ABSORPTION OF LONG CHAIN HIGHLY UNSATURATED FATTY ACIDS
ABSORPTION OF LONG CHAIN HIGHLY UNSATURATED FATTY ACIDS
批准号:
8167024
负责人:
RICHARD B WEINBERG
金额:
$3.63万
依托单位国家:
美国
项目类别:
财政年份:
2010
资助国家:
美国
项目状态:
已结题
起止时间:
2010-03-01 至 2011-02-28
关键词:
AdultAffectComputer Retrieval of Information on Scientific Projects DatabaseDataDietary FatsEquilibriumFDA approvedFat SubstitutesFatty acid glycerol estersFundingGenesGenetic PolymorphismGenetic VariationGrantInfantInstitutionIntestinesMeasurementNatureOmega-3 Fatty AcidsPilot ProjectsResearchResearch PersonnelResourcesSourceSucroseUnited States National Institutes of HealthUnsaturated Fatty Acidsabsorptionbase
中文摘要
这个子项目是许多利用
由NIH/NCRR资助的中心赠款提供的资源。子项目和
研究者(PI)可能从另一个NIH来源获得了主要资金,
因此可在其他CRISP条目中表示。所列机构为
研究中心,而研究中心不一定是研究者所在的机构。
对婴儿的研究表明,长链高度不饱和脂肪酸(LCHUFA,omega-3脂肪酸)的吸收效率低于其他膳食脂肪。脂肪平衡研究的繁琐性阻碍了研究人员确认这种差异在成年人中的存在。此外,我们最近在GCRC中进行的一项初步研究的数据表明,APOA 4基因的遗传变异可能会调节LCHUFA吸收的效率。Jandacek等人已经确定,蔗糖聚山嵛酸酯(FDA批准的脂肪替代品Olestra的一种组分)可以作为高度准确测量肠道膳食脂肪吸收的不可吸收标志物。我们提出了一个试点GCRC为基础的研究,以检查是否载脂蛋白4 T347 S多态性影响的效率与饮食中的LCHUFA吸收成人。
英文摘要
This subproject is one of many research subprojects utilizing the
resources provided by a Center grant funded by NIH/NCRR. The subproject and
investigator (PI) may have received primary funding from another NIH source,
and thus could be represented in other CRISP entries. The institution listed is
for the Center, which is not necessarily the institution for the investigator.
Studies in infants suggest that long chain highly unsaturated fatty acids (LCHUFA, omega-3 fatty acids) are absorbed with less efficiency that other dietary fats. The cumbersome nature of fat balance studies has deterred researchers from confirming that this difference maintains in adults. Moreover, data from a pilot study we recently conducted in the GCRC suggest that genetic variation in the APOA4 gene may modulate the efficiency of LCHUFA absorption. Jandacek et al. have established that sucrose polybehenate, a component of the FDA approved fat substitute Olestra, can serve as an non-absorbable marker in a highly accurate measurement of intestinal dietary fat absorption. We propose a pilot GCRC-based study to examine whether the APO4 T347S polymorphism affects the efficiency with which dietary LCHUFA are absorbed in adults.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
EFFECTS OF EZETIMIBE ON ABSORPTION OF DIETARY FATTY ACIDS-GCRC PILOT STUDY
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批准号:8167058
-
项目类别:
-
资助金额:$7.9万
-
财政年份:2010
-
负责人:RICHARD B WEINBERG
-
依托单位:
ABSORPTION OF LONG CHAIN HIGHLY UNSATURATED FATTY ACIDS
-
批准号:7951396
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项目类别:
-
资助金额:$10.03万
-
财政年份:2009
-
负责人:RICHARD B WEINBERG
-
依托单位:
TRANSPORT OF DIETARY LONG CHAIN FATTY ACIDS INTO HUMAN BREAST MILK
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批准号:7203803
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项目类别:
-
资助金额:$0.17万
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财政年份:2005
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负责人:RICHARD B WEINBERG
-
依托单位:
Effect of the Apo A-IV-2 Allele on the Post Prandial Response to Dietary Fat
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批准号:7045669
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项目类别:
-
资助金额:$2.01万
-
财政年份:2004
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负责人:RICHARD B WEINBERG
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依托单位:
Neonatal Nutrition and the Genetics of Human Lactation
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批准号:6534767
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项目类别:
-
资助金额:$14.4万
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财政年份:2002
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负责人:RICHARD B WEINBERG
-
依托单位:
Neonatal Nutrition and the Genetics of Human Lactation
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批准号:6637855
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项目类别:
-
资助金额:$14.4万
-
财政年份:2002
-
负责人:RICHARD B WEINBERG
-
依托单位:
EFFECT OF APO A-IV-2 ALLELE ON THE RESPONSE TO DIETARY FAT AND CHOLESTEROL
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批准号:6309903
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项目类别:
-
资助金额:$3.88万
-
财政年份:1999
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负责人:RICHARD B WEINBERG
-
依托单位:
EFFECT OF APO A IV 2 ALLELE ON POST PRANDIAL RESPONSE TO DIETARY FAT
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批准号:6309915
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项目类别:
-
资助金额:$3.88万
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财政年份:1999
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负责人:RICHARD B WEINBERG
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依托单位:
EFFECT OF APO A IV 2 ALLELE ON POST PRANDIAL RESPONSE TO DIETARY FAT
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批准号:6122761
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项目类别:
-
资助金额:$3.88万
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财政年份:1998
-
负责人:RICHARD B WEINBERG
-
依托单位:
EFFECT OF APO A-IV-2 ALLELE ON THE RESPONSE TO DIETARY FAT AND CHOLESTEROL
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批准号:6122731
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项目类别:
-
资助金额:$3.88万
-
财政年份:1998
-
负责人:RICHARD B WEINBERG
-
依托单位:
EFFECT OF APO A IV 2 ALLELE ON POST PRANDIAL RESPONSE TO DIETARY FAT
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批准号:6282796
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项目类别:
-
资助金额:$3.63万
-
财政年份:1997
-
负责人:RICHARD B WEINBERG
-
依托单位:
EFFECT OF APO A-IV-2 ALLELE ON THE RESPONSE TO DIETARY FAT AND CHOLESTEROL
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批准号:6282766
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项目类别:
-
资助金额:$3.63万
-
财政年份:1997
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负责人:RICHARD B WEINBERG
-
依托单位:
EFFECT OF APO A-IV-2 ALLELE ON THE RESPONSE TO DIETARY FAT AND CHOLESTEROL
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批准号:6253755
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项目类别:
-
资助金额:$3.61万
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财政年份:1997
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负责人:RICHARD B WEINBERG
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依托单位:
NUTRIENT ANTIOXIDANT DEFENSE OF HIGH DENSITY LIPOPROTEIN
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批准号:2054233
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项目类别:
-
资助金额:$17.79万
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财政年份:1996
-
负责人:RICHARD B WEINBERG
-
依托单位:
NUTRIENT ANTIOXIDANT DEFENSE OF HIGH DENSITY LIPOPROTEIN
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批准号:2732559
-
项目类别:
-
资助金额:$15.79万
-
财政年份:1996
-
负责人:RICHARD B WEINBERG
-
依托单位:
NUTRIENT ANTIOXIDANT DEFENSE OF HIGH DENSITY LIPOPROTEIN
-
批准号:2442290
-
项目类别:
-
资助金额:$17.87万
-
财政年份:1996
-
负责人:RICHARD B WEINBERG
-
依托单位:
STRUCTURE AND FUNCTION OF HUMAN APOLIPOPROTEIN A-IV
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批准号:2430634
-
项目类别:
-
资助金额:$12.31万
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财政年份:1990
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负责人:RICHARD B WEINBERG
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依托单位:
STRUCTURE AND LIPID BINDING OF HUMAN APOLIPOPROTEIN
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批准号:3341896
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项目类别:
-
资助金额:$8.42万
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财政年份:1990
-
负责人:RICHARD B WEINBERG
-
依托单位:
Structure and Function of Apolipoprotein A-IV
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批准号:7102509
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项目类别:
-
资助金额:$35.88万
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财政年份:1990
-
负责人:RICHARD B WEINBERG
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依托单位:
STRUCTURE AND FUNCTION OF APOLIPOPROTEIN A-IV
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批准号:6526671
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项目类别:
-
资助金额:$28.8万
-
财政年份:1990
-
负责人:RICHARD B WEINBERG
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依托单位:
海外基金