ABSORPTION OF LONG CHAIN HIGHLY UNSATURATED FATTY ACIDS

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 对婴儿的研究表明，与其他饮食脂肪相比，长链高不饱和脂肪酸(LCHUFA，omega-3脂肪酸)的吸收效率较低。脂肪平衡研究的繁琐性质阻止了研究人员证实这种差异在成年人中仍然存在。此外，我们最近在GCRC进行的一项初步研究的数据表明，APOA4基因的遗传变异可能调节LCHUFA的吸收效率。Jandacek等人。已经证实，作为FDA批准的脂肪替代品Olestra的一种成分，蔗糖聚苯乙酸酯可以作为一种非吸收标记物，用于高度准确地测量肠道膳食脂肪吸收。我们提出了一项基于GCRC的先导性研究，以检验APO4 T347S多态是否影响成年人饮食中LCHUFA的吸收效率。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Studies in infants suggest that long chain highly unsaturated fatty acids (LCHUFA, omega-3 fatty acids) are absorbed with less efficiency that other dietary fats. The cumbersome nature of fat balance studies has deterred researchers from confirming that this difference maintains in adults. Moreover, data from a pilot study we recently conducted in the GCRC suggest that genetic variation in the APOA4 gene may modulate the efficiency of LCHUFA absorption. Jandacek et al. have established that sucrose polybehenate, a component of the FDA approved fat substitute Olestra, can serve as an non-absorbable marker in a highly accurate measurement of intestinal dietary fat absorption. We propose a pilot GCRC-based study to examine whether the APO4 T347S polymorphism affects the efficiency with which dietary LCHUFA are absorbed in adults.