EFFECT OF APO A IV 2 ALLELE ON POST PRANDIAL RESPONSE TO DIETARY FAT

APO A IV 2 等位基因对餐后膳食脂肪反应的影响

• 批准号: 6122761
• 负责人: RICHARD B WEINBERG
• 金额: $ 3.88万
• 依托单位: WAKE FOREST UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-12-01 至 1999-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6122761
• 关键词: alleles; apolipoproteins; atherosclerosis; blood lipoprotein metabolism; cholesterol; clinical research; dietary lipid; disease /disorder proneness /risk; genetic susceptibility; human subject; hyperlipidemia; nutrition related tag

The human response to dietary fat and cholesterol is highly variable. It has been observed that the variant allele,apo A-IV-2, attenuates the increase in LDL cholesterol diet, but the mechanism of the allele effect are unknown. The purpose of this study is to find out how this gene affects the metabolism of dietary fat in the bloodstream. Understanding the effect of the apo A-IV-2 allele on diet-induced hyperlipidemia will further elucidate the impact of genetics on the risk for artherosclerosis.

人体对膳食脂肪和胆固醇的反应是高度可变的。它 已经观察到变体等位基因apo A-IV-2减弱了 增加低密度脂蛋白胆固醇饮食，但等位基因的作用机制 是未知的。 这项研究的目的是找出这个基因是如何 影响血液中膳食脂肪的代谢。 理解 载脂蛋白A-IV-2等位基因对饮食诱导的高脂血症的影响将 进一步阐明遗传学对关节炎风险的影响。