Enhancing Alcoholism Pharmacotherapy Research via Behavioral Economics

描述（由申请人提供）：这是第一次重新提交K23指导患者导向研究职业奖申请，为James MacKillop博士提供必要的指导和培训，以开展高质量的研究，利用行为经济学来加强酒精中毒药物治疗的研究。行为经济学方法可以通过关注药物对酒精相对价值的影响，促进机制分析，并提供更大的翻译一致性，从而加强药物治疗研究。职业发展/培训计划包括以下培训：1)神经科学和神经药理学；酒精中毒药物治疗研究的实验室方法；3)酒精中毒药物治疗的临床方法研究；4)高级行为经济学；5)专业发展；6)负责任的研究行为。培训将由指导团队监督，该团队由Robert Swift， MD, PhD（赞助商），Peter Monti, PhD（共同赞助商），Jennifer Tidey, PhD（顾问）和Robert Miranda， Jr., PhD（顾问）组成。培训计划还包括一个实证研究项目，使用行为经济学来检验托吡酯（TOP）的效果，这是一种很有前途的新型药物疗法。该研究将招募60名不寻求治疗的酒精依赖者，并采用2 （TOP 300 mg/安慰剂）x2（中性/上升肢）混合设计，在中性条件下和血液酒精曲线上升肢期间研究TOP的效果。基于其假定的神经药理作用和相关的临床数据，预测TOP可以降低酒精在两种行为经济学指标上的相对价值，并将研究TOP效应的潜在介质。为了探索目的，还将在血液酒精曲线下降时检查TOP的影响。除了作为关键的训练，这项研究可能有重要的临床和方法学意义。研究与公共卫生的相关性：治疗酒精中毒的药物具有相当大的前景，行为经济学可能会加强这一领域的研究。这项K23指导患者导向研究事业奖提案是为了让James MacKillop博士获得进行此类研究的专业知识。培训计划包括指导、培训和一项使用行为经济学研究托吡酯（一种很有前景的治疗酒精中毒的药物）效果的研究。

DESCRIPTION (provided by applicant): This is the first resubmission of a K23 Mentored Patient-Oriented Research Career Award application to provide James MacKillop, PhD, with the necessary mentorship and training to conduct high-quality research using behavioral economics to enhance research on pharmacotherapies for alcoholism. A behavioral economic approach may enhance pharmacotherapy research by focusing on medication effects on the relative value of alcohol, facilitating mechanistic analyses, and providing greater translational consilience. The Career Development/Training Plan includes training in: 1) neuroscience and neuropharmacology; 2) laboratory methods in alcoholism pharmacotherapy research; 3) clinical methods for alcoholism pharmacotherapy research; 4) advanced behavioral economics; 5) professional development; 6) responsible conduct of research. The training will be overseen by a mentorship team comprised of Robert Swift, MD, PhD (Sponsor), Peter Monti, PhD (Co-Sponsor), Jennifer Tidey, PhD (Advisor), and Robert Miranda, Jr., PhD (Advisor). The training plan also includes an empirical research project using behavioral economics to examine the effects of topiramate (TOP), a promising novel pharmacotherapy. The proposed study will recruit 60 alcohol dependent individuals who are not seeking treatment and study the effects of TOP under neutral conditions and during the ascending limb of the blood alcohol curve, using a 2 (TOP 300 mg/placebo) X 2 (neutral/ascending limb) mixed design. Based on its putative neuropharmacological actions and correlational clinical data, TOP is predicted to reduce the relative value of alcohol on two behavioral economic measures and potential mediators of TOP'S effects will be examined. For exploratory purposes, the effects of TOP will also be examined during the descending limb of the blood alcohol curve. In addition to serving as critical training, this research may have important clinical and methodological implications. RELEVANCE OF THE RESEARCH TO PUBLIC HEALTH: Medications for treating alcoholism have considerable promise and behavioral economics may enhance research in this area. This K23 Mentored Patient-Oriented Research Career Award proposal is for Dr. James MacKillop to gain the expertise to conduct such research. The training plan includes mentorship, training, and a research study using behavioral economics to study the effects of topiramate, a promising medication for alcoholism.