ABSORPTION OF LONG CHAIN HIGHLY UNSATURATED FATTY ACIDS

这个子项目是许多利用 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 对婴儿的研究表明，长链高度不饱和脂肪酸（LCHUFA，omega-3脂肪酸）的吸收效率低于其他膳食脂肪。脂肪平衡研究的繁琐性阻碍了研究人员确认这种差异在成年人中的存在。此外，我们最近在GCRC中进行的一项初步研究的数据表明，APOA 4基因的遗传变异可能会调节LCHUFA吸收的效率。Jandacek等人已经确定，蔗糖聚山嵛酸酯（FDA批准的脂肪替代品Olestra的一种组分）可以作为高度准确测量肠道膳食脂肪吸收的不可吸收标志物。我们提出了一个试点GCRC为基础的研究，以检查是否载脂蛋白4 T347 S多态性影响的效率与饮食中的LCHUFA吸收成人。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Studies in infants suggest that long chain highly unsaturated fatty acids (LCHUFA, omega-3 fatty acids) are absorbed with less efficiency that other dietary fats. The cumbersome nature of fat balance studies has deterred researchers from confirming that this difference maintains in adults. Moreover, data from a pilot study we recently conducted in the GCRC suggest that genetic variation in the APOA4 gene may modulate the efficiency of LCHUFA absorption. Jandacek et al. have established that sucrose polybehenate, a component of the FDA approved fat substitute Olestra, can serve as an non-absorbable marker in a highly accurate measurement of intestinal dietary fat absorption. We propose a pilot GCRC-based study to examine whether the APO4 T347S polymorphism affects the efficiency with which dietary LCHUFA are absorbed in adults.