任务具体项目 1-猫眼课题宝

任务具体项目 1

批准号：

7911706

负责人：

JACQUES VAN DAM

金额：

$7.28万

依托单位：

STANFORD UNIVERSITY

依托单位国家：

美国

项目类别：

财政年份：

资助国家：

美国

项目状态：

未结题

起止时间：

至

来源：

https://reporter.nih.gov/project-details/7911706

关键词：

Adult Age Bacteriophages Binding CDH1 gene Cancer Patient Cancerous Canis familiaris Carcinoma in Situ Case Study Cell surface Chronic Clinical Complement Conflict (Psychology)Data Development Diffuse Disease Disease Management Disease Marker Disease Progression E-Cadherin Early Diagnosis Eligibility Determination Endoscopy Etiology Exhibits Fluorescent Dyes Gastrectomy Gastric Tissue Gastric mucosa Gene Mutation Germ-Line Mutation Helicobacter pylori Histologic Image Individual Inflammation Inherited Label Lesion Libraries Malignant Neoplasms Maps Microscopic Molecular Molecular Probes Mucous Membrane Mus Mutation Normal tissue morphology P-Cadherin Patient Monitoring Patients Penetrance Peptide Library Peptides Phage Display Predisposition Principal Investigator Proteins Protocols documentation Reagent Research Infrastructure Research Personnel Risk Safety Sampling Screening procedure Side Signet Ring Cell Signet Ring Cell Carcinoma Site Source Specimen Staging Stomach Submucosa Surface Syndrome Testing Time Tissue Banking Tissue Banks Tissue Sample Tissues Topical agent Toxic effect Translations Validation Woman base burden of illness cancer diagnosis cohort disease mechanisms study efficacy testing high risk instrument instrumentation malignant stomach neoplasm molecular imaging molecular marker multimodality mutation carrier nanoparticle particle programs protein expression success tool trend volunteer

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英文摘要

TASK-SPECIFIC PROJECTS INTRODUCTION TO TASK-SPECIFIC PROJECTS We have selected two task-specific projects for the first year of this program that support aim 1 with the development of gastric cancer probes in task-specific project 1, and Raman particle-based molecular instruments and probes in task-specific project 2. The intent is to support early development in the first years of the program and move towards translation with the task-specific projects in the out years. In task-specific project 1 the investigators will screen phage display libraries for early markers of gastric cancer using tissue from high-risk individuals. In task-specific project 2 the team will evaluate Raman instrumentation and nanoparticles as tools for multiplexed early detection and disease staging. Imaging instrumentation has been, in many cases, well-developed but the molecular markers of disease for use with these instruments has lagged behind, and this is one reason for an emphasis on molecular probes in this program and in the early task-specific projects. With our task-specific projects have decided to invest significantly in the reagents side of the molecular imaging field because we feel these will have a significant impact on disease management, will complement our current strengths in instrumentation, and build on our recent successes in clinical translation of molecular probes.

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