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EFFECT OF APO A-IV-2 ALLELE ON THE RESPONSE TO DIETARY FAT AND CHOLESTEROL

EFFECT OF APO A-IV-2 ALLELE ON THE RESPONSE TO DIETARY FAT AND CHOLESTEROL
APO A-IV-2 等位基因对膳食脂肪和胆固醇反应的影响
批准号：
6309903
负责人：
RICHARD B WEINBERG
金额：
$3.88万
依托单位：
WAKE FOREST UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
1999
资助国家：
美国
项目状态：
已结题
起止时间：
1999-12-01 至 2001-02-28
来源：
https://reporter.nih.gov/project-details/6309903
关键词：
alleles apolipoproteins cholesterol clearance rate clinical research clinical trials dietary lipid gastrointestinal nutrient absorption gene expression human subject hypercholesterolemia lipid metabolism nutrition related tag triglycerides

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中文摘要
翻译
载脂蛋白a - iv是一种在肠道中发现的脂质结合蛋白，在膳食脂肪的吸收中起作用。一种名为载脂蛋白A- iv -2的基因变异被发现会影响膳食胆固醇对血液中胆固醇的影响程度。我们研究了两组受试者，一组携带基因变异a - iv -2，这种变异会影响饮食中胆固醇的吸收，另一组是正常的对照组，以确定他们代谢脂肪的速度。
英文摘要
Apolipoprotein A-IV is a lipid binding protein found in the intestine, which plays a role in the absorption of dietary fat. A genetic variation, apo A-IV-2, has been found to affect how much dietary cholesterol changes cholesterol in the blood. We studied two groups of subjects, one group which carried the genetic variation, A-IV-2, which can affect dietary cholesterol absorption, and a normal control group, to determine how rapidly they could metabolize fat.
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