Task Specific Project 1

特定任务的项目 特定于任务的项目简介 我们为该计划的第一年选择了两个特定于任务的项目，以支持目标1 课题1中胃癌探针的研究进展和基于拉曼颗粒的分子 在特定于任务的项目中使用仪器和探测器2。其目的是支持第一个项目的早期开发 多年的计划，并在未来几年内与特定任务的项目一起走向翻译。在……里面 特定任务项目1研究人员将筛选胃病早期标志物的噬菌体展示文库 使用来自高危个体的组织来患癌症。在特定任务的项目2中，团队将评估拉曼 仪器和纳米颗粒作为多路早期检测和疾病分期的工具。成象 在许多情况下，仪器已经发展得很好，但却是疾病的分子标志物 这些仪器已经落后了，这是强调分子探针的原因之一 在这个项目和早期的特定任务项目中。有了我们的特定任务项目，决定 在分子成像领域的试剂方面投入大量资金，因为我们认为这些将具有 对疾病管理的重大影响，将补充我们目前在仪器设备方面的优势，以及 在我们最近在分子探针临床翻译方面取得的成功的基础上。

TASK-SPECIFIC PROJECTS INTRODUCTION TO TASK-SPECIFIC PROJECTS We have selected two task-specific projects for the first year of this program that support aim 1 with the development of gastric cancer probes in task-specific project 1, and Raman particle-based molecular instruments and probes in task-specific project 2. The intent is to support early development in the first years of the program and move towards translation with the task-specific projects in the out years. In task-specific project 1 the investigators will screen phage display libraries for early markers of gastric cancer using tissue from high-risk individuals. In task-specific project 2 the team will evaluate Raman instrumentation and nanoparticles as tools for multiplexed early detection and disease staging. Imaging instrumentation has been, in many cases, well-developed but the molecular markers of disease for use with these instruments has lagged behind, and this is one reason for an emphasis on molecular probes in this program and in the early task-specific projects. With our task-specific projects have decided to invest significantly in the reagents side of the molecular imaging field because we feel these will have a significant impact on disease management, will complement our current strengths in instrumentation, and build on our recent successes in clinical translation of molecular probes.