EFFECT OF APO A-IV-2 ALLELE ON THE RESPONSE TO DIETARY FAT AND CHOLESTEROL

APO A-IV-2 等位基因对膳食脂肪和胆固醇反应的影响

• 批准号: 6122731
• 负责人: RICHARD B WEINBERG
• 金额: $ 3.88万
• 依托单位: WAKE FOREST UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-12-01 至 1999-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6122731
• 关键词: alleles; apolipoproteins; cholesterol; clearance rate; clinical research; clinical trials; dietary lipid; gastrointestinal nutrient absorption; gene expression; human subject; hypercholesterolemia; lipid metabolism; nutrition related tag; triglycerides

The human response to dietary cholesterol is highly variable. The impact of the variant allele apo A-IV-2 on the response to dietary saturated fat and the mechanisms of the allele are unknown. Dr. Weinberg proposes a matched, controlled dietary trial with lipid measurement, fractional cholesterol absorption and post-prandial triglyceride clearance. Defining the effect of the apo A-IV-2 allele on diet-induced hypercholoesterolemia will further elucidate the impact of genetics on cholesterol metabolism.

人类对饮食胆固醇的反应是高度可变的。 的影响 变异等位基因apo A-IV-2对膳食饱和脂肪的反应 等位基因的作用机制尚不清楚。 温伯格博士提出了一个 配对对照膳食试验，血脂测量，部分 胆固醇吸收和餐后甘油三酯清除。 限定 载脂蛋白A-IV-2等位基因对饮食诱导的高胆固醇血症的影响 将进一步阐明遗传对胆固醇代谢的影响。