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High-frequency-ultrasound annular arrays for ophthalmic and small-animal imaging

用于眼科和小动物成像的高频超声环形阵列

基本信息

批准号：
8049093
负责人：
Jeffrey Ketterling
金额：
$ 35.41万
依托单位：
RIVERSIDE RESEARCH INSTITUTE
依托单位国家：
美国
项目类别：
财政年份：
2008
资助国家：
美国
起止时间：
2008-06-15 至 2012-12-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8049093
关键词：
Age Algorithms Americas Anatomy Animal Experiments Animals Anterior Bathing Biometry Blindness Cardiovascular system Cerebral Ventricles Clinical Code Data Collection Data Display Data Set Detection Development Device or Instrument Development Devices Diabetic Retinopathy Disease Disease Progression Elements Embryo Engineering Eye Eye Banks Frequencies Genetic Goals Grant Human Image Imagery Immersion Investigative Technique Lateral Legal Blindness Marketing Medical Research Mus Noise Ophthalmology Oryctolagus cuniculus Pattern Performance Population Positioning Attribute Posterior Vitreous Detachments Real-Time Systems Research Personnel Resolution Risk Factors Scanning Solutions Specimen Structure System Systems Integration Techniques Technology Testing Three-Dimensional Imaging Time Tissues Transducers Ultrasonography Universities Validation Visual Work base cost data acquisition design disease diagnosis human subject image processing imaging Segmentation improved in vivo instrument interest medical schools mouse development prevent

项目摘要

DESCRIPTION (provided by applicant): The goal of this study is to develop and evaluate advanced annular-array transducer technology for rapid, high-definition imaging in significant medical-research applications. The study will assess high frequency ultrasound (HFU, = 20 MHz) annular arrays in two important applications: 1) imaging microstructure in small animals (e.g., mouse embryos); and 2) imaging posterior vitreous detachments (PVDs) associated with diabetic retinopathy, the leading cause of blindness in the US working-age population according to Prevent Blindness America. Current HFU instruments do not use linear arrays for such applications because of a variety of technical and cost reasons. Instead, current HFU instruments use mechanically scanned, single-element transducers, which provide fine-resolution images over a very limited depth of field (DOF). For small-animal applications, a shallow DOF causes most anatomical boundaries in the specimen to be poorly defined; therefore, accurate micro-structural and volumetric analyses are nearly impossible. For ophthalmic applications, a shallow DOF causes most ocular anatomy to be imaged with poor definition compared to the in-focus region; therefore, because only a small portion of the eye is in focus at a given time, detection and assessment of ocular conditions such as PVD are prone to inaccuracies and false-negative determinations. Annular-array transducers offer a promising approach to significantly extend DOF and to increase the depth range over which fine-lateral resolution is provided. This proposal seeks to continue the HFU annular-array studies initiated under grant EY014371 that demonstrated the improved imaging capability of synthetically-focused annular arrays using in vivo rabbit eyes, in vivo mouse embryos, and human eye-bank eyes. The proposed project will extend those previous studies by developing and validating a real-time HFU, annular-array-based, rapid-imaging system capable of 1) dynamic-receive display imaging at a rate of > 10 fps; 2) data acquisition in < 0.2 s for single-frame, synthetically-focused imaging; and 3) 3D data collection in < 20 s. The proposed system will be modular to facilitate upgrading system components and features. We will validate system performance using animal experiments and human-subject examinations. First, in vivo animal experiments will be conducted with rabbit eyes to evaluate a 40-MHz annular array for anterior-segment imaging and a 20-MHz annular array for posterior segment and full-globe imaging. We also will utilize the 40-MHz annular array to perform in vivo 3D imaging and volumetric segmentation studies with mouse embryos. Second, we will test the hypothesis that 20-MHz annular arrays improve detection of PVD. Validation of this hypothesis will significantly improve our ability to assess disease status in diabetic retinopathy.

描述（由申请人提供）：本研究的目标是开发和评估先进的环形阵列换能器技术，以在重要的医学研究应用中实现快速、高清成像。该研究将评估高频超声（HFU，= 20 MHz）环形阵列的两个重要应用：1）小动物（例如小鼠胚胎）的微观结构成像； 2) 与糖尿病视网膜病变相关的玻璃体后脱离 (PVD) 成像，根据 Prevent Blindness America 的报告，糖尿病视网膜病变是美国劳动年龄人口失明的主要原因。由于各种技术和成本原因，当前的 HFU 仪器不将线性阵列用于此类应用。相反，当前的 HFU 仪器使用机械扫描单元件传感器，可在非常有限的景深 (DOF) 上提供高分辨率图像。对于小动物应用，浅自由度会导致标本中的大多数解剖学边界界定不清；因此，精确的微观结构和体积分析几乎是不可能的。对于眼科应用，浅景深会导致大多数眼部解剖结构的成像清晰度与对焦区域相比较差；因此，由于在给定时间只有一小部分眼睛处于焦点状态，因此对眼部状况（例如 PVD）的检测和评估很容易出现不准确和假阴性的情况。环形阵列传感器提供了一种有前途的方法，可以显着扩展自由度并增加提供精细横向分辨率的深度范围。该提案旨在继续在 EY014371 资助下启动的 HFU 环形阵列研究，该研究证明使用体内兔眼、体内小鼠胚胎和人眼库眼睛的合成聚焦环形阵列的成像能力得到改善。拟议的项目将通过开发和验证实时 HFU、基于环形阵列的快速成像系统来扩展之前的研究，该系统能够 1) 以 > 10 fps 的速率动态接收显示成像； 2) 单帧合成聚焦成像的数据采集时间小于 0.2 秒； 3) 在 < 20 秒内收集 3D 数据。拟议的系统将是模块化的，以方便升级系统组件和功能。我们将通过动物实验和人体检查来验证系统性能。首先，将用兔眼进行体内动物实验，以评估用于前段成像的 40 MHz 环形阵列和用于后段和全球成像的 20 MHz 环形阵列。我们还将利用 40 MHz 环形阵列对小鼠胚胎进行体内 3D 成像和体积分割研究。其次，我们将测试 20 MHz 环形阵列改善 PVD 检测的假设。这一假设的验证将显着提高我们评估糖尿病视网膜病变疾病状态的能力。