Training Program in Translational Radiation Oncology

描述（由申请人提供）：放射肿瘤学、生物学和物理学站在新治疗方法的门槛上，这些新治疗方法有望利用放射传递、分子生物学和分子成像方面的非凡进展，这些进展将显著影响癌症患者的长期生存和生活质量（QOL）。然而，为了确保这些进步的成功发展，必须建立一支由基础科学家、医学物理学家和放射肿瘤学家组成的骨干队伍，他们拥有共同的知识基础，致力于将这些知识转化为临床实践。为了满足这些需求，WFUHS放射肿瘤学部门的博士后转化放射肿瘤学培训计划（TRADONC）于2005年成立，并获得nci资助。该计划的主要目标是：i]通过增加具有生物学或物理学背景的训练有素的基础科学家的数量，拓宽转化辐射研究人员的研究基础；ii]培养一支精通假设驱动的基础、转化和临床研究的放射肿瘤学家骨干队伍；iii]为生物学家、物理学家、放射肿瘤学家拥有共同的知识基础，这将使他们能够有效地相互作用，以改善癌症患者对放射治疗的反应和他们的生活质量。

DESCRIPTION (provided by applicant): Radiation oncology, biology and physics stand at the threshold of new approaches to treatment that promise to utilize the extraordinary advances in radiation delivery, molecular biology, and molecular imaging that will significantly affect a cancer patient's long-term survival and quality of life (QOL). However, ensuring the successful development of these advances necessitates the creation of a cadre of basic scientists, medical physicists and radiation oncologists with a common base of knowledge, dedicated to translating this knowledge into clinical practice To help meet these needs, the Postdoctoral Training Program in Translational Radiation Oncology (TRADONC) in the Department of Radiation Oncology at WFUHS was established and awarded NCI-funding in 2005. The major goals of this program are to i] broaden the research infrastructure of translational radiation researchers by increasing the number of well-trained basic scientists with biology or physics backgrounds exposed to clinical radiation oncology, ii] develop a cadre of radiation oncologists proficient in hypothesis-driven basic, translational, and clinical research, and iii] equip biologists, physicists, and radiation oncologists with a common knowledge base that will allow them to interact effectively to improve the response of cancer patients to radiotherapy and their quality of life. We believe that have made excellent progress during the initial 5 years of funding. We have had >100 individuals apply to the program and have appointed 5 basic scientists, 3 medical physicists, and 2 radiation oncologists. Four trainees have completed or left the program; 6 are still in training. In this renewal, we request continued support for 6 trainee positions per year. Although the overall goals of TRADONC have not changed, we have made several modifications to the training program based on our experience and the recommendations of the lAB and EAB. These include, i] changing the 3-year fellowship to 2 years with an optional 3'^'' year, to help attract and meet the needs of the MD trainees, ii] requiring a rotation through all the radiation oncology services for the PhDs, and iii] supplementing the year of clinical research with a Challenges in Radiation Oncology Forum. With these changes, we believe that the program will be even more successful in generating the cadre of translational basic scientists, medical physicists and radiation oncologist required to meet the radiation oncology challenges of the 21st century. RELEVANCE: Training radiation oncologists, biologists, and physicists to interact and communicate effectively in multi disciplinary research teams will ensure the effective translation of advances in radiation delivery, treatment planning, imaging and biology, to the cancer patient, resulting in significant improvements in long-term survival and quality of life.