Enhancing Alcoholism Pharmacotherapy Research via Behavioral Economics

描述（由申请人提供）：这是K23指导的以患者为导向的研究职业奖申请的第一次重新提交，为James MacKillop博士提供必要的指导和培训，利用行为经济学进行高质量的研究，以加强对酒精中毒药物疗法的研究。行为经济学方法可以通过关注药物对酒精相对价值的影响，促进机制分析，并提供更大的翻译一致性来加强药物治疗研究。职业发展/培训计划包括以下培训：1）神经科学和神经药理学; 2）酒精中毒药物治疗研究的实验室方法; 3）酒精中毒药物治疗研究的临床方法; 4）高级行为经济学; 5）专业发展; 6）负责任的研究行为。培训将由一个导师团队监督，该团队由Robert Swift，MD，PhD（赞助商），Peter Monti，PhD（联合赞助商），Jennifer Tidey，PhD（顾问）和Robert米兰达，Jr.组成，博士（顾问）。培训计划还包括一个使用行为经济学的实证研究项目，以检查托吡酯（TOP），一种有前途的新型药物治疗的影响。拟议的研究将招募60名未寻求治疗的酒精依赖者，并使用2（TOP 300 mg/安慰剂）X 2（中性/上升肢体）混合设计，研究TOP在中性条件下和血液酒精曲线上升肢体期间的影响。基于其假定的神经药理学作用和相关的临床数据，TOP预计将降低酒精对两种行为经济措施的相对价值，并将检查TOP效应的潜在介质。出于探索性目的，还将在血液酒精曲线的下降段检查TOP的影响。除了作为关键的培训，这项研究可能有重要的临床和方法的影响。研究与公共卫生的相关性：治疗酒精中毒的药物有相当大的前景，行为经济学可能会加强这一领域的研究。这个K23指导的以患者为导向的研究职业奖的建议是博士詹姆斯麦基洛普获得专业知识进行这样的研究。培训计划包括指导、培训和一项研究，该研究使用行为经济学来研究托吡酯（一种有前途的治疗酒精中毒的药物）的效果。

DESCRIPTION (provided by applicant): This is the first resubmission of a K23 Mentored Patient-Oriented Research Career Award application to provide James MacKillop, PhD, with the necessary mentorship and training to conduct high-quality research using behavioral economics to enhance research on pharmacotherapies for alcoholism. A behavioral economic approach may enhance pharmacotherapy research by focusing on medication effects on the relative value of alcohol, facilitating mechanistic analyses, and providing greater translational consilience. The Career Development/Training Plan includes training in: 1) neuroscience and neuropharmacology; 2) laboratory methods in alcoholism pharmacotherapy research; 3) clinical methods for alcoholism pharmacotherapy research; 4) advanced behavioral economics; 5) professional development; 6) responsible conduct of research. The training will be overseen by a mentorship team comprised of Robert Swift, MD, PhD (Sponsor), Peter Monti, PhD (Co-Sponsor), Jennifer Tidey, PhD (Advisor), and Robert Miranda, Jr., PhD (Advisor). The training plan also includes an empirical research project using behavioral economics to examine the effects of topiramate (TOP), a promising novel pharmacotherapy. The proposed study will recruit 60 alcohol dependent individuals who are not seeking treatment and study the effects of TOP under neutral conditions and during the ascending limb of the blood alcohol curve, using a 2 (TOP 300 mg/placebo) X 2 (neutral/ascending limb) mixed design. Based on its putative neuropharmacological actions and correlational clinical data, TOP is predicted to reduce the relative value of alcohol on two behavioral economic measures and potential mediators of TOP'S effects will be examined. For exploratory purposes, the effects of TOP will also be examined during the descending limb of the blood alcohol curve. In addition to serving as critical training, this research may have important clinical and methodological implications. RELEVANCE OF THE RESEARCH TO PUBLIC HEALTH: Medications for treating alcoholism have considerable promise and behavioral economics may enhance research in this area. This K23 Mentored Patient-Oriented Research Career Award proposal is for Dr. James MacKillop to gain the expertise to conduct such research. The training plan includes mentorship, training, and a research study using behavioral economics to study the effects of topiramate, a promising medication for alcoholism.