High Performance Detectors for SPECT

用于 SPECT 的高性能探测器

基本信息

项目摘要

DESCRIPTION (provided by applicant): High Performance Detectors for SPECT P.I.: Dr. Michael R. Squillante Abstract Single photon emission computed tomography (SPECT) is a powerful, noninvasive medical imaging modality that mathematically reconstructs the three dimensional distribution of a radionuclide throughout the body of a human patient or a research animal. Typically, the collected data are displayed and evaluated as a set of two-dimensional images through the organ or diseased area under investigation. SPECT allows quantitative study of the function in the investigated region and therefore is an extremely useful tool for understanding organ and tissue physiology including that in the heart. SPECT is very commonly used in identifying as well as localizing coronary artery disease and as many as 90% of all myocardial perfusion studies are now performed using SPECT. Thus, SPECT is playing a critical role in cardiac imaging, providing both diagnosis as well as prognosis. However, there is urgent need for improvement in the instrumentation that is currently used for this imaging modality and expand its capabilities in order to exploit its full potential. At present, the performance of SPECT systems often is limited by the detectors used in these systems. Modern SPECT systems consist of scintillation crystals coupled to photomultiplier tubes as detectors. Important requirements for scintillators used in SPECT applications include high light output and high energy resolution, reasonably fast response and high gamma ray stopping efficiency. Ideally, the scintillator should also be inexpensive, rugged and easy to manufacture. Currently, NaI(Tl) is the detector of choice in SPECT systems and it is relatively inexpensive and its light output is fairly large. However, the poor energy resolution of NaI(Tl) often limits SPECT performance. The energy resolution of NaI:Tl is limited by its relatively poor proportionality. If scintillators with higher energy resolution at typical SPECT energies (~140 keV) were available, the essential process of scatter rejection would improve. The goal of the proposed effort is to investigate new high resolution detectors for SPECT studies. Enhanced scatter rejection can be expected from the new detectors, which are also expected to be relatively easy to produce. The Phase I project will be aimed at demonstrating the feasibility of the proposed concept, while the Phase II project will be aimed at optimization of the new detectors, implementation of the prototype modules and detailed performance evaluation. PUBLIC HEALTH RELEVANCE: High Performance Detectors for SPECT P.I.: Dr. Michael R. Squillante Project Narrative - The proposed research will investigate a promising detector technology which should have a major impact in health care, in particular, in the development of detectors for in-vivo imaging. Other areas to which this research could be of benefit are: physics research, materials studies, homeland defense, and non-destructive testing.
描述(由申请人提供):用于 SPECT P.I. 的高性能探测器:Michael R. Squillante 博士 摘要 单光子发射计算机断层扫描 (SPECT) 是一种功能强大的非侵入性医学成像模式,可通过数学方式重建人类患者或研究动物体内放射性核素的三维分布。通常,收集的数据作为一组穿过所调查的器官或患病区域的二维图像进行显示和评估。 SPECT 可以对研究区域的功能进行定量研究,因此是了解器官和组织生理学(包括心脏)的极其有用的工具。 SPECT 非常常用于识别和定位冠状动脉疾病,现在多达 90% 的心肌灌注研究都是使用 SPECT 进行的。因此,SPECT 在心脏成像中发挥着关键作用,提供诊断和预后。然而,迫切需要改进目前用于这种成像模式的仪器并扩展其功能,以充分发挥其潜力。目前,SPECT 系统的性能常常受到这些系统中使用的探测器的限制。现代 SPECT 系统由与光电倍增管耦合的闪烁晶体组成,作为探测器。 SPECT 应用中使用的闪烁体的重要要求包括高光输出和高能量分辨率、相当快的响应和高伽马射线停止效率。理想情况下,闪烁体还应该便宜、坚固且易于制造。目前,NaI(Tl) 是 SPECT 系统中首选的探测器,它相对便宜且光输出相当大。然而,NaI(Tl) 较差的能量分辨率常常限制 SPECT 性能。 NaI:Tl 的能量分辨率因其相对较差的比例性而受到限制。如果可以使用在典型 SPECT 能量(约 140 keV)下具有更高能量分辨率的闪烁体,那么散射抑制的基本过程将会得到改善。拟议工作的目标是研究用于 SPECT 研究的新型高分辨率探测器。新探测器的散射抑制能力有望增强,而且预计也相对容易生产。第一阶段项目将旨在证明所提出概念的可行性,而第二阶段项目将旨在优化新探测器、实施原型模块和详细的性能评估。公共健康相关性:SPECT P.I. 的高性能探测器:Michael R. Squillante 博士项目叙述 - 拟议的研究将研究一种有前景的探测器技术,该技术将对医疗保健产生重大影响,特别是体内成像探测器的开发。这项研究可能有益的其他领域包括:物理研究、材料研究、国土防御和无损检测。

项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ monograph.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ sciAawards.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ conferencePapers.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ patent.updateTime }}

MICHAEL R. SQUILLANTE其他文献

MICHAEL R. SQUILLANTE的其他文献

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

{{ truncateString('MICHAEL R. SQUILLANTE', 18)}}的其他基金

Innovative High Resolution Dental X-ray Imager
创新的高分辨率牙科 X 射线成像仪
  • 批准号:
    10020966
  • 财政年份:
    2016
  • 资助金额:
    $ 60.81万
  • 项目类别:
High Performance Detectors for SPECT
用于 SPECT 的高性能探测器
  • 批准号:
    7745915
  • 财政年份:
    2009
  • 资助金额:
    $ 60.81万
  • 项目类别:
High Performance Detectors for SPECT
用于 SPECT 的高性能探测器
  • 批准号:
    8072309
  • 财政年份:
    2009
  • 资助金额:
    $ 60.81万
  • 项目类别:
Novel Detector for Molecular Imaging Studies
用于分子成像研究的新型探测器
  • 批准号:
    7502542
  • 财政年份:
    2008
  • 资助金额:
    $ 60.81万
  • 项目类别:
Instrument to Identify Hazardous Children's Products that Could Cause Lead Poison
识别可能导致铅中毒的危险儿童产品的仪器
  • 批准号:
    8056879
  • 财政年份:
    2007
  • 资助金额:
    $ 60.81万
  • 项目类别:
Instrument to Identify Hazardous Children's Products that Could Cause Lead Poison
识别可能导致铅中毒的危险儿童产品的仪器
  • 批准号:
    7404705
  • 财政年份:
    2007
  • 资助金额:
    $ 60.81万
  • 项目类别:
Instrument to Identify Hazardous Children's Products that Could Cause Lead Poison
识别可能导致铅中毒的危险儿童产品的仪器
  • 批准号:
    8212001
  • 财政年份:
    2007
  • 资助金额:
    $ 60.81万
  • 项目类别:
Low Cost Co-Doped Scintillator for Medical CT
用于医疗 CT 的低成本共掺杂闪烁体
  • 批准号:
    7481730
  • 财政年份:
    2006
  • 资助金额:
    $ 60.81万
  • 项目类别:
Low Cost Co Doped Scintillator for Medical CT
用于医疗 CT 的低成本掺钴闪烁体
  • 批准号:
    7108374
  • 财政年份:
    2006
  • 资助金额:
    $ 60.81万
  • 项目类别:
Low Cost Co-Doped Scintillator for Medical CT
用于医疗 CT 的低成本共掺杂闪烁体
  • 批准号:
    7691816
  • 财政年份:
    2006
  • 资助金额:
    $ 60.81万
  • 项目类别:

相似海外基金

Development of a Drosophila-based platform to replace and reduce animal experimentation in epilepsy research
开发基于果蝇的平台来取代和减少癫痫研究中的动物实验
  • 批准号:
    NC/V001051/1
  • 财政年份:
    2020
  • 资助金额:
    $ 60.81万
  • 项目类别:
    Research Grant
Doctoral Dissertation Research: Ethical Issues in Animal Experimentation
博士论文研究:动物实验的伦理问题
  • 批准号:
    1424484
  • 财政年份:
    2014
  • 资助金额:
    $ 60.81万
  • 项目类别:
    Standard Grant
Animal Experimentation Core
动物实验核心
  • 批准号:
    7665015
  • 财政年份:
    2008
  • 资助金额:
    $ 60.81万
  • 项目类别:
Core--Animal Experimentation
核心——动物实验
  • 批准号:
    7422298
  • 财政年份:
    2007
  • 资助金额:
    $ 60.81万
  • 项目类别:
Animal Experimentation Core
动物实验核心
  • 批准号:
    7502321
  • 财政年份:
    2007
  • 资助金额:
    $ 60.81万
  • 项目类别:
Tissue formation involving stem/progenitor cell research and animal experimentation (N01)
涉及干/祖细胞研究和动物实验的组织形成(N01)
  • 批准号:
    30245585
  • 财政年份:
    2006
  • 资助金额:
    $ 60.81万
  • 项目类别:
    Collaborative Research Centres
Core--Animal Experimentation
核心——动物实验
  • 批准号:
    7312565
  • 财政年份:
    2006
  • 资助金额:
    $ 60.81万
  • 项目类别:
Animal experimentation and cardiac phenotyping of transgenic mouse models
转基因小鼠模型的动物实验和心脏表型分析
  • 批准号:
    13327687
  • 财政年份:
    2005
  • 资助金额:
    $ 60.81万
  • 项目类别:
    Research Units
Animal Experimentation system as an infrastructure to support translational progression of diabetes research to medical practice
动物实验系统作为支持糖尿病研究向医学实践转化的基础设施
  • 批准号:
    17200029
  • 财政年份:
    2005
  • 资助金额:
    $ 60.81万
  • 项目类别:
    Grant-in-Aid for Scientific Research (A)
Core--Animal Experimentation
核心——动物实验
  • 批准号:
    6892955
  • 财政年份:
    2005
  • 资助金额:
    $ 60.81万
  • 项目类别:
{{ showInfoDetail.title }}

作者:{{ showInfoDetail.author }}

知道了