Biometric Genetic Analysis of Cardiopulmonary Disease

描述（由申请人提供：该计划将提供博士前和博士后培训，以培养未来的独立研究人员，这些研究人员具有跨NHLBI几个基本使命领域的多学科经验（睡眠和缺氧反应，心肺和心肾疾病，高血压和炎症/感染），但植根于严格的生物统计学，流行病学，遗传/基因组和计算方法来解决问题。仅提供 博士后培训的第一个十五年，该计划于1999年扩大，以提供两个 博士前和博士后培训，并将继续提供这两种类型的培训。博士前培训将是为博士。通过遗传和分子流行病学系，获得流行病学和生物统计学学位，学员获得人口科学方面的一般专门知识，特别是通过开发创新建模策略解决与大样本“组学”有关的问题。这将在指导委员会的帮助下完成，该委员会将确保学生接受统计遗传学方面的良好培训，并与其他部门和卓越中心的更广泛案例社区合作， 临床和基础科学专业知识。博士后最重要的培养模式是 与教师进行合作研究：方法研究（使用数学 推导或计算机模拟）和/或通过数据分析进行实质性研究。是 预计有一半的博士后学生已经接受了心肺领域的培训，但为了获得必要的流行病学/统计学专业知识，将需要正式注册流行病学和生物统计学硕士学位。所有受训人员，包括博士前和博士后，将参加定期安排的研讨会和具体讲座和/或阅读课程，包括生物伦理学的必修课。该方案的特点将是：计算实验室交叉培训、基础科学实验室短期培训、与医学科学家培训方案的互动，以及国际知名的生物统计学家/遗传学家/遗传流行病学家作为访问者，为期一天至几天，在他们的专业领域举办研讨会和短期课程，并与学员谈论他们的研究项目。

DESCRIPTION (provided by applicant: This program will provide predoctoral and postdoctoral training to produce future independent investigators with multidisciplinary experiences that span several basic mission areas of the NHLBI (sleep and hypoxic response, cardiopulmonary and cardio-renal diseases, hypertension, and inflammation/infection), but is rooted in rigorous biostatistical, epidemiologic, genetic/genomic and computational approaches to problem solving. After providing only postdoctoral training for the first fifteen years, the program was expanded in 1999 to provide both predoctoral and postdoctoral training and will continue to provide both types of training. Predoctoral training will be for the Ph.D. degree in Epidemiology and Biostatistics through the Division of Genetic and Molecular Epidemiology, with the trainees gaining general expertise in population sciences, particularly in solving problems related to "omics" in large samples through the development of innovative modeling strategies. This will be done with the help of a mentoring committee that will ensure the student receives sound training in statistical genetics as well as exposure to collaborations with the broader Case Community in other departments and Centers of Excellence that have relevant clinical and basic science expertise. The most important mode of training for postdoctoral students will be that of conducting collaborative research with faculty: methodological research (using mathematical derivations or computer simulations) and/or substantive research by means of data analysis. It is anticipated that half the postdoctoral students will already have had training in a cardiopulmonary area but, in order to gain the necessary epidemiological/statistical expertise, will need to formally register for the MS degree in Epidemiology and Biostatistics. All trainees, both pre- and post-doctoral, will attend regularly scheduled seminars and specific lecture and/or reading courses, including mandatory lectures in bioethics. Particular features of the program will be; computational laboratory cross-training, short-term training stints in basic science laboratories, interaction with the Medical Scientist Training Program, and the presence of internationally known biostatisticians/geneticists/genetic epidemiologists as visitors, for periods of one to several days, giving seminars and short courses in their particular fields of specialty and talking to the trainees about their research projects.