Retroviruses

描述（由申请人提供）：逆转录病毒，2011年5月23日- 28日。本提案寻求对将在冷泉港实验室举行的第36届“逆转录病毒”系列年度会议的支持，该会议已成为该领域的首次会议。该会议将召集该领域的领导者、初级教师、博士后研究员和研究生，讨论逆转录病毒生物学领域的最新前沿发展。该系列会议的重点是病毒及其与宿主细胞的相互作用，而不是它们引起的特定疾病。大部分将要展示的作品将是未发表的，并受到观众的直接评论和讨论。2011年会议的组织方式将与病毒的生物学相似；从复制周期的进入阶段开始，接着是进入后的事件，包括逆转录和整合、rna相关事件（转录、加工、输出和包装）、颗粒组装和释放、发病机制/宿主因子，最后是抗病毒药物和进化。被选中的演讲者将包括研究生、博士后研究员和初级教师。每届会议将由组织者从注册人中选出该领域的两位顶尖科学家主持。两到三名知名的受邀演讲者将做特别讲座，以激励和告知年轻科学家，并激发在相关但不同领域工作的科学家之间的讨论。还将有三次海报会议，大多数参与者可以展示他们的作品。会议规模适中，预计约有450名逆转录病毒学者参加。

DESCRIPTION (provided by applicant): Retroviruses May 23 - 28, 2011. This proposal seeks support for the thirty-sixth in an annual series of meetings on "Retroviruses" to be held at Cold Spring Harbor Laboratory that has emerged as the premiere conference for this field. The proposed meeting will assemble leaders in the field, junior faculty, postdoctoral fellows and graduate students to discuss new, cutting-edge developments in the field of retrovirus biology. The meeting series is focused on the viruses and their interactions with host cells rather than the particular diseases they cause. The large majority of the work to be presented will be unpublished and subject to immediate comment and discussion by the audience. The 2011 meeting will be structured in a manner that parallels the biology of the viruses; beginning with the entry phase of the replication cycle, proceeding with post-entry events, including reverse transcription and integration, RNA-related events (transcription, processing, export, and packaging), particle assembly and release, pathogenesis/host factors, and concluding with antivirals and evolution. Selected speakers will include graduate students, postdoctoral fellows and junior faculty. Each session will be chaired by two leading scientists in the field selected by the organizers from among the registrants. Two or three eminent invited speakers will give special lectures to inspire and inform young scientists and to stimulate discussion between scientists working on related but distinct areas. There will also be three poster sessions where a majority of participants can present their work. The meeting will be of moderate size, and we expect ~450 retrovirologists in attendance. PUBLIC HEALTH RELEVANCE: Retroviruses 2011 Lay Narrative HIV/AIDS is now a major pandemic in human beings throughout the world. According to current estimates, HIV is set to infect 90 million people in Africa, resulting in a minimum estimate of 18 million orphans. Many conferences around the world address a plethora of issues related to the treatment of HIV/AIDS, but few do so by addressing the underlying biology of the virus, and even fewer do this by putting the molecular biology of the virus and its interaction with its human host in the broader context of how all retroviruses, irrespective of host, function and evolve. A key to the success of the Cold Spring Harbor annual retroviruses conference is that the majority of oral presentations are given by graduate students, postdoctoral fellows and junior faculty chosen on the basis of scientific merit, ensuring that the conference showcases the latest developments which are often yet to be published. Participants come from academic centers, research institutes and industrial centers around the world to present and discuss their findings. Many of the currently important treatments for HIV/AIDS were first presented or proposed at this conference in past years. Importantly, this application requests support for junior scientists who might not otherwise be able to attend to actively participate in the meeting.