Retroviruses

描述（由申请人提供）：逆转录病毒2011年5月23日至28日。本提案寻求对将在冷泉港实验室举行的关于“逆转录病毒”的年度系列会议的第三十六次会议的支持，该会议已成为该领域的首要会议。拟议的会议将聚集在该领域的领导人，初级教师，博士后研究员和研究生讨论新的，在逆转录病毒生物学领域的前沿发展。该系列会议的重点是病毒及其与宿主细胞的相互作用，而不是它们引起的特定疾病。绝大多数的工作将被提交将未发表，并受到观众的即时评论和讨论。2011年会议的结构将与病毒的生物学相平行;从复制周期的进入阶段开始，进行进入后事件，包括逆转录和整合，RNA相关事件（转录，加工，输出和包装），颗粒组装和释放，发病机制/宿主因素，并以抗病毒药物和进化结束。选定的演讲者将包括研究生，博士后研究员和初级教师。每次会议将由组织者从登记者中选出的该领域的两名主要科学家主持。两三位杰出的特邀演讲者将发表特别演讲，以激励和告知年轻科学家，并激发从事相关但不同领域工作的科学家之间的讨论。还将有三个海报会议，大多数与会者可以介绍他们的工作。会议将是中等规模，我们预计约450逆转录病毒学家出席。 艾滋病病毒/艾滋病是世界上最严重的艾滋病病毒感染者，也是世界上最严重的艾滋病病毒感染者。根据目前的估计，艾滋病毒将在非洲感染9 000万人，造成至少1 800万孤儿。世界各地的许多会议都讨论了与艾滋病毒/艾滋病治疗有关的大量问题，但很少有人讨论病毒的基本生物学，更少有人将病毒的分子生物学及其与人类宿主的相互作用置于所有逆转录病毒（无论宿主如何）如何发挥作用和进化的更广泛背景下。冷泉港年度逆转录病毒会议成功的关键在于，大多数口头报告都是由根据科学价值选择的研究生、博士后和初级教师进行的，确保会议展示了往往尚未发表的最新进展。与会者来自世界各地的学术中心、研究机构和工业中心，介绍和讨论他们的发现。许多目前重要的艾滋病毒/艾滋病治疗方法都是在过去几年的这次会议上首次提出或提出的。重要的是，这一申请要求支持年轻的科学家，否则他们可能无法参加积极参加会议。

DESCRIPTION (provided by applicant): Retroviruses May 23 - 28, 2011. This proposal seeks support for the thirty-sixth in an annual series of meetings on "Retroviruses" to be held at Cold Spring Harbor Laboratory that has emerged as the premiere conference for this field. The proposed meeting will assemble leaders in the field, junior faculty, postdoctoral fellows and graduate students to discuss new, cutting-edge developments in the field of retrovirus biology. The meeting series is focused on the viruses and their interactions with host cells rather than the particular diseases they cause. The large majority of the work to be presented will be unpublished and subject to immediate comment and discussion by the audience. The 2011 meeting will be structured in a manner that parallels the biology of the viruses; beginning with the entry phase of the replication cycle, proceeding with post-entry events, including reverse transcription and integration, RNA-related events (transcription, processing, export, and packaging), particle assembly and release, pathogenesis/host factors, and concluding with antivirals and evolution. Selected speakers will include graduate students, postdoctoral fellows and junior faculty. Each session will be chaired by two leading scientists in the field selected by the organizers from among the registrants. Two or three eminent invited speakers will give special lectures to inspire and inform young scientists and to stimulate discussion between scientists working on related but distinct areas. There will also be three poster sessions where a majority of participants can present their work. The meeting will be of moderate size, and we expect ~450 retrovirologists in attendance. PUBLIC HEALTH RELEVANCE: Retroviruses 2011 Lay Narrative HIV/AIDS is now a major pandemic in human beings throughout the world. According to current estimates, HIV is set to infect 90 million people in Africa, resulting in a minimum estimate of 18 million orphans. Many conferences around the world address a plethora of issues related to the treatment of HIV/AIDS, but few do so by addressing the underlying biology of the virus, and even fewer do this by putting the molecular biology of the virus and its interaction with its human host in the broader context of how all retroviruses, irrespective of host, function and evolve. A key to the success of the Cold Spring Harbor annual retroviruses conference is that the majority of oral presentations are given by graduate students, postdoctoral fellows and junior faculty chosen on the basis of scientific merit, ensuring that the conference showcases the latest developments which are often yet to be published. Participants come from academic centers, research institutes and industrial centers around the world to present and discuss their findings. Many of the currently important treatments for HIV/AIDS were first presented or proposed at this conference in past years. Importantly, this application requests support for junior scientists who might not otherwise be able to attend to actively participate in the meeting.