Enhancing Alcoholism Pharmacotherapy Research via Behavioral Economics

描述(由申请人提供)：本K23指导患者导向研究事业奖的建议是为James MacKillop博士提供必要的指导和培训，以利用行为经济学进行高质量的研究，以加强酒精中毒药物疗法的研究。行为经济学方法可以通过关注药物对酒精自我给药的影响，促进机制分析，并提供更大的翻译一致性，来加强药物治疗研究。职业发展/培训计划包括以下培训：1)神经科学和精神药理学；2)酒精中毒药物治疗研究的实验室方法；3)酒精中毒药物治疗研究的临床方法；4)行为经济学的高级培训；5)职业发展；6)负责任的研究行为。培训将由一个由罗伯特·斯威夫特医学博士(赞助商)、彼得·蒙蒂博士(共同赞助商)、詹妮弗·蒂迪博士(顾问)和小罗伯特·米兰达博士(顾问)组成的导师团队监督。培训计划还提出了一个使用行为经济学的实证研究项目，以检查托吡酯(TOP)的效果，托吡酯是一种有前途的新型药物疗法。这项拟议的研究将招募60名没有寻求治疗的酒精依赖者，并研究TOP在以下情况下的效果 中性条件和上升肢体的血液酒精曲线，采用2(顶部SOO mg/安慰剂)×2(中性/上升肢体)混合设计。 根据其可能的神经药理作用和相关的临床数据，预计TOP将从两个行为经济学措施上减少酒精自我给药。出于探索的目的，我们还将在血液酒精曲线下降的过程中检查TOP的影响。除了作为批判性训练，这项研究还可能具有重要的临床和方法学意义。这项研究与公共健康的相关性：治疗酒精中毒的药物有相当大的前景，行为经济学可能会加强这一领域的研究。这项提议是为James MacKillop博士申请K23指导患者导向研究职业奖，以获得追求这一前景的专业知识，包括指导、培训和一项使用行为经济学研究托吡酯的实证研究，托吡酯是一种有前景的治疗酒精中毒的新药。

DESCRIPTION (provided by applicant): This proposal for a K23 Mentored Patient-Oriented Research Career Award is to provide James MacKillop, PhD, with the necessary mentorship and training to conduct high-quality research using behavioral economics to enhance research on pharmacotherapies for alcoholism. A behavioral economic approach may enhance pharmacotherapy research by focusing on medication effects on alcohol self-administration, facilitating mechanistic analyses, and providing greater translational consilience. The Career Development/Training Plan includes training in: 1) neuroscience and psychopharmacology; 2) laboratory methods for alcoholism pharmacotherapy research; 3) clinical methods for alcoholism pharmacotherapy research; 4) advanced training in behavioral economics; 5) professional development; 6) responsible conduct of research. The training will be overseen by a mentorship team comprised of Robert Swift, MD, PhD (Sponsor), Peter Monti, PhD (Co-Sponsor), Jennifer Tidey, PhD (Advisor), and Robert Miranda, Jr., PhD (Advisor). The training plan also proposes an empirical research project using behavioral economics to examine the effects of topiramate (TOP), a promising novel pharmacotherapy. The proposed study will recruit 60 alcohol dependent individuals who are not seeking treatment and study the effects of TOP under neutral conditions and during the ascending limb of the blood alcohol curve, using a 2 (TOP SOOmg/placebo) X 2 (neutral/ascending limb) mixed design. Based on its putative neuropharmacological actions and correlational clinical data, TOP is predicted to reduce alcohol self-administration on two behavioral economic measures. For exploratory purposes, the effects of TOP will also be examined during the descending limb of the blood alcohol curve. In addition to serving as criticial training; this research may have important clinical and methodological implications. RELEVANCE OF THE RESEARCH TO PUBLIC HEALTH: Medications for treating alcoholism have considerable promise and behavioral economics may enhance research in this area. This proposal is an application for a K23 Mentored Patient-Oriented Research Career Award for Dr. James MacKillop to gain the expertise to pursue this prospect, including mentorship, training, and an empirical study using behavioral economics to study topiramate, a promising new medication for alcoholism.