们开发了一个所有国家的项目；我们开发了一个新的临床信息学证书项目，并支持了一个新设立的生物信息学博士项目。随着这些以圣保罗为基地的项目的发展，我们计划将它们的覆盖范围扩展到城市以外的巴西北部地区和莫桑比克的马普托。我们提出了一项计划，该计划将：(1)培训巴西和莫桑比克未来的科学领导者，使其具备使用基因组科学、生物医学和健康信息学工具的能力。为此，它将把重点放在与巴西和莫桑比克特别相关并对全球健康有很大影响的生命科学领域，如艾滋病毒/艾滋病、宫颈癌、结肠癌和乳腺癌。我们将通过两个不同的课程来满足应用信息学研究和基础信息学研究的不同培训需求，这两个课程的持续时间和重点不同：(A)一年制证书课程旨在满足应用生物医学和健康信息学方面的直接人力资源需求(目标与正式硕士课程相似)；以及(B)五年制博士课程强调以现实世界问题为动机的基础信息学研究。(2)加强巴西、莫桑比克和美国研究人员之间的合作和数据共享。重点是信息学带来的合作，我们将利用所有参与的教职员工的研究优势。巴西和莫桑比克的教职员工和受训人员将能够参加国际会议，以进一步发展他们的合作者网络。美国教师将为巴西和莫桑比克学生讲课和共同提供建议，共同开发课程，并反过来获得对巴西、莫桑比克和其他发展中国家的生物医学和卫生信息学问题的了解。 公共卫生相关性：建设信息学能力对于发展中国家能够与美国机构合作遏制HLV/ALDS疫情以及这些机构开展与病毒演变和治疗药物耐药性相关的多中心研究至关重要。

DESCRIPTION (provided by applicant): The Biomedical Research Informatics for Global Health Training (BRIGHT) program was developed to build capacity in medium- and low-income settings in Brazil. An all in-country program was developed, in the previous funding period; we developed a new certificate program in clinical informatics and supported a newly created doctoral program in bioinformatics. As these programs based in Sao Paulo evolve, we plan to extend their reach outside the city, to northern areas of Brazil and to Maputo, Mozambique. We propose a program that will: (1) Train Brazil's and Mozambique's future scientific leaders to be equipped to use tools of genome science, biomedical and health informatics. It will do so by concentrating on life sciences domains that are of particular relevance to Brazil and Mozambique and that have high impact on global health, such as HIV/AIDS, cervical, colon, and breast cancer. We will address the different training needs of applied informatics research and basic informatics research by two distinct programs, which differ in duration and emphasis: (a) A one-year certificate program is aimed at meeting immediate human resource needs in applied biomedical and health informatics, (similar in goals to the formal master's program); and (b) A five-year doctoral program emphasizes basic informatics research that is motivated by real world problems. (2) Strengthen collaborations and data sharing between researchers in Brazil, Mozambique, and the USA. The focus is on cooperation enabled by informatics, and we will take advantage of the strengths of research of all participating faculty. Brazilian and Mozambican faculty and trainees will be able to go to international meetings to further develop their networks of collaborators. U.S. faculty will lecture and co-advise Brazilian and Mozambican students, co-develop curricula, and in turn acquire appreciation for the problems and issues concerning biomedical and health informatics in Brazil, Mozambique, and other dev eloping nations. PUBLIC HEALTH RELEVANCE: Building capacity in informatics is critical for developing countries to be able to partner with U.S. institutions in the containment of the HlV/AlDS epidemic, and for these institutions to perform multi-center research related to the evolution of the virus and resistance to therapeutic agents.