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EFFECT OF APO A IV 2 ALLELE ON POST PRANDIAL RESPONSE TO DIETARY FAT

EFFECT OF APO A IV 2 ALLELE ON POST PRANDIAL RESPONSE TO DIETARY FAT
APO A IV 2 等位基因对餐后膳食脂肪反应的影响
批准号：
6309915
负责人：
RICHARD B WEINBERG
金额：
$3.88万
依托单位：
WAKE FOREST UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
1999
资助国家：
美国
项目状态：
已结题
起止时间：
1999-12-01 至 2001-02-28
来源：
https://reporter.nih.gov/project-details/6309915
关键词：
alleles apolipoproteins atherosclerosis blood lipoprotein metabolism cholesterol clinical research dietary lipid disease /disorder proneness /risk genetic susceptibility human subject hyperlipidemia nutrition related tag

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中文摘要
翻译
载脂蛋白A-IV是一种在肠道中发现的脂质结合蛋白，其在膳食脂肪的吸收中起作用。 一种遗传变异，载脂蛋白A-IV-2，已被发现影响多少饮食胆固醇改变血液中的胆固醇。 该项目的目的是研究这种变异基因的工作机制。 研究人员对携带A-IV-2基因的研究对象和不携带A-IV-2基因的对照组进行了研究，以测量他们从饮食中吸收了多少胆固醇。 这些受试者的饮食中含有已知量的胆固醇，但脂肪的数量和类型不同。
英文摘要
Apolipoprotein A-IV is a lipid binding protein found in the intestine, which plays a role in the absorption of dietary fat. A genetic variation, apo A-IV-2, has been found to affect how much dietary cholesterol changes cholesterol in the blood. The purpose of this project was to examine the mechanism by which this variant gene works. Research subjects carrying the A-IV-2 gene, and a control group of subjects who do not, were studied to measure how much cholesterol they absorb from the diet. The subjects were fed diets containing known amounts of cholesterol but different amounts and types of fat.
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