BACTERIAL MODEL ECOLOGIES

细菌模型生态学

• 批准号: 8182483
• 负责人: Robert H. Austin
• 金额: $ 79.61万
• 依托单位: PRINCETON UNIVERSITY
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/8182483
• 关键词: Antibiotics; Bacteria; Bacterial Model; Biology; Cells; Communities; Conflict (Psychology); Ecology; Ecosystem; Evolution; Genomics; Genotype; Lead; Link; Malignant Neoplasms; Mammalian Cell; Mechanics; Microbe; Nanotechnology; Organism; Pathway Analysis; Phenotype; Physics; Play; Proteomics; Resistance; Role; Scientist; Signal Transduction; Stress; Structure; Techniques; Technology; Toxin; bacterial resistance; cell motility; design; driving force; insight; model design; new technology; research study

Microbiologists are starting to shift from a single-cell-centered view of microbes towards a more multicellular, demography-centered one, and realizing that evolution and adaptation is closely linked with the community dynamics of cells and how they interact, very much lil<e many-body physics in fact reveals emergent phenomena. This project marries evolution biology with nanotechnology and the intellectual approach of a physicist. The physicist approach used here is two-fold: (1) To exploit a new technology developed using the techniques of physics, (2) To conduct fundamental experiments and analysis on something simple but important: bacterial evolution. Evolution is still very much a contentious subject even amongst scientists. It might be argued that that the real conflict in evolution dynamics occurs amongst higher organisms and that bacterial evolution is well understood, but we think not.

微生物学家正开始从以单细胞为中心的微生物观点转变为更多细胞的、以人口统计学为中心的观点，并意识到进化和适应与细胞的群落动态以及它们如何相互作用密切相关，很大程度上，多体物理学实际上揭示了新兴现象。该项目将进化生物学与纳米技术和物理学家的智慧方法结合在一起。这里使用的物理学家方法有两个方面：(1)利用物理技术开发的新技术，(2)对简单但重要的事情进行基本实验和分析：细菌进化。即使在科学家中间，进化论仍然是一个极具争议性的话题。有人可能会争辩说，进化动力学中的真正冲突发生在高等有机体之间，而且 细菌进化是众所周知的，但我们认为不是。